Attenuation of Mycobacterium tuberculosis Functionally Disrupted in a Fatty Acyl-Coenzyme A Synthetase Gene fadD5

One key adaptation that Mycobacterium tuberculosis established to survive long term in vivo is a reliance on lipids as an energy source. M. tuberculosis H37Rv has 36 fadD genes annotated as putative fatty acyl-coenzyme A (CoA) synthetase genes, which encode enzymes that activate fatty acids for meta...

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Veröffentlicht in:	The Journal of infectious diseases 2010-04, Vol.201 (8), p.1232-1239
Hauptverfasser:	Dunphy, Kathleen Y., Senaratne, Ryan H., Masuzawa, Mamiko, Kendall, Lon V., Riley, Lee W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Coenzyme A Ligases - genetics Culture Media Cytokines - biosynthesis Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Genes, Bacterial - genetics Genes, Bacterial - physiology Infectious diseases Lung - pathology Macrophages - physiology Medical sciences Mice Mice, Inbred C57BL Microbiology Miscellaneous Mutagenesis, Site-Directed Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycolic Acids - metabolism Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology
Online-Zugang:	Volltext
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