Estrogen and progesterone receptors in human ovarian tumors
Estrogen and progesterone receptors were measured in cystosols prepared from 32 normal ovaries and 25 benign and 49 malignant ovarian tumors. In normal ovarian tissue, estrogen and progesterone receptors were detected in 22 and 75% of specimens, respectively. Estrogen receptors were present in low c...
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| Veröffentlicht in: | Gynecologic oncology 1983-01, Vol.16 (2), p.246-253 |
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| container_title | Gynecologic oncology |
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| creator | Willcocks, D. Toppila, M. Hudson, C.N. Tyler, J.P.P. Baird, P.J. Eastman, C.J. |
| description | Estrogen and progesterone receptors were measured in cystosols prepared from 32 normal ovaries and 25 benign and 49 malignant ovarian tumors. In normal ovarian tissue, estrogen and progesterone receptors were detected in 22 and 75% of specimens, respectively. Estrogen receptors were present in low concentrations ranging from 2 to 9 fmol/mg cytosol protein. The estrogen receptor content and distribution were similar in benign tumors (20%), but progesterone receptors were significantly decreased in 16% of specimens (
P < 0.001). In malignant ovarian tissues, estrogen receptors were present in 57% of specimens in concentrations ranging from 1 to 132 fmol/mg cytosol protein. Of these, 72% of tissues had estrogen-receptor concentrations greater than 10 fmol/mg cytosol protein. The presence of estrogen receptors in ovarian cancer was significantly different from normal ovaries and benign tumor tissues (
P < 0.01). Progesterone receptors were detectable in 29% of ovarian cancer specimens. Estrogen and progesterone receptors were present alone or in combination, in 65% of ovarian cancers. The similarity in sex steroid content between ovarian and breast cancer warrants prospective studies of sex steroid receptor content in ovarian malignancies as a possible predictive index of survival and response to hormone therapy. |
| doi_str_mv | 10.1016/0090-8258(83)90099-9 |
| format | Article |
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P < 0.001). In malignant ovarian tissues, estrogen receptors were present in 57% of specimens in concentrations ranging from 1 to 132 fmol/mg cytosol protein. Of these, 72% of tissues had estrogen-receptor concentrations greater than 10 fmol/mg cytosol protein. The presence of estrogen receptors in ovarian cancer was significantly different from normal ovaries and benign tumor tissues (
P < 0.01). Progesterone receptors were detectable in 29% of ovarian cancer specimens. Estrogen and progesterone receptors were present alone or in combination, in 65% of ovarian cancers. The similarity in sex steroid content between ovarian and breast cancer warrants prospective studies of sex steroid receptor content in ovarian malignancies as a possible predictive index of survival and response to hormone therapy.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/0090-8258(83)90099-9</identifier><identifier>PMID: 6313494</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adenocarcinoma, Mucinous - analysis ; Biological and medical sciences ; Carcinoma, Papillary - analysis ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Ovarian Neoplasms - analysis ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Tumors ; Uterine Neoplasms - analysis</subject><ispartof>Gynecologic oncology, 1983-01, Vol.16 (2), p.246-253</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-902f6e022b938f06fbac28667ec5022eb803762d4cc7e41fe725300c3e77513</citedby><cites>FETCH-LOGICAL-c415t-902f6e022b938f06fbac28667ec5022eb803762d4cc7e41fe725300c3e77513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0090825883900999$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9348749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6313494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willcocks, D.</creatorcontrib><creatorcontrib>Toppila, M.</creatorcontrib><creatorcontrib>Hudson, C.N.</creatorcontrib><creatorcontrib>Tyler, J.P.P.</creatorcontrib><creatorcontrib>Baird, P.J.</creatorcontrib><creatorcontrib>Eastman, C.J.</creatorcontrib><title>Estrogen and progesterone receptors in human ovarian tumors</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Estrogen and progesterone receptors were measured in cystosols prepared from 32 normal ovaries and 25 benign and 49 malignant ovarian tumors. In normal ovarian tissue, estrogen and progesterone receptors were detected in 22 and 75% of specimens, respectively. Estrogen receptors were present in low concentrations ranging from 2 to 9 fmol/mg cytosol protein. The estrogen receptor content and distribution were similar in benign tumors (20%), but progesterone receptors were significantly decreased in 16% of specimens (
