Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics
Ampicillin, benzylpenicillin, cefaclor and cefuroxime were exposed to strains of Branhamella catarrhalis and Haemophilus influenzae with and without ability to produce β-lactamase. The antibiotics were dissolved in phosphate buffer at pH 6, 7 and 8 and the mean enzyme activity was calculated from de...
Gespeichert in:
| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1983-09, Vol.12 (3), p.269-271 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 271 |
|---|---|
| container_issue | 3 |
| container_start_page | 269 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 12 |
| creator | Johnsson, Jan Brorson, John- Erik |
| description | Ampicillin, benzylpenicillin, cefaclor and cefuroxime were exposed to strains of Branhamella catarrhalis and Haemophilus influenzae with and without ability to produce β-lactamase. The antibiotics were dissolved in phosphate buffer at pH 6, 7 and 8 and the mean enzyme activity was calculated from decrease in peak heights by the HPLC technique. Cefuroxime was the most stable drug regardless of pH. For the other antibiotics, changes in pH influenced the results. In infectious processes factors like pH and pCO2 show some variation. This fact may influence the interaction between β-lactams and β-lactamases. |
| doi_str_mv | 10.1093/jac/12.3.269 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80713562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80713562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-39a6b42f201f1b067a270d276d523e5a98f0aca5319bfaaacb58a3ae3d42a5973</originalsourceid><addsrcrecordid>eNqFkT1vFDEQhi0ECkego0VyRcVebM_aXpcQhVxQBE2QEI016_VyDvtx2F4J0uYf8UP4Tfh0p1BSjTTvo2c0egl5ydmaMwNnt-jOuFjDWijziKx4rVglmOGPyYoBk5WuJTwlz1K6ZYwpqZoTcqIUkwB6Re6vpn5Y_OQ8nXv653c1oMs4YvIV3cW5W1yYvtGUI4Yp7ZF3Eactjn4YkDrMGOMWh5AoTh3doB_n3TYMS6Lh4L3DIp6o8zEXw78Dhc-hDXMOLj0nT3ockn9xnKfk8_uLm_NNdf3p8ur87XXlhGa5AoOqrUUvGO95y5TGsu6EVp0U4CWapmfoUAI3bY-IrpUNAnroaoHSaDglrw_e8tiPxadsx5Dc_pPJz0uyDdMcpBL_BTko03C-B98cQBfnlKLv7S6GEeMvy5ndl2NLOZYLC7aUU_BXR-_Sjr57gI9tlLw65CFl__MhxvjdKg1a2s2Xr_bm46XaGFXbD_AX-nqdbA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13698112</pqid></control><display><type>article</type><title>Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>Johnsson, Jan ; Brorson, John- Erik</creator><creatorcontrib>Johnsson, Jan ; Brorson, John- Erik</creatorcontrib><description>Ampicillin, benzylpenicillin, cefaclor and cefuroxime were exposed to strains of Branhamella catarrhalis and Haemophilus influenzae with and without ability to produce β-lactamase. The antibiotics were dissolved in phosphate buffer at pH 6, 7 and 8 and the mean enzyme activity was calculated from decrease in peak heights by the HPLC technique. Cefuroxime was the most stable drug regardless of pH. For the other antibiotics, changes in pH influenced the results. In infectious processes factors like pH and pCO2 show some variation. This fact may influence the interaction between β-lactams and β-lactamases.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/12.3.269</identifier><identifier>PMID: 6605337</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Anti-Bacterial Agents - metabolism ; beta-Lactamases - pharmacology ; beta-Lactams ; Branhamella catarrhalis ; Drug Stability ; Haemophilus influenzae ; Haemophilus influenzae - enzymology ; Hydrogen-Ion Concentration ; Hydrolysis ; Neisseriaceae - enzymology</subject><ispartof>Journal of antimicrobial chemotherapy, 1983-09, Vol.12 (3), p.269-271</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c270t-39a6b42f201f1b067a270d276d523e5a98f0aca5319bfaaacb58a3ae3d42a5973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6605337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnsson, Jan</creatorcontrib><creatorcontrib>Brorson, John- Erik</creatorcontrib><title>Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Ampicillin, benzylpenicillin, cefaclor and cefuroxime were exposed to strains of Branhamella catarrhalis and Haemophilus influenzae with and without ability to produce β-lactamase. The antibiotics were dissolved in phosphate buffer at pH 6, 7 and 8 and the mean enzyme activity was calculated from decrease in peak heights by the HPLC technique. Cefuroxime was the most stable drug regardless of pH. For the other antibiotics, changes in pH influenced the results. In infectious processes factors like pH and pCO2 show some variation. This fact may influence the interaction between β-lactams and β-lactamases.