Simplified quantitative estimation in vitro of lymphocyte radiosensitivity applied to patients with chronic lymphocytic leukaemia
Lymphocyte survival changes observed at 1, 2 and 3 days as responses to 3 doses of ionising radiation in vitro (40, 100, and 500 cGy) are analysed by computer according to a simple (single cell population) mathematical model. Intrinsic radiosensitivity, the susceptibility to lethal injury, which is...
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Veröffentlicht in: | Leukemia research 1991, Vol.15 (7), p.577-589 |
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creator | Thomson, Alasdair E.R. Wetherley-Mein, Gordon O'Connor, Thomas W.E. Still, Beverley Peel, William E. Slater, Nicolas G.P. Bates, Thelma |
description | Lymphocyte survival changes observed at 1, 2 and 3 days as responses to 3 doses of ionising radiation
in vitro (40, 100, and 500 cGy) are analysed by computer according to a simple (single cell population) mathematical model. Intrinsic radiosensitivity, the susceptibility to lethal injury, which is expressed as the
D
37 value (the radiation dose permitting 37% survival), is estimated separately from the kinetics of subsequent death of lethally-irradiated cells (expressed as their half-life, or
t
1
2
value). Among the 35 patients with B-cell CLL studied (15 were never treated), both parameters varied widely and independently of one another,
t
1
2
ranged from 9–200 h and above,
D
37 from 14–500 cGy or above. Twenty-three patients were deemed ‘radiosensitive’ (
D
37 below 110 cGy).
D
37 level did not correlate with treatment status, mode of treatment, clinical staging (Rai) or lymphocyte count. With some exceptions,
D
37 remained relatively constant for individual patients with increasing duration of disease or alterations in treatment status. The assay method may prove useful as an aid in predicting response to low-dose splenic irradiation (SI) in CLL. |
doi_str_mv | 10.1016/0145-2126(91)90026-P |
format | Article |
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in vitro (40, 100, and 500 cGy) are analysed by computer according to a simple (single cell population) mathematical model. Intrinsic radiosensitivity, the susceptibility to lethal injury, which is expressed as the
D
37 value (the radiation dose permitting 37% survival), is estimated separately from the kinetics of subsequent death of lethally-irradiated cells (expressed as their half-life, or
t
1
2
value). Among the 35 patients with B-cell CLL studied (15 were never treated), both parameters varied widely and independently of one another,
t
1
2
ranged from 9–200 h and above,
D
37 from 14–500 cGy or above. Twenty-three patients were deemed ‘radiosensitive’ (
D
37 below 110 cGy).
D
37 level did not correlate with treatment status, mode of treatment, clinical staging (Rai) or lymphocyte count. With some exceptions,
D
37 remained relatively constant for individual patients with increasing duration of disease or alterations in treatment status. The assay method may prove useful as an aid in predicting response to low-dose splenic irradiation (SI) in CLL.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(91)90026-P</identifier><identifier>PMID: 1861541</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>B-Lymphocytes - pathology ; B-Lymphocytes - radiation effects ; Biological and medical sciences ; cell death rate ; Cell Survival - radiation effects ; Chronic lymphocytic leukaemia ; colchicine ultrasensitivity ; Computer Simulation ; Hemopathies ; Humans ; interphase death ; intrinsic radiosensitivity ; Leukemia, Lymphocytic, Chronic, B-Cell - blood ; Leukemia, Lymphocytic, Chronic, B-Cell - pathology ; Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy ; low-dose splenic radiotherapy ; lymphocytes ; Lymphocytes - pathology ; Lymphocytes - radiation effects ; Mathematical Computing ; Medical sciences ; Models, Biological ; Radiation Tolerance ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Time Factors</subject><ispartof>Leukemia research, 1991, Vol.15 (7), p.577-589</ispartof><rights>1991</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-3bf9771d4494750430659292d873cd2e3522cd89ad464285fa64dd7e55d49be03</citedby><cites>FETCH-LOGICAL-c332t-3bf9771d4494750430659292d873cd2e3522cd89ad464285fa64dd7e55d49be03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0145-2126(91)90026-P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4714871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1861541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomson, Alasdair E.R.