Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Rac is a member of the Ras superfamily of GTPases and functions as a GDP/GTP-regulated switch 1 . Formation of active Rac-GTP is stimulated by Dbl family guanine nucleotide exchange factors (GEFs), such as Tiam1 (ref. 2 ). Once activated, Rac stimulates signalling pathways that regulate actin organi...

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Veröffentlicht in:	Nature cell biology 2002-08, Vol.4 (8), p.621-625
Hauptverfasser:	Lambert, John M., Lambert, Que T., Reuther, Gary W., Malliri, Angeliki, Siderovski, David P., Sondek, John, Collard, John G., Der, Channing J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding Sites Biomedical and Life Sciences brief-communication Cancer Research Cell Biology Cell Line Developmental Biology Guanine Nucleotide Exchange Factors Humans Kinases Life Sciences Mice Phosphatidylinositol 3-Kinases - metabolism Protein Structure, Tertiary Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism rac GTP-Binding Proteins - metabolism ras Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Stem Cells T-Lymphoma Invasion and Metastasis-inducing Protein 1
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