Effects of Two α-Adrenoceptor Antagonists, Nicergoline and Phentolamine, on Myocardial Oxygen Consumption in the Dog
We compared the effects of two α-adrenoceptor antagonists, nicergoline and phentolamine, on myocardial oxygen consumption (MVO2) in open-chest dogs. Intravenous nicergoline, 2 μg/kg/min for 30 min. reduced blood pressure from 130 ± 6 to 100 ± 2 mm Hg. did not change heart rate, and reduced MVO2/beat...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1983-09, Vol.5 (5), p.856-860 |
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| creator | Lièvre, M Kofman, J Andrieu, J L Faucon, G |
| description | We compared the effects of two α-adrenoceptor antagonists, nicergoline and phentolamine, on myocardial oxygen consumption (MVO2) in open-chest dogs. Intravenous nicergoline, 2 μg/kg/min for 30 min. reduced blood pressure from 130 ± 6 to 100 ± 2 mm Hg. did not change heart rate, and reduced MVO2/beat from 63.1 ± 6.6 to 43.6 ± 4.0 μl (p < 0.05, compared with control saline-infused and phentolamine-treated dogs). Intravenous phentolamine, 8 μg/kg/min, reduced blood pressure from 123 ± 6 to 95 ± 8 mm Hg and increased heart rate from 199 ± 4 to 235 ± 9 beats/min (p < 0.05, compared with control and nicergoline-treated dogs). MVO2/beat did not change, but MVO2 increased from 11.1 ± 1.5 to 13.1 ± 2.0 ml/min (p < 0.05, compared with nicergoline-treated dogs). These results suggest that nicergoline may be perferable to phentolamine in patients in whom it is important to avoid any increase in MVO2. |
| doi_str_mv | 10.1097/00005344-198309000-00023 |
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Intravenous nicergoline, 2 μg/kg/min for 30 min. reduced blood pressure from 130 ± 6 to 100 ± 2 mm Hg. did not change heart rate, and reduced MVO2/beat from 63.1 ± 6.6 to 43.6 ± 4.0 μl (p < 0.05, compared with control saline-infused and phentolamine-treated dogs). Intravenous phentolamine, 8 μg/kg/min, reduced blood pressure from 123 ± 6 to 95 ± 8 mm Hg and increased heart rate from 199 ± 4 to 235 ± 9 beats/min (p < 0.05, compared with control and nicergoline-treated dogs). MVO2/beat did not change, but MVO2 increased from 11.1 ± 1.5 to 13.1 ± 2.0 ml/min (p < 0.05, compared with nicergoline-treated dogs). These results suggest that nicergoline may be perferable to phentolamine in patients in whom it is important to avoid any increase in MVO2.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198309000-00023</identifier><identifier>PMID: 6195476</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Adrenergic alpha-Antagonists - pharmacology ; Animals ; Blood Pressure - drug effects ; Dogs ; Ergolines - pharmacology ; Female ; Heart Rate - drug effects ; Male ; Myocardium - metabolism ; Nicergoline - pharmacology ; Oxygen Consumption - drug effects ; Phentolamine - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 1983-09, Vol.5 (5), p.856-860</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3203-741ed9f90e69c3ead0de8ffd3c2ca86b0a59184d5a78d9090e0a7bddb40959163</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00005344-198309000-00023$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198309000-00023$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6195476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lièvre, M</creatorcontrib><creatorcontrib>Kofman, J</creatorcontrib><creatorcontrib>Andrieu, J L</creatorcontrib><creatorcontrib>Faucon, G</creatorcontrib><title>Effects of Two α-Adrenoceptor Antagonists, Nicergoline and Phentolamine, on Myocardial Oxygen Consumption in the Dog</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>We compared the effects of two α-adrenoceptor antagonists, nicergoline and phentolamine, on myocardial oxygen consumption (MVO2) in open-chest dogs. Intravenous nicergoline, 2 μg/kg/min for 30 min. reduced blood pressure from 130 ± 6 to 100 ± 2 mm Hg. did not change heart rate, and reduced MVO2/beat from 63.1 ± 6.6 to 43.6 ± 4.0 μl (p < 0.05, compared with control saline-infused and phentolamine-treated dogs). Intravenous phentolamine, 8 μg/kg/min, reduced blood pressure from 123 ± 6 to 95 ± 8 mm Hg and increased heart rate from 199 ± 4 to 235 ± 9 beats/min (p < 0.05, compared with control and nicergoline-treated dogs). MVO2/beat did not change, but MVO2 increased from 11.1 ± 1.5 to 13.1 ± 2.0 ml/min (p < 0.05, compared with nicergoline-treated dogs). These results suggest that nicergoline may be perferable to phentolamine in patients in whom it is important to avoid any increase in MVO2.