Clonorchis-associated cholangiocarcinoma: A report of two cases with unusual manifestations
Two cases of Clonorchis-associated cholangiocarcinoma are described along with their cholangio-graphic features to illustrate the spectrum of pathology ascribed to the injurious effects of the flukes on the bile duct epithelium. This includes adenomatous hyperplasia, extensive fibrosis, and carcinom...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1991-09, Vol.101 (3), p.831-839 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Ona, Fernando V. Dytoc, Joseph N.T. |
| description | Two cases of Clonorchis-associated cholangiocarcinoma are described along with their cholangio-graphic features to illustrate the spectrum of pathology ascribed to the injurious effects of the flukes on the bile duct epithelium. This includes adenomatous hyperplasia, extensive fibrosis, and carcinoma. The first case was also complicated by hepatic abscesses, left hepatic lobar atrophy, gastrobiliary and biliaro-cutaneous fistulae. The second case features an unusually dilated pancreatic duct containing pancreaticoliths that was found later to consist of hyperplastic bile duct epithelium, presumably carried by worm migration in the biliary tree. Liver sections from both patients showed typical features of hepatic clonorchiasis with the cancer. A knowledge of the wide spectrum of clinical presentation of clonorchiasis, particularly cholangiocarcinoma, might aid Western physicians in averting this serious sequela through prompt eradication of the helminthic infection and early recognition and treatment of its complications. |
| doi_str_mv | 10.1016/0016-5085(91)90546-W |
| format | Article |
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This includes adenomatous hyperplasia, extensive fibrosis, and carcinoma. The first case was also complicated by hepatic abscesses, left hepatic lobar atrophy, gastrobiliary and biliaro-cutaneous fistulae. The second case features an unusually dilated pancreatic duct containing pancreaticoliths that was found later to consist of hyperplastic bile duct epithelium, presumably carried by worm migration in the biliary tree. Liver sections from both patients showed typical features of hepatic clonorchiasis with the cancer. 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| ispartof | Gastroenterology (New York, N.Y. 1943), 1991-09, Vol.101 (3), p.831-839 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Adenoma, Bile Duct - parasitology Adult Animals Bile Duct Neoplasms - parasitology Bile Ducts, Intrahepatic - parasitology Biological and medical sciences Clonorchiasis - complications Clonorchis sinensis - isolation & purification Diseases caused by trematodes Helminthic diseases Humans Infectious diseases Liver Diseases, Parasitic - complications Male Medical sciences Middle Aged Miscellaneous Parasitic diseases |
| title | Clonorchis-associated cholangiocarcinoma: A report of two cases with unusual manifestations |
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