</creatorcontrib><creatorcontrib>Wetherley-Mein, Gordon</creatorcontrib><creatorcontrib>O'Connor, Thomas W.E.</creatorcontrib><creatorcontrib>Still, Beverley</creatorcontrib><creatorcontrib>Peel, William E.</creatorcontrib><creatorcontrib>Slater, Nicolas G.P.</creatorcontrib><creatorcontrib>Bates, Thelma</creatorcontrib><title>Simplified quantitative estimation in vitro of lymphocyte radiosensitivity applied to patients with chronic lymphocytic leukaemia</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Lymphocyte survival changes observed at 1, 2 and 3 days as responses to 3 doses of ionising radiation
in vitro (40, 100, and 500 cGy) are analysed by computer according to a simple (single cell population) mathematical model. Intrinsic radiosensitivity, the susceptibility to lethal injury, which is expressed as the
D
37 value (the radiation dose permitting 37% survival), is estimated separately from the kinetics of subsequent death of lethally-irradiated cells (expressed as their half-life, or
t
1
2
value). Among the 35 patients with B-cell CLL studied (15 were never treated), both parameters varied widely and independently of one another,
t
1
2
ranged from 9–200 h and above,
D
37 from 14–500 cGy or above. Twenty-three patients were deemed ‘radiosensitive’ (
D
37 below 110 cGy).
D
37 level did not correlate with treatment status, mode of treatment, clinical staging (Rai) or lymphocyte count. With some exceptions,
D
37 remained relatively constant for individual patients with increasing duration of disease or alterations in treatment status. The assay method may prove useful as an aid in predicting response to low-dose splenic irradiation (SI) in CLL.</description><subject>B-Lymphocytes - pathology</subject><subject>B-Lymphocytes - radiation effects</subject><subject>Biological and medical sciences</subject><subject>cell death rate</subject><subject>Cell Survival - radiation effects</subject><subject>Chronic lymphocytic leukaemia</subject><subject>colchicine ultrasensitivity</subject><subject>Computer Simulation</subject><subject>Hemopathies</subject><subject>Humans</subject><subject>interphase death</subject><subject>intrinsic radiosensitivity</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - blood</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy</subject><subject>low-dose splenic radiotherapy</subject><subject>lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Lymphocytes - radiation effects</subject><subject>Mathematical Computing</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Radiation Tolerance</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Time Factors</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo6-zqN1DIQUQPrfnfnYsgi6vCggvqOWSSaiba3elN0iNz9Jubdobdm56qoH7vUfUKoWeUvKGEqreECtkwytQrTV9rQphqbh6gDe1a3siOy4doc4c8Ruc5_yCESE31GTqjnaJS0A36_TWM8xD6AB7fLnYqodgS9oAhlzDWNk44THgfSoo49ng4jPMuukMBnKwPMcOUQxWEcsB2rk7Vp0Q8VyVMJeNfoeyw26U4BXcvXntYfloYg32CHvV2yPD0VC_Q96sP3y4_NddfPn6-fH_dOM5Zafi2121LvRBatJIITpTUTDNfz3WeAZeMOd9p64USrJO9VcL7FqT0Qm-B8Av08ug7p3i71PPMGLKDYbATxCWbjrRUKM7_C1JFu04pVUFxBF2KOSfozZxqZulgKDHri8yav1nzN5qavy8yN1X2_OS_bEfw96LjT-r8xWlus7NDn-zkQr7DRF2za1fs3RGDGto-QDLZ1cwd-JDAFeNj-PcefwDdXK_M</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Thomson, Alasdair E.R.</creator><creator>Wetherley-Mein, Gordon</creator><creator>O'Connor, Thomas W.E.</creator><creator>Still, Beverley</creator><creator>Peel, William E.</creator><creator>Slater, Nicolas G.P.