Expression of p27, P21 super(WAF/Cip1), and p16 super(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma

Expression of p27, P21 super(WAF/Cip1), and p16 super(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma

Aim: To characterize the immunohistochemical expression of p27, p21 super(WAF/Cip1) and p16 super(INK4a) in normal oral epithelium, oral squamous papilloma and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for p27, p21 super(WAF/Cip1) and p16 super(INK4a) was eval...

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Veröffentlicht in:Anticancer research 2010-07, Vol.30 (7), p.2799-2804
Hauptverfasser: Queiroz, AB, Focchi, G, Dobo, C, Gomes, T S, Ribeiro, DA, Oshima, CTF
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container_issue 7
container_start_page 2799
container_title Anticancer research
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creator Queiroz, AB
Focchi, G
Dobo, C
Gomes, T S
Ribeiro, DA
Oshima, CTF
description Aim: To characterize the immunohistochemical expression of p27, p21 super(WAF/Cip1) and p16 super(INK4a) in normal oral epithelium, oral squamous papilloma and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for p27, p21 super(WAF/Cip1) and p16 super(INK4a) was evaluated in 32 samples of normal oral squamous epithelium, 30 samples of oral squamous papilloma, and 34 samples of oral squamous cell carcinoma. Results: Statistically significant differences (p0.05) were noticed. In the same way, no significant statistically differences (p>0.05) were observed for p16 super(INK4a) among groups. Conclusion: Taken together, these findings indicate that p27 is closely involved in malignant transformation of oral mucosa cells, and may be a reliable biomarker for this purpose.
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Materials and Methods: Immunohistochemical staining for p27, p21 super(WAF/Cip1) and p16 super(INK4a) was evaluated in 32 samples of normal oral squamous epithelium, 30 samples of oral squamous papilloma, and 34 samples of oral squamous cell carcinoma. Results: Statistically significant differences (p&lt;0.05) were found in p27 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Regarding p21 super(WAF/Cip1) expression, no statistically significant differences (p&gt;0.05) were noticed. In the same way, no significant statistically differences (p&gt;0.05) were observed for p16 super(INK4a) among groups. 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title Expression of p27, P21 super(WAF/Cip1), and p16 super(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma
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