Immunomodulation by bromocriptine
Treatment of rats with the dopaminergic ergot alkaloid bromocriptine (BRC) inhibited the following immune reactions: contact sensitivity skin reaction to dinitrochlorobenzene (DNCB); antibody formation to sheep red blood cells and to bacterial lipopolysaccharide; adjuvant arthritis; and experimental...
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| Veröffentlicht in: | Immunopharmacology 1983-10, Vol.6 (3), p.231-243 |
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| container_title | Immunopharmacology |
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| creator | Nagy, Eva Berczi, I. Wren, Graham E. Asa, Sylvia L. Kovacs, K. |
| description | Treatment of rats with the dopaminergic ergot alkaloid bromocriptine (BRC) inhibited the following immune reactions: contact sensitivity skin reaction to dinitrochlorobenzene (DNCB); antibody formation to sheep red blood cells and to bacterial lipopolysaccharide; adjuvant arthritis; and experimental allergic encephalitis. Immunosuppressive doses of BRC (5 mg/kg) decreased the serum prolactin (PRL) levels from 84.8 ± 15.9 ng/ml to 4.9 ± 1.6 ng/ml. Further studies on DNCB contact sensitivity and on antibody formation revealed that the immunocompetence of BRC-suppressed animals could be restored by additional treatment with either prolactin (PRL) or growth hormone (GH). Treatment with adrenocorticotropic hormone antagonized the restoring effect of PRL and GH. These result suggest that BRC suppressed immunity by its inhibition of PRL, and possibly also by inhibition of GH secretion. |
| doi_str_mv | 10.1016/0162-3109(83)90023-1 |
| format | Article |
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Immunosuppressive doses of BRC (5 mg/kg) decreased the serum prolactin (PRL) levels from 84.8 ± 15.9 ng/ml to 4.9 ± 1.6 ng/ml. Further studies on DNCB contact sensitivity and on antibody formation revealed that the immunocompetence of BRC-suppressed animals could be restored by additional treatment with either prolactin (PRL) or growth hormone (GH). Treatment with adrenocorticotropic hormone antagonized the restoring effect of PRL and GH. These result suggest that BRC suppressed immunity by its inhibition of PRL, and possibly also by inhibition of GH secretion.</description><identifier>ISSN: 0162-3109</identifier><identifier>DOI: 10.1016/0162-3109(83)90023-1</identifier><identifier>PMID: 6355009</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>ACTH ; Animals ; Antibody Formation - drug effects ; Arthritis, Experimental - prevention & control ; Autoimmunity ; Bromocriptine ; Bromocriptine - pharmacology ; Cellular immunity ; Dermatitis, Contact - prevention & control ; Encephalitis - prevention & control ; Female ; Growth hormone ; Hormones - pharmacology ; Humoral immunity ; Hypersensitivity - prevention & control ; Immunity - drug effects ; Male ; Prolactin ; Rat ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Skin Transplantation</subject><ispartof>Immunopharmacology, 1983-10, Vol.6 (3), p.231-243</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-8ef419a0bdcaab10640dcd6e47c6807ff542af29e03213ffe037155ca3b10e623</citedby><cites>FETCH-LOGICAL-c388t-8ef419a0bdcaab10640dcd6e47c6807ff542af29e03213ffe037155ca3b10e623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6355009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagy, Eva</creatorcontrib><creatorcontrib>Berczi, I.</creatorcontrib><creatorcontrib>Wren, Graham E.</creatorcontrib><creatorcontrib>Asa, Sylvia L.</creatorcontrib><creatorcontrib>Kovacs, K.</creatorcontrib><title>Immunomodulation by bromocriptine</title><title>Immunopharmacology</title><addtitle>Immunopharmacology</addtitle><description>Treatment of rats with the dopaminergic ergot alkaloid bromocriptine (BRC) inhibited the following immune reactions: contact sensitivity skin reaction to dinitrochlorobenzene (DNCB); antibody formation to sheep red blood cells and to bacterial lipopolysaccharide; adjuvant arthritis; and experimental allergic encephalitis. Immunosuppressive doses of BRC (5 mg/kg) decreased the serum prolactin (PRL) levels from 84.8 ± 15.9 ng/ml to 4.9 ± 1.6 ng/ml. Further studies on DNCB contact sensitivity and on antibody formation revealed that the immunocompetence of BRC-suppressed animals could be restored by additional treatment with either prolactin (PRL) or growth hormone (GH). Treatment with adrenocorticotropic hormone antagonized the restoring effect of PRL and GH. These result suggest that BRC suppressed immunity by its inhibition of PRL, and possibly also by inhibition of GH secretion.