</creator><creator>Bates, Thelma</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Simplified quantitative estimation in vitro of lymphocyte radiosensitivity applied to patients with chronic lymphocytic leukaemia</title><author>Thomson, Alasdair E.R. ; Wetherley-Mein, Gordon ; O'Connor, Thomas W.E. ; Still, Beverley ; Peel, William E. ; Slater, Nicolas G.P. ; Bates, Thelma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-3bf9771d4494750430659292d873cd2e3522cd89ad464285fa64dd7e55d49be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>B-Lymphocytes - pathology</topic><topic>B-Lymphocytes - radiation effects</topic><topic>Biological and medical sciences</topic><topic>cell death rate</topic><topic>Cell Survival - radiation effects</topic><topic>Chronic lymphocytic leukaemia</topic><topic>colchicine ultrasensitivity</topic><topic>Computer Simulation</topic><topic>Hemopathies</topic><topic>Humans</topic><topic>interphase death</topic><topic>intrinsic radiosensitivity</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - blood</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy</topic><topic>low-dose splenic radiotherapy</topic><topic>lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Lymphocytes - radiation effects</topic><topic>Mathematical Computing</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Radiation Tolerance</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomson, Alasdair E.R.</creatorcontrib><creatorcontrib>Wetherley-Mein, Gordon</creatorcontrib><creatorcontrib>O'Connor, Thomas W.E.</creatorcontrib><creatorcontrib>Still, Beverley</creatorcontrib><creatorcontrib>Peel, William E.</creatorcontrib><creatorcontrib>Slater, Nicolas G.P.</creatorcontrib><creatorcontrib>Bates, Thelma</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomson, Alasdair E.R.</au><au>Wetherley-Mein, Gordon</au><au>O'Connor, Thomas W.E.</au><au>Still, Beverley</au><au>Peel, William E.</au><au>Slater, Nicolas G.P.</au><au>Bates, Thelma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simplified quantitative estimation in vitro of lymphocyte radiosensitivity applied to patients with chronic lymphocytic leukaemia</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1991</date><risdate>1991</risdate><volume>15</volume><issue>7</issue><spage>577</spage><epage>589</epage><pages>577-589</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Lymphocyte survival changes observed at 1, 2 and 3 days as responses to 3 doses of ionising radiation
in vitro (40, 100, and 500 cGy) are analysed by computer according to a simple (single cell population) mathematical model. Intrinsic radiosensitivity, the susceptibility to lethal injury, which is expressed as the
D
37 value (the radiation dose permitting 37% survival), is estimated separately from the kinetics of subsequent death of lethally-irradiated cells (expressed as their half-life, or
t
1
2
value). Among the 35 patients with B-cell CLL studied (15 were never treated), both parameters varied widely and independently of one another,
t
1
2
ranged from 9–200 h and above,
D
37 from 14–500 cGy or above. Twenty-three patients were deemed ‘radiosensitive’ (
D
37 below 110 cGy).
D
37 level did not correlate with treatment status, mode of treatment, clinical staging (Rai) or lymphocyte count. With some exceptions,
D
37 remained relatively constant for individual patients with increasing duration of disease or alterations in treatment status. The assay method may prove useful as an aid in predicting response to low-dose splenic irradiation (SI) in CLL.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1861541</pmid><doi>10.1016/0145-2126(91)90026-P</doi><tpages>13</tpages></addata></record> |
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source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | B-Lymphocytes - pathology B-Lymphocytes - radiation effects Biological and medical sciences cell death rate Cell Survival - radiation effects Chronic lymphocytic leukaemia colchicine ultrasensitivity Computer Simulation Hemopathies Humans interphase death intrinsic radiosensitivity Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy low-dose splenic radiotherapy lymphocytes Lymphocytes - pathology Lymphocytes - radiation effects Mathematical Computing Medical sciences Models, Biological Radiation Tolerance Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Time Factors |
title | Simplified quantitative estimation in vitro of lymphocyte radiosensitivity applied to patients with chronic lymphocytic leukaemia |
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