Effects of Intracoronary Gallopamil on Coronary Hemodynamics and Myocardial Oxygen Consumption in Humans
The response of coronary hemodynamics to the intracoronary (i.c.) bolus administration of gallopamil, 1.5 and 3.0 μg/kg, was evaluated in 14 patients with normal coronary arteries. Gallopamil, 3.0 μg/kg, induced a small and transient decrease in systolic and mean arterial pressure and a small increa...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1991-05, Vol.17 (5), p.822-829 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Vigorito, Carlo Giordano, Arturo Caprio, Lorenzo De Vitale, Dino F Ferraro, Paolo Libutti, Nicola Vastano, Luisa Naddeo, Corrado Rengo, Franco |
| description | The response of coronary hemodynamics to the intracoronary (i.c.) bolus administration of gallopamil, 1.5 and 3.0 μg/kg, was evaluated in 14 patients with normal coronary arteries. Gallopamil, 3.0 μg/kg, induced a small and transient decrease in systolic and mean arterial pressure and a small increase in the preejection period. Coronary sinus blood flow increased significantly at 30 s (p < 0.01) and returned to baseline 10 min after gallopamil administration. Coronary vascular resistance was still reduced at 10 min and returned to baseline at 15 min. Myocardial O2 consumption and extraction decreased significantly (p < 0.01) at 30 s. While myocardial O2 consumption returned to baseline 15 min after gallopamil administration, myocardial O2 extraction was still significantly reduced at this time. Milder and more transient changes were observed after i.c. administration of the lower dose (1.5 μg/kg), and no significant changes were found after i.c. administration of saline. These data show that i.e. gallopamil, in patients with normal coronary arteries, induces direct, transient, and dose-related peripheral coronary vasodilation. The reduction of myocardial O2 consumption and extraction suggests a direct negative inotropic and metabolic effect of gallopamil. |
| doi_str_mv | 10.1097/00005344-199105000-00019 |
| format | Article |
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Gallopamil, 3.0 μg/kg, induced a small and transient decrease in systolic and mean arterial pressure and a small increase in the preejection period. Coronary sinus blood flow increased significantly at 30 s (p < 0.01) and returned to baseline 10 min after gallopamil administration. Coronary vascular resistance was still reduced at 10 min and returned to baseline at 15 min. Myocardial O2 consumption and extraction decreased significantly (p < 0.01) at 30 s. While myocardial O2 consumption returned to baseline 15 min after gallopamil administration, myocardial O2 extraction was still significantly reduced at this time. Milder and more transient changes were observed after i.c. administration of the lower dose (1.5 μg/kg), and no significant changes were found after i.c. administration of saline. These data show that i.e. gallopamil, in patients with normal coronary arteries, induces direct, transient, and dose-related peripheral coronary vasodilation. The reduction of myocardial O2 consumption and extraction suggests a direct negative inotropic and metabolic effect of gallopamil.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-199105000-00019</identifier><identifier>PMID: 1713999</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Adult ; Aged ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Coronary Circulation - drug effects ; Dose-Response Relationship, Drug ; Female ; Gallopamil - administration & dosage ; Gallopamil - pharmacology ; Heart - drug effects ; Hemodynamics - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardium - metabolism ; Oxygen Consumption - drug effects ; Pharmacology. Drug treatments</subject><ispartof>Journal of cardiovascular pharmacology, 1991-05, Vol.17 (5), p.822-829</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4359-844ac948176cd922e8b57c76e75985ea27b825e724c66b649b539d4aecf434c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00005344-199105000-00019$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-199105000-00019$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19781530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1713999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vigorito, Carlo</creatorcontrib><creatorcontrib>Giordano, Arturo</creatorcontrib><creatorcontrib>Caprio, Lorenzo De</creatorcontrib><creatorcontrib>Vitale, Dino F</creatorcontrib><creatorcontrib>Ferraro, Paolo</creatorcontrib><creatorcontrib>Libutti, Nicola</creatorcontrib><creatorcontrib>Vastano, Luisa</creatorcontrib><creatorcontrib>Naddeo, Corrado</creatorcontrib><creatorcontrib>Rengo, Franco</creatorcontrib><title>Effects of Intracoronary Gallopamil on Coronary Hemodynamics and Myocardial Oxygen Consumption in Humans</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>The response of coronary hemodynamics to the intracoronary (i.c.) bolus administration of gallopamil, 1.5 and 3.0 μg/kg, was evaluated in 14 patients with normal coronary arteries. Gallopamil, 3.0 μg/kg, induced a small and transient decrease in systolic and mean arterial pressure and a small increase in the preejection period. Coronary sinus blood flow increased significantly at 30 s (p < 0.01) and returned to baseline 10 min after gallopamil administration. Coronary vascular resistance was still reduced at 10 min and returned to baseline at 15 min. Myocardial O2 consumption and extraction decreased significantly (p < 0.01) at 30 s. While myocardial O2 consumption returned to baseline 15 min after gallopamil administration, myocardial O2 extraction was still significantly reduced at this time. Milder and more transient changes were observed after i.c. administration of the lower dose (1.5 μg/kg), and no significant changes were found after i.c. administration of saline. These data show that i.e. gallopamil, in patients with normal coronary arteries, induces direct, transient, and dose-related peripheral coronary vasodilation. The reduction of myocardial O2 consumption and extraction suggests a direct negative inotropic and metabolic effect of gallopamil.