Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family
The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that o...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 1991-07, Vol.286 (1-2), p.193-200 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 200 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 193 |
| container_title | FEBS letters |
| container_volume | 286 |
| creator | Wittka, Reilinde Stocker, Martin Boheim, Günther Pongs, Olaf |
| description | The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6. |
| doi_str_mv | 10.1016/0014-5793(91)80972-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80721888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014579391809726</els_id><sourcerecordid>80721888</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4816-7768317d376ef33d08712b29b80bc2be1c1f87a4cf7ccf1817d39564cb59c0563</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EKtvCPwDJF1A5BDxx4o9LJai6gFTEAThbjjPWGpJ4sZNF--9JmhVwAk7WzPt4Pt4h5Amwl8BAvGIMqqKWml9qeKGYlmUh7pENKMkLXgl1n2x-IQ_Jec5f2Rwr0GfkDDSTtYQN2X2IHbqps4k2NodMfUy0Dd5jwmGkyY6YafQ0oYsHTEfqU-xpGKwbw8GOIQ5zQMcd0k87-w0T3cfR5hymnrqdHQbsqLd96I6PyANvu4yPT-8F-bK9-Xz9rrj9-Pb99evbwlUKRCGlUBxky6VAz3nLlISyKXWjWOPKBsGBV9JWzkvn_LzNjOpaVK6ptWO14Bfk-Vp3n-L3CfNo-pAddp0dME7ZKCZLUEr9EwTBawFVOYPVCroUc07ozT6F3qajAWaWS5jFZrPYbDSYu0uYZZCnp_pT02P7-9Nq_aw_O-k2O9v5ZAcX8h-YqriUcua2K_cjdHj8r95me_OmXIQlr-Euuwx0tRbC2f5DwGSyCzg4bMN83dG0Mfx9o5-SAbhu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16356142</pqid></control><display><type>article</type><title>Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Wittka, Reilinde ; Stocker, Martin ; Boheim, Günther ; Pongs, Olaf</creator><creatorcontrib>Wittka, Reilinde ; Stocker, Martin ; Boheim, Günther ; Pongs, Olaf</creatorcontrib><description>The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(91)80972-6</identifier><identifier>PMID: 1907571</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>alanine ; Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; C-terminus ; CDNA derived mRNA ; Cell Membrane - metabolism ; Cell physiology ; channels ; cRNA ; DNA ; DNA Mutational Analysis ; Drosophila ; Drosophila melanogaster ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; inactivation ; Kinetics ; Macro-patch recording ; Membrane and intracellular transports ; Molecular and cellular biology ; Molecular Sequence Data ; potassium ; Potassium channel ; Potassium Channels - genetics ; Potassium Channels - metabolism ; requirements ; Sequence Alignment ; Shaker ; Shaker protein ; Xenopus oocyte</subject><ispartof>FEBS letters, 1991-07, Vol.286 (1-2), p.193-200</ispartof><rights>1991</rights><rights>FEBS Letters 286 (1991) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4816-7768317d376ef33d08712b29b80bc2be1c1f87a4cf7ccf1817d39564cb59c0563</citedby><cites>FETCH-LOGICAL-c4816-7768317d376ef33d08712b29b80bc2be1c1f87a4cf7ccf1817d39564cb59c0563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(91)80972-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19843777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1907571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wittka, Reilinde</creatorcontrib><creatorcontrib>Stocker, Martin</creatorcontrib><creatorcontrib>Boheim, Günther</creatorcontrib><creatorcontrib>Pongs, Olaf</creatorcontrib><title>Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.</description><subject>alanine</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>C-terminus</subject><subject>CDNA derived mRNA</subject><subject>Cell Membrane - metabolism</subject><subject>Cell physiology</subject><subject>channels</subject><subject>cRNA</subject><subject>DNA</subject><subject>DNA Mutational Analysis</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>inactivation</subject><subject>Kinetics</subject><subject>Macro-patch recording</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>potassium</subject><subject>Potassium channel</subject><subject>Potassium Channels - genetics</subject><subject>Potassium Channels - metabolism</subject><subject>requirements</subject><subject>Sequence Alignment</subject><subject>Shaker</subject><subject>Shaker