Pertussis toxin blocks melatonin-induced inhibition of forskolin-stimulated adenylate cyclase activity in the chick brain

The high-affinity guanine nucleotide-sensitive receptor sites for melatonin in the mammalian hypothalamus and pars tuberalis mediate inhibition of adenylate cyclase (AC) activity. Therefore, we have examined whether similar sites in the chick brain and retina also modulate AC activity. Melatonin did...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-07, Vol.178 (2), p.786-792
Hauptverfasser:	Niles, L.P., Ye, M., Pickering, D.S., Ying, S-W.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenylate cyclase Adenylate Cyclase Toxin Animals Biological and medical sciences Brain - enzymology Cell Membrane - enzymology Cell physiology Chickens Colforsin - antagonists & inhibitors Colforsin - pharmacology Fundamental and applied biological sciences. Psychology guanine nucleotide-binding protein Hormonal regulation Kinetics Melatonin - antagonists & inhibitors Melatonin - pharmacology Molecular and cellular biology Pertussis Toxin Retina - enzymology Synaptosomes - enzymology Virulence Factors, Bordetella - pharmacology
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