</description><subject>Adult</subject><subject>Aged</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Coronary Circulation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Gallopamil - administration & dosage</subject><subject>Gallopamil - pharmacology</subject><subject>Heart - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardium - metabolism</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pharmacology. Drug treatments</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v3CAQhlHUKtmm_QmVuCQ3t2CGr2O1SrKRUuXSnhHGOOsGwxZsJfvvS7qb5lSkEWLmeQfNOwhhSr5QouVXUg9nAA3VmhJeX00Nqk_QinLGGiAte4dWhArStADiDH0o5VclgEtxik6ppExrvULbq2Hwbi44Dfg2ztm6lFO0eY9vbAhpZ6cx4BTx-jW98VPq97HmXcE29vj7Pjmb-9EGfP-8f_AvbCzLtJvHqhsj3iyTjeUjej_YUPyn432Ofl5f_Vhvmrv7m9v1t7vGAeO6UQDWaVBUCtfrtvWq49JJ4SXXinvbyk613MsWnBCdAN1xpnuw3g3AwCl2ji4PfXc5_V58mc00FudDsNGnpRhFZCsUiAqqA-hyKiX7wezyONURDSXmxWTzarL5Z7L5a3KVfj7-sXST79-EB1dr_eJYt8XZMGQb3VjeMC1V3RKpHBy4pxRmn8tjWJ58Nltvw7w1_9sx-wMyhpRy</recordid><startdate>199105</startdate><enddate>199105</enddate><creator>Vigorito, Carlo</creator><creator>Giordano, Arturo</creator><creator>Caprio, Lorenzo De</creator><creator>Vitale, Dino F</creator><creator>Ferraro, Paolo</creator><creator>Libutti, Nicola</creator><creator>Vastano, Luisa</creator><creator>Naddeo, Corrado</creator><creator>Rengo, Franco</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199105</creationdate><title>Effects of Intracoronary Gallopamil on Coronary Hemodynamics and Myocardial Oxygen Consumption in Humans</title><author>Vigorito, Carlo ; Giordano, Arturo ; Caprio, Lorenzo De ; Vitale, Dino F ; Ferraro, Paolo ; Libutti, Nicola ; Vastano, Luisa ; Naddeo, Corrado ; Rengo, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4359-844ac948176cd922e8b57c76e75985ea27b825e724c66b649b539d4aecf434c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Coronary Circulation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Gallopamil - administration & dosage</topic><topic>Gallopamil - pharmacology</topic><topic>Heart - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardium - metabolism</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vigorito, Carlo</creatorcontrib><creatorcontrib>Giordano, Arturo</creatorcontrib><creatorcontrib>Caprio, Lorenzo De</creatorcontrib><creatorcontrib>Vitale, Dino F</creatorcontrib><creatorcontrib>Ferraro, Paolo</creatorcontrib><creatorcontrib>Libutti, Nicola</creatorcontrib><creatorcontrib>Vastano, Luisa</creatorcontrib><creatorcontrib>Naddeo, Corrado</creatorcontrib><creatorcontrib>Rengo, Franco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vigorito, Carlo</au><au>Giordano, Arturo</au><au>Caprio, Lorenzo De</au><au>Vitale, Dino F</au><au>Ferraro, Paolo</au><au>Libutti, Nicola</au><au>Vastano, Luisa</au><au>Naddeo, Corrado</au><au>Rengo, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Intracoronary Gallopamil on Coronary Hemodynamics and Myocardial Oxygen Consumption in Humans</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1991-05</date><risdate>1991</risdate><volume>17</volume><issue>5</issue><spage>822</spage><epage>829</epage><pages>822-829</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>The response of coronary hemodynamics to the intracoronary (i.c.) bolus administration of gallopamil, 1.5 and 3.0 μg/kg, was evaluated in 14 patients with normal coronary arteries. Gallopamil, 3.0 μg/kg, induced a small and transient decrease in systolic and mean arterial pressure and a small increase in the preejection period. Coronary sinus blood flow increased significantly at 30 s (p < 0.01) and returned to baseline 10 min after gallopamil administration. Coronary vascular resistance was still reduced at 10 min and returned to baseline at 15 min. Myocardial O2 consumption and extraction decreased significantly (p < 0.01) at 30 s. While myocardial O2 consumption returned to baseline 15 min after gallopamil administration, myocardial O2 extraction was still significantly reduced at this time. Milder and more transient changes were observed after i.c. administration of the lower dose (1.5 μg/kg), and no significant changes were found after i.c. administration of saline. These data show that i.e. gallopamil, in patients with normal coronary arteries, induces direct, transient, and dose-related peripheral coronary vasodilation. The reduction of myocardial O2 consumption and extraction suggests a direct negative inotropic and metabolic effect of gallopamil.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1713999</pmid><doi>10.1097/00005344-199105000-00019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Coronary Circulation - drug effects Dose-Response Relationship, Drug Female Gallopamil - administration & dosage Gallopamil - pharmacology Heart - drug effects Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Myocardium - metabolism Oxygen Consumption - drug effects Pharmacology. Drug treatments |
| title | Effects of Intracoronary Gallopamil on Coronary Hemodynamics and Myocardial Oxygen Consumption in Humans |
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