Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii
Summary Objectives The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii. Methods All cases of HAP caused by A. baumannii from January 2000 to March 2006 at the S...
Gespeichert in:
| Veröffentlicht in: | The Journal of infection 2010-09, Vol.61 (3), p.212-218 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 218 |
|---|---|
| container_issue | 3 |
| container_start_page | 212 |
| container_title | The Journal of infection |
| container_volume | 61 |
| creator | Joung, Mi Kyong Kwon, Ki Tae Kang, Cheol-In Cheong, Hae Suk Rhee, Ji-young Jung, Dong Sik Chung, Seung Min Lee, Jeong A Moon, Soo-youn Ko, Kwan Soo Chung, Doo Ryeon Lee, Nam Yong Song, Jae-Hoon Peck, Kyong Ran |
| description | Summary Objectives The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii. Methods All cases of HAP caused by A. baumannii from January 2000 to March 2006 at the Samsung Medical Center (Seoul, Korea) were analyzed retrospectively. Results A total of 116 patients with clinically significant Acinetobacter HAP were enrolled. Among the A. baumannii isolates, 60.3% showed multi-drug resistance (MDR), 16.4% were found to have imipenem resistance, and 15.5% had pan-drug resistance (PDR). The mean APACHE II score of the patients was 22.3 ± 7.9. The overall in-hospital and pneumonia-related mortality rates were 47.4% and 37.9%, respectively. The univariate analysis showed that the factors associated with pneumonia-related mortality were: MDR, PDR, high APACHE II score, inappropriate empirical antimicrobial therapy, and inappropriate definitive antimicrobial treatment (All p |
| doi_str_mv | 10.1016/j.jinf.2010.06.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_807265491</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0163445310001817</els_id><sourcerecordid>807265491</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-ae9be988fdb2e68a88d2756326e39e8105dced1a06639eb22e104254bd90dd2d3</originalsourceid><addsrcrecordid>eNqFkk-L1TAQwIso7nP1C3iQXMRTn0napimIsCz-WVjwoJ7DNJnyUtukm6Qr7xP4tU15TwUPegoZfjOTzG-K4jmje0aZeD3uR-uGPac5QMWesvpBsWNNxUve1vxhsctQVdZ1U10UT2IcKaVd1YnHxQWnglLeNbvix828gE7ED8Q6WJbgl2AhIQGX7Gx18L2FiaQDBliOxDvi16T9jBknCySLLkXy3aYDOfi42ARTCfputQENWRyus3cWiIY15kB_JFfaOky-z00xkB7WGZyz9mnxaIAp4rPzeVl8ff_uy_XH8vbTh5vrq9tS1y1PJWDXYyflYHqOQoKUhreNqLjAqkPJaGM0GgZUiHzvOUdGa97UvemoMdxUl8WrU93807sVY1KzjRqnCRz6NSpJWy6aumP_JdtadrIVjcwkP5F5WjEGHFSe4QzhqBhVmyk1qs2U2kwpKlQ2lZNenMuv_Yzmd8ovNRl4eQYgapiGAE7b-IerOOON2Aq9OXGYx3ZvMaios5U8huxAJ2W8_fc73v6VrifrbO74DY8YR78Gl4UopiJXVH3edmpbKZa3iUnWVj8BUuPJVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>748987658</pqid></control><display><type>article</type><title>Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Joung, Mi Kyong ; Kwon, Ki Tae ; Kang, Cheol-In ; Cheong, Hae Suk ; Rhee, Ji-young ; Jung, Dong Sik ; Chung, Seung Min ; Lee, Jeong A ; Moon, Soo-youn ; Ko, Kwan Soo ; Chung, Doo Ryeon ; Lee, Nam Yong ; Song, Jae-Hoon ; Peck, Kyong Ran</creator><creatorcontrib>Joung, Mi Kyong ; Kwon, Ki Tae ; Kang, Cheol-In ; Cheong, Hae Suk ; Rhee, Ji-young ; Jung, Dong Sik ; Chung, Seung Min ; Lee, Jeong A ; Moon, Soo-youn ; Ko, Kwan Soo ; Chung, Doo Ryeon ; Lee, Nam Yong ; Song, Jae-Hoon ; Peck, Kyong Ran</creatorcontrib><description>Summary Objectives The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii. Methods All cases of HAP caused by A. baumannii from January 2000 to March 2006 at the Samsung Medical Center (Seoul, Korea) were analyzed retrospectively. Results A total of 116 patients with clinically significant Acinetobacter HAP were enrolled. Among the A. baumannii isolates, 60.3% showed multi-drug resistance (MDR), 16.4% were found to have imipenem resistance, and 15.5% had pan-drug resistance (PDR). The mean APACHE II score of the patients was 22.3 ± 7.9. The overall in-hospital and pneumonia-related mortality rates were 47.4% and 37.9%, respectively. The univariate analysis showed that the factors associated with pneumonia-related mortality were: MDR, PDR, high APACHE II score, inappropriate empirical antimicrobial therapy, and inappropriate definitive antimicrobial treatment (All p < 0.05). Among these, a high APACHE II score and inappropriate definitive antimicrobial therapy were found to be independent factors associated with a high mortality, after adjustment for other variables. Conclusions The appropriate definitive antimicrobial therapy should be provided in patients with HAP caused by A. baumannii.