Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate

Once-a-month injectable microspheres of leuprolide acetate prepared with copoly(DL-lactic/glycolic acid) using an in-water drying method were assessed for duration of the analogue release and pharmacological effects in rats after a single or repeated injection. The periodic challenge test revealed t...

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Veröffentlicht in:	Pharmaceutical research 1991-05, Vol.8 (5), p.584-587
Hauptverfasser:	OKADA, H, HEYA, T, OGAWA, Y, TOGUCHI, H, SHIMAMOTO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Delayed-Action Preparations Follicle Stimulating Hormone - blood General pharmacology Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacokinetics Gonadotropin-Releasing Hormone - pharmacology Hormones - administration & dosage Hormones - pharmacokinetics Hormones - pharmacology Injections, Subcutaneous Leuprolide Luteinizing Hormone - blood Male Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Inbred Strains Testosterone - blood Time Factors
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