P < 0.001). In malignant ovarian tissues, estrogen receptors were present in 57% of specimens in concentrations ranging from 1 to 132 fmol/mg cytosol protein. Of these, 72% of tissues had estrogen-receptor concentrations greater than 10 fmol/mg cytosol protein. The presence of estrogen receptors in ovarian cancer was significantly different from normal ovaries and benign tumor tissues (
P < 0.01). Progesterone receptors were detectable in 29% of ovarian cancer specimens. Estrogen and progesterone receptors were present alone or in combination, in 65% of ovarian cancers. The similarity in sex steroid content between ovarian and breast cancer warrants prospective studies of sex steroid receptor content in ovarian malignancies as a possible predictive index of survival and response to hormone therapy.</description><subject>Adenocarcinoma, Mucinous - analysis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Papillary - analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Ovarian Neoplasms - analysis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Tumors</subject><subject>Uterine Neoplasms - analysis</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS6ENFF9SZp2gRBEBkfMOBC9yFNbzUybcekHfDfmzrDLF3d17mHw0fIKYVrCjS_AVCQSibkpeRXKk4qVXtkSkGJNJdC7ZPpTnJIjkL4AgAOlE3IJOeUZyqbktt56H33gW1i2ipZjW3o0XctJh4trvrOh8S1yefQmDbp1sa7WPuhiftjclCbZcCTbZ2Rt8f5-8Nzunh9enm4X6Q2o6JPFbA6R2CsVFzWkNelsUzmeYFWxC2WEniRsyqztsCM1lgwwQEsx6IQlM_IxcY1hvseYjrduGBxuTQtdkPQEgoqlGBRmG2E1ncheKz1yrvG-B9NQY_E9IhDjzi05PqPmFbx7WzrP5QNVrunLaJ4P9_eTbBmWXvTWhd2MsUzWWSjzd1GhpHE2qHXwTpsLVYugux11bn_c_wC4bqGYw</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Willcocks, D.</creator><creator>Toppila, M.</creator><creator>Hudson, C.N.</creator><creator>Tyler, J.P.P.</creator><creator>Baird, P.J.</creator><creator>Eastman, C.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Estrogen and progesterone receptors in human ovarian tumors</title><author>Willcocks, D. ; Toppila, M. ; Hudson, C.N. ; Tyler, J.P.P. ; Baird, P.J. ; Eastman, C.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-902f6e022b938f06fbac28667ec5022eb803762d4cc7e41fe725300c3e77513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adenocarcinoma, Mucinous - analysis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Papillary - analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Ovarian Neoplasms - analysis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Tumors</topic><topic>Uterine Neoplasms - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willcocks, D.</creatorcontrib><creatorcontrib>Toppila, M.</creatorcontrib><creatorcontrib>Hudson, C.N.</creatorcontrib><creatorcontrib>Tyler, J.P.P.</creatorcontrib><creatorcontrib>Baird, P.J.</creatorcontrib><creatorcontrib>Eastman, C.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willcocks, D.</au><au>Toppila, M.</au><au>Hudson, C.N.</au><au>Tyler, J.P.P.</au><au>Baird, P.J.</au><au>Eastman, C.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen and progesterone receptors in human ovarian tumors</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>16</volume><issue>2</issue><spage>246</spage><epage>253</epage><pages>246-253</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>Estrogen and progesterone receptors were measured in cystosols prepared from 32 normal ovaries and 25 benign and 49 malignant ovarian tumors. In normal ovarian tissue, estrogen and progesterone receptors were detected in 22 and 75% of specimens, respectively. Estrogen receptors were present in low concentrations ranging from 2 to 9 fmol/mg cytosol protein. The estrogen receptor content and distribution were similar in benign tumors (20%), but progesterone receptors were significantly decreased in 16% of specimens (
P < 0.001). In malignant ovarian tissues, estrogen receptors were present in 57% of specimens in concentrations ranging from 1 to 132 fmol/mg cytosol protein. Of these, 72% of tissues had estrogen-receptor concentrations greater than 10 fmol/mg cytosol protein. The presence of estrogen receptors in ovarian cancer was significantly different from normal ovaries and benign tumor tissues (
P < 0.01). Progesterone receptors were detectable in 29% of ovarian cancer specimens. Estrogen and progesterone receptors were present alone or in combination, in 65% of ovarian cancers. The similarity in sex steroid content between ovarian and breast cancer warrants prospective studies of sex steroid receptor content in ovarian malignancies as a possible predictive index of survival and response to hormone therapy.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>6313494</pmid><doi>10.1016/0090-8258(83)90099-9</doi><tpages>8</tpages></addata></record> |
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| ispartof | Gynecologic oncology, 1983-01, Vol.16 (2), p.246-253 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenocarcinoma, Mucinous - analysis Biological and medical sciences Carcinoma, Papillary - analysis Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Ovarian Neoplasms - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tumors Uterine Neoplasms - analysis |
| title | Estrogen and progesterone receptors in human ovarian tumors |
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