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2010.06.014</identifier><identifier>PMID: 20600295</identifier><identifier>CODEN: JINFD2</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Acinetobacter ; Acinetobacter baumannii ; Acinetobacter baumannii - isolation & purification ; Acinetobacter Infections - drug therapy ; Acinetobacter Infections - microbiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; APACHE ; Biological and medical sciences ; Cross Infection - drug therapy ; Cross Infection - microbiology ; Definitive antimicrobial therapy ; Drug Resistance, Multiple, Bacterial ; Female ; General aspects ; Hospital-acquired pneumonia ; Human infectious diseases. Experimental studies and models ; Humans ; Inappropriate ; Inappropriate Prescribing ; Infectious Disease ; Infectious diseases ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pneumonia, Bacterial - drug therapy ; Pneumonia, Bacterial - microbiology ; Respiratory system : syndromes and miscellaneous diseases ; Retrospective Studies ; Risk Factors ; Treatment Outcome</subject><ispartof>The Journal of infection, 2010-09, Vol.61 (3), p.212-218</ispartof><rights>The British Infection Society</rights><rights>2010 The British Infection Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-ae9be988fdb2e68a88d2756326e39e8105dced1a06639eb22e104254bd90dd2d3</citedby><cites>FETCH-LOGICAL-c472t-ae9be988fdb2e68a88d2756326e39e8105dced1a06639eb22e104254bd90dd2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinf.2010.06.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23212564$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20600295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joung, Mi Kyong</creatorcontrib><creatorcontrib>Kwon, Ki Tae</creatorcontrib><creatorcontrib>Kang, Cheol-In</creatorcontrib><creatorcontrib>Cheong, Hae Suk</creatorcontrib><creatorcontrib>Rhee, Ji-young</creatorcontrib><creatorcontrib>Jung, Dong Sik</creatorcontrib><creatorcontrib>Chung, Seung Min</creatorcontrib><creatorcontrib>Lee, Jeong A</creatorcontrib><creatorcontrib>Moon, Soo-youn</creatorcontrib><creatorcontrib>Ko, Kwan Soo</creatorcontrib><creatorcontrib>Chung, Doo Ryeon</creatorcontrib><creatorcontrib>Lee, Nam Yong</creatorcontrib><creatorcontrib>Song, Jae-Hoon</creatorcontrib><creatorcontrib>Peck, Kyong Ran</creatorcontrib><title>Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>Summary Objectives The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii. Methods All cases of HAP caused by A. baumannii from January 2000 to March 2006 at the Samsung Medical Center (Seoul, Korea) were analyzed retrospectively. Results A total of 116 patients with clinically significant Acinetobacter HAP were enrolled. Among the A. baumannii isolates, 60.3% showed multi-drug resistance (MDR), 16.4% were found to have imipenem resistance, and 15.5% had pan-drug resistance (PDR). The mean APACHE II score of the patients was 22.3 ± 7.9. The overall in-hospital and pneumonia-related mortality rates were 47.4% and 37.9%, respectively. The univariate analysis showed that the factors associated with pneumonia-related mortality were: MDR, PDR, high APACHE II score, inappropriate empirical antimicrobial therapy, and inappropriate definitive antimicrobial treatment (All p < 0.05). Among these, a high APACHE II score and inappropriate definitive antimicrobial therapy were found to be independent factors associated with a high mortality, after adjustment for other variables. Conclusions The appropriate definitive antimicrobial therapy should be provided in patients with HAP caused by A. baumannii.