protein</subject><subject>Xenopus oocyte</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EKtvCPwDJF1A5BDxx4o9LJai6gFTEAThbjjPWGpJ4sZNF--9JmhVwAk7WzPt4Pt4h5Amwl8BAvGIMqqKWml9qeKGYlmUh7pENKMkLXgl1n2x-IQ_Jec5f2Rwr0GfkDDSTtYQN2X2IHbqps4k2NodMfUy0Dd5jwmGkyY6YafQ0oYsHTEfqU-xpGKwbw8GOIQ5zQMcd0k87-w0T3cfR5hymnrqdHQbsqLd96I6PyANvu4yPT-8F-bK9-Xz9rrj9-Pb99evbwlUKRCGlUBxky6VAz3nLlISyKXWjWOPKBsGBV9JWzkvn_LzNjOpaVK6ptWO14Bfk-Vp3n-L3CfNo-pAddp0dME7ZKCZLUEr9EwTBawFVOYPVCroUc07ozT6F3qajAWaWS5jFZrPYbDSYu0uYZZCnp_pT02P7-9Nq_aw_O-k2O9v5ZAcX8h-YqriUcua2K_cjdHj8r95me_OmXIQlr-Euuwx0tRbC2f5DwGSyCzg4bMN83dG0Mfx9o5-SAbhu</recordid><startdate>19910729</startdate><enddate>19910729</enddate><creator>Wittka, Reilinde</creator><creator>Stocker, Martin</creator><creator>Boheim, Günther</creator><creator>Pongs, Olaf</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19910729</creationdate><title>Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family</title><author>Wittka, Reilinde ; Stocker, Martin ; Boheim, Günther ; Pongs, Olaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4816-7768317d376ef33d08712b29b80bc2be1c1f87a4cf7ccf1817d39564cb59c0563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>alanine</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>C-terminus</topic><topic>CDNA derived mRNA</topic><topic>Cell Membrane - metabolism</topic><topic>Cell physiology</topic><topic>channels</topic><topic>cRNA</topic><topic>DNA</topic><topic>DNA Mutational Analysis</topic><topic>Drosophila</topic><topic>Drosophila melanogaster</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>inactivation</topic><topic>Kinetics</topic><topic>Macro-patch recording</topic><topic>Membrane and intracellular transports</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>potassium</topic><topic>Potassium channel</topic><topic>Potassium Channels - genetics</topic><topic>Potassium Channels - metabolism</topic><topic>requirements</topic><topic>Sequence Alignment</topic><topic>Shaker</topic><topic>Shaker protein</topic><topic>Xenopus oocyte</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wittka, Reilinde</creatorcontrib><creatorcontrib>Stocker, Martin</creatorcontrib><creatorcontrib>Boheim, Günther</creatorcontrib><creatorcontrib>Pongs, Olaf</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wittka, Reilinde</au><au>Stocker, Martin</au><au>Boheim, Günther</au><au>Pongs, Olaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1991-07-29</date><risdate>1991</risdate><volume>286</volume><issue>1-2</issue><spage>193</spage><epage>200</epage><pages>193-200</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1907571</pmid><doi>10.1016/0014-5793(91)80972-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1991-07, Vol.286 (1-2), p.193-200 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80721888 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | alanine Amino Acid Sequence Animals Base Sequence Biological and medical sciences C-terminus CDNA derived mRNA Cell Membrane - metabolism Cell physiology channels cRNA DNA DNA Mutational Analysis Drosophila Drosophila melanogaster Electrophysiology Fundamental and applied biological sciences. Psychology inactivation Kinetics Macro-patch recording Membrane and intracellular transports Molecular and cellular biology Molecular Sequence Data potassium Potassium channel Potassium Channels - genetics Potassium Channels - metabolism requirements Sequence Alignment Shaker Shaker protein Xenopus oocyte |
| title | Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T10%3A48%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20basis%20for%20different%20rates%20of%20recovery%20from%20inactivation%20in%20the%20Shaker%20potassium%20channel%20family&rft.jtitle=FEBS%20letters&rft.au=Wittka,%20Reilinde&rft.date=1991-07-29&rft.volume=286&rft.issue=1-2&rft.spage=193&rft.epage=200&rft.pages=193-200&rft.issn=0014-5793&rft.eissn=1873-3468&rft.coden=FEBLAL&rft_id=info:doi/10.1016/0014-5793(91)80972-6&rft_dat=%3Cproquest_cross%3E80721888%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16356142&rft_id=info:pmid/1907571&rft_els_id=0014579391809726&rfr_iscdi=true |