Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis
Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonst...
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| Veröffentlicht in: | FEBS letters 2010-06, Vol.584 (11), p.2445-2454 |
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| creator | Choi, Hong-Hee Shin, Dong-Min Kang, Gun Kim, Ki-Hye Park, Jin Bong Hur, Gang Min Lee, Hye-Mi Lim, Yun-Ji Park, Jeong-Kyu Jo, Eun-Kyeong Song, Chang-Hwa |
| description | Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis. |
| doi_str_mv | 10.1016/j.febslet.2010.04.050 |
| format | Article |
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The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2010.04.050</identifier><identifier>PMID: 20416295</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Antigens, Bacterial - metabolism ; Apoptosis ; Bacterial Proteins - metabolism ; Endoplasmic Reticulum - metabolism ; Endoplasmic reticulum stress ; Humans ; Infection ; Macrophages - metabolism ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - metabolism ; Proteins - metabolism ; Reactive Oxygen Species - metabolism ; Tuberculosis - metabolism</subject><ispartof>FEBS letters, 2010-06, Vol.584 (11), p.2445-2454</ispartof><rights>2010 Federation of European Biochemical Societies</rights><rights>FEBS Letters 584 (2010) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright 2010 Federation of European Biochemical Societies. 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The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis.</description><subject>Animals</subject><subject>Antigens, Bacterial - metabolism</subject><subject>Apoptosis</subject><subject>Bacterial Proteins - metabolism</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Endoplasmic reticulum stress</subject><subject>Humans</subject><subject>Infection</subject><subject>Macrophages - metabolism</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - metabolism</subject><subject>Proteins - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Tuberculosis - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokPhJ4CyY5XBzzxWqFRTWqmIRcvacuwbyaMkTm1nqvn33GiGbsvK9tE5x9f-CPnM6JZRVn3bb3vo0gB5yylqVG6pom_IhjW1KIWsmrdkQymTpapbcUE-pLSneG5Y-55ccCpZxVu1IU-7yYV5MGn0toiQvV2GZSxSjpASCmkOU4LCp8JPhzAcwOGm-HW0oTM2Q_RozksHEXMhoW2OIQNadg9Xj2VVjuC8yZgyc5jz6vhI3vVmSPDpvF6SPze7x-vb8v73z7vrq_vSKl7zsuqU63ou29pJIWVVOUVRM47VphW2b1CQouqYtBRfC643phZGdr0VVvZKXJKvp16c6GmBlPXok4VhMBOEJemG1lyphopXnbUQomWiXTvVyWljSClCr-foRxOPmlG9YtF7fcaiVyyaSo1YMPflfMPS4Y-8pP5xQMPtyfDsBzj-X6u-2f3gDyvjFTFDukIojlXfT1WAn3vwEHWyHiaLICLYrF3wr0z7F4tvuGs</recordid><startdate>20100603</startdate><enddate>20100603</enddate><creator>Choi, Hong-Hee</creator><creator>Shin, Dong-Min</creator><creator>Kang, Gun</creator><creator>Kim, Ki-Hye</creator><creator>Park, Jin Bong</creator><creator>Hur, Gang Min</creator><creator>Lee, Hye-Mi</creator><creator>Lim, Yun-Ji</creator><creator>Park, Jeong-Kyu</creator><creator>Jo, Eun-Kyeong</creator><creator>Song, Chang-Hwa</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20100603</creationdate><title>Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis</title><author>Choi, Hong-Hee ; 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| subjects | Animals Antigens, Bacterial - metabolism Apoptosis Bacterial Proteins - metabolism Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress Humans Infection Macrophages - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - metabolism Proteins - metabolism Reactive Oxygen Species - metabolism Tuberculosis - metabolism |
| title | Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis |
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