</description><subject>Acinetobacter</subject><subject>Acinetobacter baumannii</subject><subject>Acinetobacter baumannii - isolation & purification</subject><subject>Acinetobacter Infections - drug therapy</subject><subject>Acinetobacter Infections - microbiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>APACHE</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - drug therapy</subject><subject>Cross Infection - microbiology</subject><subject>Definitive antimicrobial therapy</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospital-acquired pneumonia</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Inappropriate</subject><subject>Inappropriate Prescribing</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pneumonia, Bacterial - drug therapy</subject><subject>Pneumonia, Bacterial - microbiology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-L1TAQwIso7nP1C3iQXMRTn0napimIsCz-WVjwoJ7DNJnyUtukm6Qr7xP4tU15TwUPegoZfjOTzG-K4jmje0aZeD3uR-uGPac5QMWesvpBsWNNxUve1vxhsctQVdZ1U10UT2IcKaVd1YnHxQWnglLeNbvix828gE7ED8Q6WJbgl2AhIQGX7Gx18L2FiaQDBliOxDvi16T9jBknCySLLkXy3aYDOfi42ARTCfputQENWRyus3cWiIY15kB_JFfaOky-z00xkB7WGZyz9mnxaIAp4rPzeVl8ff_uy_XH8vbTh5vrq9tS1y1PJWDXYyflYHqOQoKUhreNqLjAqkPJaGM0GgZUiHzvOUdGa97UvemoMdxUl8WrU93807sVY1KzjRqnCRz6NSpJWy6aumP_JdtadrIVjcwkP5F5WjEGHFSe4QzhqBhVmyk1qs2U2kwpKlQ2lZNenMuv_Yzmd8ovNRl4eQYgapiGAE7b-IerOOON2Aq9OXGYx3ZvMaios5U8huxAJ2W8_fc73v6VrifrbO74DY8YR78Gl4UopiJXVH3edmpbKZa3iUnWVj8BUuPJVQ</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Joung, Mi Kyong</creator><creator>Kwon, Ki Tae</creator><creator>Kang, Cheol-In</creator><creator>Cheong, Hae Suk</creator><creator>Rhee, Ji-young</creator><creator>Jung, Dong Sik</creator><creator>Chung, Seung Min</creator><creator>Lee, Jeong A</creator><creator>Moon, Soo-youn</creator><creator>Ko, Kwan Soo</creator><creator>Chung, Doo Ryeon</creator><creator>Lee, Nam Yong</creator><creator>Song, Jae-Hoon</creator><creator>Peck, Kyong Ran</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100901</creationdate><title>Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii</title><author>Joung, Mi Kyong ; Kwon, Ki Tae ; Kang, Cheol-In ; Cheong, Hae Suk ; Rhee, Ji-young ; Jung, Dong Sik ; Chung, Seung Min ; Lee, Jeong A ; Moon, Soo-youn ; Ko, Kwan Soo ; Chung, Doo Ryeon ; Lee, Nam Yong ; Song, Jae-Hoon ; Peck, Kyong Ran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-ae9be988fdb2e68a88d2756326e39e8105dced1a06639eb22e104254bd90dd2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acinetobacter</topic><topic>Acinetobacter baumannii</topic><topic>Acinetobacter baumannii - isolation & purification</topic><topic>Acinetobacter Infections - drug therapy</topic><topic>Acinetobacter Infections - microbiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>APACHE</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - drug therapy</topic><topic>Cross Infection - microbiology</topic><topic>Definitive antimicrobial therapy</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospital-acquired pneumonia</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Inappropriate</topic><topic>Inappropriate Prescribing</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pneumonia, Bacterial - drug therapy</topic><topic>Pneumonia, Bacterial - microbiology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joung, Mi Kyong</creatorcontrib><creatorcontrib>Kwon, Ki Tae</creatorcontrib><creatorcontrib>Kang, Cheol-In</creatorcontrib><creatorcontrib>Cheong, Hae Suk</creatorcontrib><creatorcontrib>Rhee, Ji-young</creatorcontrib><creatorcontrib>Jung, Dong Sik</creatorcontrib><creatorcontrib>Chung, Seung Min</creatorcontrib><creatorcontrib>Lee, Jeong