</description><subject>ACTH</subject><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Arthritis, Experimental - prevention & control</subject><subject>Autoimmunity</subject><subject>Bromocriptine</subject><subject>Bromocriptine - pharmacology</subject><subject>Cellular immunity</subject><subject>Dermatitis, Contact - prevention & control</subject><subject>Encephalitis - prevention & control</subject><subject>Female</subject><subject>Growth hormone</subject><subject>Hormones - pharmacology</subject><subject>Humoral immunity</subject><subject>Hypersensitivity - prevention & control</subject><subject>Immunity - drug effects</subject><subject>Male</subject><subject>Prolactin</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Inbred Strains</subject><subject>Skin Transplantation</subject><issn>0162-3109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxXNQ1nX1P1BYL6KH6qRJ2vQiyOLHwoIXPYc0nUCkH2vSCvvfm9plj3oYBt689wZ-hFxQuKNAs_s4acIoFDeS3RYAKUvoEZkf5BNyGsInAPC8EDMyy5gQAMWcXK2bZmi7pquGWveua5flbln6KBjvtr1r8YwcW10HPN_vBfl4fnpfvSabt5f16nGTGCZln0i0nBYayspoXVLIOFSmypDnJpOQWyt4qm1aILCUMmvjzqkQRrNoxixlC3I99W599zVg6FXjgsG61i12Q1CxhFKQ8l8jjcWMCxqNfDIa34Xg0aqtd432O0VBjdjUyEeNfJRk6hebGmOX-_6hbLA6hPbM4v1humOk8e3Qq2ActgYr59H0qurc3w9-APRdfK4</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>Nagy, Eva</creator><creator>Berczi, I.</creator><creator>Wren, Graham E.</creator><creator>Asa, Sylvia L.</creator><creator>Kovacs, K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198310</creationdate><title>Immunomodulation by bromocriptine</title><author>Nagy, Eva ; Berczi, I. ; Wren, Graham E. ; Asa, Sylvia L. ; Kovacs, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-8ef419a0bdcaab10640dcd6e47c6807ff542af29e03213ffe037155ca3b10e623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>ACTH</topic><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Arthritis, Experimental - prevention & control</topic><topic>Autoimmunity</topic><topic>Bromocriptine</topic><topic>Bromocriptine - pharmacology</topic><topic>Cellular immunity</topic><topic>Dermatitis, Contact - prevention & control</topic><topic>Encephalitis - prevention & control</topic><topic>Female</topic><topic>Growth hormone</topic><topic>Hormones - pharmacology</topic><topic>Humoral immunity</topic><topic>Hypersensitivity - prevention & control</topic><topic>Immunity - drug effects</topic><topic>Male</topic><topic>Prolactin</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Rats, Inbred Strains</topic><topic>Skin Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagy, Eva</creatorcontrib><creatorcontrib>Berczi, I.</creatorcontrib><creatorcontrib>Wren, Graham E.</creatorcontrib><creatorcontrib>Asa, Sylvia L.</creatorcontrib><creatorcontrib>Kovacs, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagy, Eva</au><au>Berczi, I.</au><au>Wren, Graham E.</au><au>Asa, Sylvia L.</au><au>Kovacs, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulation by bromocriptine</atitle><jtitle>Immunopharmacology</jtitle><addtitle>Immunopharmacology</addtitle><date>1983-10</date><risdate>1983</risdate><volume>6</volume><issue>3</issue><spage>231</spage><epage>243</epage><pages>231-243</pages><issn>0162-3109</issn><abstract>Treatment of rats with the dopaminergic ergot alkaloid bromocriptine (BRC) inhibited the following immune reactions: contact sensitivity skin reaction to dinitrochlorobenzene (DNCB); antibody formation to sheep red blood cells and to bacterial lipopolysaccharide; adjuvant arthritis; and experimental allergic encephalitis. 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| subjects | ACTH Animals Antibody Formation - drug effects Arthritis, Experimental - prevention & control Autoimmunity Bromocriptine Bromocriptine - pharmacology Cellular immunity Dermatitis, Contact - prevention & control Encephalitis - prevention & control Female Growth hormone Hormones - pharmacology Humoral immunity Hypersensitivity - prevention & control Immunity - drug effects Male Prolactin Rat Rats Rats, Inbred Lew Rats, Inbred Strains Skin Transplantation |
| title | Immunomodulation by bromocriptine |
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