Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family

The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that o...

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Veröffentlicht in:	FEBS letters 1991-07, Vol.286 (1-2), p.193-200
Hauptverfasser:	Wittka, Reilinde, Stocker, Martin, Boheim, Günther, Pongs, Olaf
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine Amino Acid Sequence Animals Base Sequence Biological and medical sciences C-terminus CDNA derived mRNA Cell Membrane - metabolism Cell physiology channels cRNA DNA DNA Mutational Analysis Drosophila Drosophila melanogaster Electrophysiology Fundamental and applied biological sciences. Psychology inactivation Kinetics Macro-patch recording Membrane and intracellular transports Molecular and cellular biology Molecular Sequence Data potassium Potassium channel Potassium Channels - genetics Potassium Channels - metabolism requirements Sequence Alignment Shaker Shaker protein Xenopus oocyte
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Zusammenfassung:	The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(91)80972-6