</description><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Dogs</subject><subject>Ergolines - pharmacology</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Myocardium - metabolism</subject><subject>Nicergoline - pharmacology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Phentolamine - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEQxy1EVULhEZB84tSF8dr74WMUyodUaA_lbDn2bLLgtYPtVZrH4kX6TBgSeqsla8bz_8-M9DMhlME7BrJ7D-U0XIiKyZ6DLK-q3Jo_IwvWcF6Jkj8nC2AtVLUQ7QvyMqUfAEw0XXtOzlsmG9G1CzJfDQOanGgY6N0-0Iff1dJG9MHgLodIlz7rTfBjyumSfhsNxk1wo0eqvaW3W_Q5OD2VwiUNnn49BKOjHbWjN_eHDXq6Cj7N0y6PRR09zVukH8LmFTkbtEv4-hQvyPePV3erz9X1zacvq-V1ZXgNvOoEQysHCdhKw1FbsNgPg-WmNrpv16AbyXphG931VhYMCLpbW7sWIIvS8gvy9jh3F8OvGVNW05gMOqc9hjmpHrqaAePF2B-NJoaUIg5qF8dJx4NioP4SV_-Jq0fi6h_x0vrmtGNeT2gfG0-Iiy6O-j64jDH9dPMeo9qidnmrnvpI_gfEc408</recordid><startdate>198309</startdate><enddate>198309</enddate><creator>Lièvre, M</creator><creator>Kofman, J</creator><creator>Andrieu, J L</creator><creator>Faucon, G</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198309</creationdate><title>Effects of Two α-Adrenoceptor Antagonists, Nicergoline and Phentolamine, on Myocardial Oxygen Consumption in the Dog</title><author>Lièvre, M ; Kofman, J ; Andrieu, J L ; Faucon, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3203-741ed9f90e69c3ead0de8ffd3c2ca86b0a59184d5a78d9090e0a7bddb40959163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Dogs</topic><topic>Ergolines - pharmacology</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Myocardium - metabolism</topic><topic>Nicergoline - pharmacology</topic><topic>Oxygen Consumption - drug effects</topic><topic>Phentolamine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lièvre, M</creatorcontrib><creatorcontrib>Kofman, J</creatorcontrib><creatorcontrib>Andrieu, J L</creatorcontrib><creatorcontrib>Faucon, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lièvre, M</au><au>Kofman, J</au><au>Andrieu, J L</au><au>Faucon, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Two α-Adrenoceptor Antagonists, Nicergoline and Phentolamine, on Myocardial Oxygen Consumption in the Dog</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1983-09</date><risdate>1983</risdate><volume>5</volume><issue>5</issue><spage>856</spage><epage>860</epage><pages>856-860</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>We compared the effects of two α-adrenoceptor antagonists, nicergoline and phentolamine, on myocardial oxygen consumption (MVO2) in open-chest dogs. Intravenous nicergoline, 2 μg/kg/min for 30 min. reduced blood pressure from 130 ± 6 to 100 ± 2 mm Hg. did not change heart rate, and reduced MVO2/beat from 63.1 ± 6.6 to 43.6 ± 4.0 μl (p < 0.05, compared with control saline-infused and phentolamine-treated dogs). Intravenous phentolamine, 8 μg/kg/min, reduced blood pressure from 123 ± 6 to 95 ± 8 mm Hg and increased heart rate from 199 ± 4 to 235 ± 9 beats/min (p < 0.05, compared with control and nicergoline-treated dogs). MVO2/beat did not change, but MVO2 increased from 11.1 ± 1.5 to 13.1 ± 2.0 ml/min (p < 0.05, compared with nicergoline-treated dogs). These results suggest that nicergoline may be perferable to phentolamine in patients in whom it is important to avoid any increase in MVO2.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>6195476</pmid><doi>10.1097/00005344-198309000-00023</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic alpha-Antagonists - pharmacology Animals Blood Pressure - drug effects Dogs Ergolines - pharmacology Female Heart Rate - drug effects Male Myocardium - metabolism Nicergoline - pharmacology Oxygen Consumption - drug effects Phentolamine - pharmacology |
| title | Effects of Two α-Adrenoceptor Antagonists, Nicergoline and Phentolamine, on Myocardial Oxygen Consumption in the Dog |
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