</description><subject>Anti-Bacterial Agents - metabolism</subject><subject>beta-Lactamases - pharmacology</subject><subject>beta-Lactams</subject><subject>Branhamella catarrhalis</subject><subject>Drug Stability</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae - enzymology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrolysis</subject><subject>Neisseriaceae - enzymology</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1vFDEQhi0ECkego0VyRcVebM_aXpcQhVxQBE2QEI016_VyDvtx2F4J0uYf8UP4Tfh0p1BSjTTvo2c0egl5ydmaMwNnt-jOuFjDWijziKx4rVglmOGPyYoBk5WuJTwlz1K6ZYwpqZoTcqIUkwB6Re6vpn5Y_OQ8nXv653c1oMs4YvIV3cW5W1yYvtGUI4Yp7ZF3Eactjn4YkDrMGOMWh5AoTh3doB_n3TYMS6Lh4L3DIp6o8zEXw78Dhc-hDXMOLj0nT3ockn9xnKfk8_uLm_NNdf3p8ur87XXlhGa5AoOqrUUvGO95y5TGsu6EVp0U4CWapmfoUAI3bY-IrpUNAnroaoHSaDglrw_e8tiPxadsx5Dc_pPJz0uyDdMcpBL_BTko03C-B98cQBfnlKLv7S6GEeMvy5ndl2NLOZYLC7aUU_BXR-_Sjr57gI9tlLw65CFl__MhxvjdKg1a2s2Xr_bm46XaGFXbD_AX-nqdbA</recordid><startdate>198309</startdate><enddate>198309</enddate><creator>Johnsson, Jan</creator><creator>Brorson, John- Erik</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198309</creationdate><title>Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics</title><author>Johnsson, Jan ; Brorson, John- Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-39a6b42f201f1b067a270d276d523e5a98f0aca5319bfaaacb58a3ae3d42a5973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Anti-Bacterial Agents - metabolism</topic><topic>beta-Lactamases - pharmacology</topic><topic>beta-Lactams</topic><topic>Branhamella catarrhalis</topic><topic>Drug Stability</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - enzymology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrolysis</topic><topic>Neisseriaceae - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnsson, Jan</creatorcontrib><creatorcontrib>Brorson, John- Erik</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnsson, Jan</au><au>Brorson, John- Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1983-09</date><risdate>1983</risdate><volume>12</volume><issue>3</issue><spage>269</spage><epage>271</epage><pages>269-271</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Ampicillin, benzylpenicillin, cefaclor and cefuroxime were exposed to strains of Branhamella catarrhalis and Haemophilus influenzae with and without ability to produce β-lactamase. The antibiotics were dissolved in phosphate buffer at pH 6, 7 and 8 and the mean enzyme activity was calculated from decrease in peak heights by the HPLC technique. Cefuroxime was the most stable drug regardless of pH. For the other antibiotics, changes in pH influenced the results. In infectious processes factors like pH and pCO2 show some variation. This fact may influence the interaction between β-lactams and β-lactamases.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>6605337</pmid><doi>10.1093/jac/12.3.269</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1983-09, Vol.12 (3), p.269-271 |
| issn | 0305-7453 1460-2091 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80713562 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Anti-Bacterial Agents - metabolism beta-Lactamases - pharmacology beta-Lactams Branhamella catarrhalis Drug Stability Haemophilus influenzae Haemophilus influenzae - enzymology Hydrogen-Ion Concentration Hydrolysis Neisseriaceae - enzymology |
| title | Influence of β-lactamase- producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain β-lactam antibiotics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T08%3A24%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20%CE%B2-lactamase-%20producing%20strains%20of%20Branhamella%20catarrhalis%20and%20Haemophilus%20influenzae%20on%20certain%20%CE%B2-lactam%20antibiotics&rft.jtitle=Journal%20of%20antimicrobial%20chemotherapy&rft.au=Johnsson,%20Jan&rft.date=1983-09&rft.volume=12&rft.issue=3&rft.spage=269&rft.epage=271&rft.pages=269-271&rft.issn=0305-7453&rft.eissn=1460-2091&rft_id=info:doi/10.1093/jac/12.3.269&rft_dat=%3Cproquest_cross%3E80713562%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13698112&rft_id=info:pmid/6605337&rfr_iscdi=true |