Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats

Prophylactic insulin administration is known to prevent hyperglycaemia in diabetes prone BB rats and non-obese diabetic mice. This study investigated the effect of insulin treatment on the development of overt diabetes, clinically inapparent anti-islet autoreactivity, and thyroiditis in RT6-depleted...

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Veröffentlicht in:	Diabetologia 1991-05, Vol.34 (5), p.296-300
Hauptverfasser:	GOTTLIEB, P. A, HANDLER, E. S, APPEL, M. C, GREINER, D. L, MORDES, J. P, ROSSINI, A. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Autoantibodies - analysis Biological and medical sciences Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control Endocrine pancreas. Apud cells (diseases) Endocrinopathies Immunity, Innate Immunophenotyping Immunotherapy, Adoptive Insulin - therapeutic use Islets of Langerhans - immunology Lymphocyte Depletion Medical sciences Rats Rats, Inbred BB T-Lymphocytes - immunology Thyroiditis - immunology
Online-Zugang:	Volltext
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