Calcium-containing mitochondrial granules in neurohypophysial axon terminals disappear following vasopressin treatment of brattleboro rats

The presence of intramitochondrial calcium-containing electron-dense granules was demonstrated in axon terminals of chronically hyperactive neurosecretory neurons of untreated homozygous Brattleboro rats. Following vasopressin treatment for 30 days, which has been shown to attenuate this neuronal hy...

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Veröffentlicht in:	Neuroscience letters 1983-08, Vol.39 (2), p.181-185
Hauptverfasser:	KARCSU, S, LASZLO, F. A, TOTH, L, JANCSO, G, BACSY, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - physiology Biological and medical sciences Brattleboro rat calcium Calcium - physiology cytochemistry Cytoplasmic Granules - physiology Cytoplasmic Granules - ultrastructure Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Mitochondria - physiology Mitochondria - ultrastructure Nerve Endings - physiology neurohypophysis neuronal activity Pituitary Gland, Posterior - physiology Pituitary Gland, Posterior - ultrastructure Rats Rats, Brattleboro - physiology Rats, Mutant Strains - physiology vasopressin treatment Vasopressins - pharmacology Vertebrates: endocrinology X-ray microanalysis
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Zusammenfassung:	The presence of intramitochondrial calcium-containing electron-dense granules was demonstrated in axon terminals of chronically hyperactive neurosecretory neurons of untreated homozygous Brattleboro rats. Following vasopressin treatment for 30 days, which has been shown to attenuate this neuronal hyperactivity, calcium-containing deposits could not be detected in mitochondria. It is concluded that the presence of intramitochondrial calcium-containing dense deposits is connected with the functional state of neurosecretory neurons.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(83)90074-5