A</creatorcontrib><creatorcontrib>Moon, Soo-youn</creatorcontrib><creatorcontrib>Ko, Kwan Soo</creatorcontrib><creatorcontrib>Chung, Doo Ryeon</creatorcontrib><creatorcontrib>Lee, Nam Yong</creatorcontrib><creatorcontrib>Song, Jae-Hoon</creatorcontrib><creatorcontrib>Peck, Kyong Ran</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joung, Mi Kyong</au><au>Kwon, Ki Tae</au><au>Kang, Cheol-In</au><au>Cheong, Hae Suk</au><au>Rhee, Ji-young</au><au>Jung, Dong Sik</au><au>Chung, Seung Min</au><au>Lee, Jeong A</au><au>Moon, Soo-youn</au><au>Ko, Kwan Soo</au><au>Chung, Doo Ryeon</au><au>Lee, Nam Yong</au><au>Song, Jae-Hoon</au><au>Peck, Kyong Ran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>61</volume><issue>3</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><coden>JINFD2</coden><abstract>Summary Objectives The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii. Methods All cases of HAP caused by A. baumannii from January 2000 to March 2006 at the Samsung Medical Center (Seoul, Korea) were analyzed retrospectively. Results A total of 116 patients with clinically significant Acinetobacter HAP were enrolled. Among the A. baumannii isolates, 60.3% showed multi-drug resistance (MDR), 16.4% were found to have imipenem resistance, and 15.5% had pan-drug resistance (PDR). The mean APACHE II score of the patients was 22.3 ± 7.9. The overall in-hospital and pneumonia-related mortality rates were 47.4% and 37.9%, respectively. The univariate analysis showed that the factors associated with pneumonia-related mortality were: MDR, PDR, high APACHE II score, inappropriate empirical antimicrobial therapy, and inappropriate definitive antimicrobial treatment (All p < 0.05). Among these, a high APACHE II score and inappropriate definitive antimicrobial therapy were found to be independent factors associated with a high mortality, after adjustment for other variables. Conclusions The appropriate definitive antimicrobial therapy should be provided in patients with HAP caused by A. baumannii.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>20600295</pmid><doi>10.1016/j.jinf.2010.06.014</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2010-09, Vol.61 (3), p.212-218 |
| issn | 0163-4453 1532-2742 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_807265491 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acinetobacter Acinetobacter baumannii Acinetobacter baumannii - isolation & purification Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology Adolescent Adult Aged Aged, 80 and over Analysis of Variance Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use APACHE Biological and medical sciences Cross Infection - drug therapy Cross Infection - microbiology Definitive antimicrobial therapy Drug Resistance, Multiple, Bacterial Female General aspects Hospital-acquired pneumonia Human infectious diseases. Experimental studies and models Humans Inappropriate Inappropriate Prescribing Infectious Disease Infectious diseases Kaplan-Meier Estimate Male Medical sciences Middle Aged Pneumology Pneumonia, Bacterial - drug therapy Pneumonia, Bacterial - microbiology Respiratory system : syndromes and miscellaneous diseases Retrospective Studies Risk Factors Treatment Outcome |
| title | Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T09%3A47%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20inappropriate%20antimicrobial%20therapy%20on%20outcome%20in%20patients%20with%20hospital-acquired%20pneumonia%20caused%20by%20Acinetobacter%20baumannii&rft.jtitle=The%20Journal%20of%20infection&rft.au=Joung,%20Mi%20Kyong&rft.date=2010-09-01&rft.volume=61&rft.issue=3&rft.spage=212&rft.epage=218&rft.pages=212-218&rft.issn=0163-4453&rft.eissn=1532-2742&rft.coden=JINFD2&rft_id=info:doi/10.1016/j.jinf.2010.06.014&rft_dat=%3Cproquest_cross%3E807265491%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=748987658&rft_id=info:pmid/20600295&rft_els_id=1_s2_0_S0163445310001817&rfr_iscdi=true |