β-adrenergic sweat responses in cystic fibrosis heterozygotes with without the ΔF508 allele

Cystic fibrosis (CF) causes early death for most homozygotes, yet has a carrier frequency among Caucasians of about 4-5%, suggesting a heterozygote advantage. The major defect in the CF gene is a three-base deletion leading to loss of a phenylalanine residue at position 508 (delta F508) that account...

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Veröffentlicht in:Pediatric research 1991-06, Vol.29 (6), p.525-528
Hauptverfasser: JOHNSON, J. P, LOUIE, E, LEWISTON, N. J, WINE, J. J
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Sprache:eng
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