Escape from premature senescence is not sufficient for oncogenic transformation by Ras

Resistance of primary cells to transformation by oncogenic Ras has been attributed to the induction of replicative growth arrest. This irreversible 'fail-safe mechanism' resembles senescence and requires induction by Ras of p19ARF and p53 (refs 3-5). Mutation of either p19ARF or p53 allevi...

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Veröffentlicht in:	Nature cell biology 2001-02, Vol.3 (2), p.198-203
Hauptverfasser:	Bernards, René, Peeper, Daniel S, Dannenberg, Jan-Hermen, Douma, Sirith, Riele, Hein te
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Blotting, Western Cell Division Cell Transformation, Neoplastic Cells, Cultured Cellular Senescence - genetics Cellular Senescence - physiology Cloning Fibroblasts G proteins Gene Expression Regulation Genes Genes, ras Genes, Retinoblastoma Genetic aspects Growth Inhibitors - genetics Growth Inhibitors - metabolism Humans Mice Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism p107 protein Physiological aspects Proteins Proteins - genetics Proteins - metabolism RB gene Retinoblastoma Retinoblastoma-Like Protein p107 Retroviridae - genetics Retroviridae - metabolism Senescence Signal Transduction Tumor suppressor genes Tumor Suppressor Protein p14ARF Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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