Histiocytic neoplasias: Immunohistochemical evaluation of their frequencies among malignant lymphoma and related conditions in Japan
Through histologic review of 1,766 cases with malignant lymphoma and related conditions, 35 cases (2%) were selected as probable histiocytic neoplasias. Proliferating cells in these cases had voluminous, granulated cytoplasm, and round to irregularly shaped nuclei often with bi‐ or multinucleated fo...
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| Veröffentlicht in: | Journal of surgical oncology 1991-08, Vol.47 (4), p.215-220 |
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| container_title | Journal of surgical oncology |
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| creator | Aozasa, Katsuyuki Ohsawa, Masahiko Saeki, Kazunori Horiuchi, Keisuke Tamai, Masamitsu Kohro, Takashi Kurata, Akihiko |
| description | Through histologic review of 1,766 cases with malignant lymphoma and related conditions, 35 cases (2%) were selected as probable histiocytic neoplasias. Proliferating cells in these cases had voluminous, granulated cytoplasm, and round to irregularly shaped nuclei often with bi‐ or multinucleated forms showing monomorphous or polymorphous proliferation accompanying small lymphocytes, plasma cells, and, less frequently, eosinophils. Cases showing proliferation of convoluted cells with numerous benign‐appearing histiocytes or large cells with clear cytoplasm were excluded under a diagnosis of T‐cell lymphoma. To evaluate the immunologic character of proliferating cells, immunohistochemistry using antibodies Mx‐Pan B, MB‐1, MT‐1, UCHL‐1, lysozyme, α1‐arantitrypsin, α1‐antichymotrypsin, S‐100α, S‐100α, Leu M1, epithelial membrane antigen, and Ki‐1 were carried out in 23 cases. Naphthol‐ASD‐chloroacetate reaction and toluidine blue stain were also performed. These procedures revealed that 12 cases (52%) were B‐cell type, three cases (13%) T‐cell type, six cases (26%) true histiocytic type, and two cases null type. Therefore, the frequency of cases with true histiocytic neoplasias among cases with malignant lymphoma and related conditions in Japan may be 0.5%. |
| doi_str_mv | 10.1002/jso.2930470403 |
| format | Article |
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Proliferating cells in these cases had voluminous, granulated cytoplasm, and round to irregularly shaped nuclei often with bi‐ or multinucleated forms showing monomorphous or polymorphous proliferation accompanying small lymphocytes, plasma cells, and, less frequently, eosinophils. Cases showing proliferation of convoluted cells with numerous benign‐appearing histiocytes or large cells with clear cytoplasm were excluded under a diagnosis of T‐cell lymphoma. To evaluate the immunologic character of proliferating cells, immunohistochemistry using antibodies Mx‐Pan B, MB‐1, MT‐1, UCHL‐1, lysozyme, α1‐arantitrypsin, α1‐antichymotrypsin, S‐100α, S‐100α, Leu M1, epithelial membrane antigen, and Ki‐1 were carried out in 23 cases. Naphthol‐ASD‐chloroacetate reaction and toluidine blue stain were also performed. These procedures revealed that 12 cases (52%) were B‐cell type, three cases (13%) T‐cell type, six cases (26%) true histiocytic type, and two cases null type. Therefore, the frequency of cases with true histiocytic neoplasias among cases with malignant lymphoma and related conditions in Japan may be 0.5%.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930470403</identifier><identifier>PMID: 1861492</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibodies, Monoclonal ; B cell ; Biological and medical sciences ; enzyme histochemistry ; Female ; Hematologic and hematopoietic diseases ; Histiocytes - ultrastructure ; Histiocytic Sarcoma - epidemiology ; Humans ; Immunoenzyme Techniques ; immunohistochemistry ; Japan ; Japan - epidemiology ; Lymphoma, Large B-Cell, Diffuse - chemistry ; Lymphoma, Large B-Cell, Diffuse - epidemiology ; Male ; Medical sciences ; Middle Aged ; T cell</subject><ispartof>Journal of surgical oncology, 1991-08, Vol.47 (4), p.215-220</ispartof><rights>Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4393-d97b2a0b9311b73af7eb420946cc0f615c06643a50b4de21581cec154cdf90703</citedby><cites>FETCH-LOGICAL-c4393-d97b2a0b9311b73af7eb420946cc0f615c06643a50b4de21581cec154cdf90703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.2930470403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.2930470403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5474944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1861492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aozasa, Katsuyuki</creatorcontrib><creatorcontrib>Ohsawa, Masahiko</creatorcontrib><creatorcontrib>Saeki, Kazunori</creatorcontrib><creatorcontrib>Horiuchi, Keisuke</creatorcontrib><creatorcontrib>Tamai, Masamitsu</creatorcontrib><creatorcontrib>Kohro, Takashi</creatorcontrib><creatorcontrib>Kurata, Akihiko</creatorcontrib><title>Histiocytic neoplasias: Immunohistochemical evaluation of their frequencies among malignant lymphoma and related conditions in Japan</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Through histologic review of 1,766 cases with malignant lymphoma and related conditions, 35 cases (2%) were selected as probable histiocytic neoplasias. Proliferating cells in these cases had voluminous, granulated cytoplasm, and round to irregularly shaped nuclei often with bi‐ or multinucleated forms showing monomorphous or polymorphous proliferation accompanying small lymphocytes, plasma cells, and, less frequently, eosinophils. Cases showing proliferation of convoluted cells with numerous benign‐appearing histiocytes or large cells with clear cytoplasm were excluded under a diagnosis of T‐cell lymphoma. To evaluate the immunologic character of proliferating cells, immunohistochemistry using antibodies Mx‐Pan B, MB‐1, MT‐1, UCHL‐1, lysozyme, α1‐arantitrypsin, α1‐antichymotrypsin, S‐100α, S‐100α, Leu M1, epithelial membrane antigen, and Ki‐1 were carried out in 23 cases. Naphthol‐ASD‐chloroacetate reaction and toluidine blue stain were also performed. These procedures revealed that 12 cases (52%) were B‐cell type, three cases (13%) T‐cell type, six cases (26%) true histiocytic type, and two cases null type. 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| subjects | Antibodies, Monoclonal B cell Biological and medical sciences enzyme histochemistry Female Hematologic and hematopoietic diseases Histiocytes - ultrastructure Histiocytic Sarcoma - epidemiology Humans Immunoenzyme Techniques immunohistochemistry Japan Japan - epidemiology Lymphoma, Large B-Cell, Diffuse - chemistry Lymphoma, Large B-Cell, Diffuse - epidemiology Male Medical sciences Middle Aged T cell |
| title | Histiocytic neoplasias: Immunohistochemical evaluation of their frequencies among malignant lymphoma and related conditions in Japan |
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