DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD
We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg−1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1991-07, Vol.67 (1), p.49-53 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | GIN, T. YAU, G. JONG, W. TAN, P. LEUNG, R.K.W. CHAN, K. |
| description | We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg−1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml min−1 kg−1, apparent volume of distribution at steady state 5.10 (2.46–6.61) litre kg−1 and mean residence time 161 (52.3–251) min; values for the postpartum group were 33.8 (21.5–47.2) ml min−1 kg−1, 5.17 (3.47–8.09) litre kg−1 and 163 (92.3–238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62–0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28–2.29%) compared with umbilical plasma (2.08–3.88%) (P |
| doi_str_mv | 10.1093/bja/67.1.49 |
| format | Article |
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The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml min−1 kg−1, apparent volume of distribution at steady state 5.10 (2.46–6.61) litre kg−1 and mean residence time 161 (52.3–251) min; values for the postpartum group were 33.8 (21.5–47.2) ml min−1 kg−1, 5.17 (3.47–8.09) litre kg−1 and 163 (92.3–238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62–0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28–2.29%) compared with umbilical plasma (2.08–3.88%) (P<0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range 0.05–0.11 μg ml−1 at 4h.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/67.1.49</identifier><identifier>PMID: 1859759</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anaesthesia: obstetric ; Anaesthetics ; Anesthesia, Obstetrical ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Blood Proteins - metabolism ; Cesarean Section ; Female ; Fetal Blood - metabolism ; Humans ; intravenous: propofol ; Maternal-Fetal Exchange ; Medical sciences ; Neuropharmacology ; Pharmacokinetics: propofol ; Pharmacology. Drug treatments ; Postpartum Period - blood ; Pregnancy ; Propofol - blood ; Propofol - pharmacokinetics ; Protein Binding ; puerperium ; Sterilization, Tubal</subject><ispartof>British journal of anaesthesia : BJA, 1991-07, Vol.67 (1), p.49-53</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-b82a12090e0cb15c5e0e260bbee685ac99440d9bac6cef9c0dd497d93e9739283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19781334$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1859759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIN, T.</creatorcontrib><creatorcontrib>YAU, G.</creatorcontrib><creatorcontrib>JONG, W.</creatorcontrib><creatorcontrib>TAN, P.</creatorcontrib><creatorcontrib>LEUNG, R.K.W.</creatorcontrib><creatorcontrib>CHAN, K.</creatorcontrib><title>DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg−1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml min−1 kg−1, apparent volume of distribution at steady state 5.10 (2.46–6.61) litre kg−1 and mean residence time 161 (52.3–251) min; values for the postpartum group were 33.8 (21.5–47.2) ml min−1 kg−1, 5.17 (3.47–8.09) litre kg−1 and 163 (92.3–238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62–0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28–2.29%) compared with umbilical plasma (2.08–3.88%) (P<0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range 0.05–0.11 μg ml−1 at 4h.</description><subject>Anaesthesia: obstetric</subject><subject>Anaesthetics</subject><subject>Anesthesia, Obstetrical</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Cesarean Section</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Humans</subject><subject>intravenous: propofol</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacokinetics: propofol</subject><subject>Pharmacology. Drug treatments</subject><subject>Postpartum Period - blood</subject><subject>Pregnancy</subject><subject>Propofol - blood</subject><subject>Propofol - pharmacokinetics</subject><subject>Protein Binding</subject><subject>puerperium</subject><subject>Sterilization, Tubal</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E2P0zAQBmALgZaycOKM5AtcULrjxI7jY9SmNKgkUZuVVnuxHGcqZenHrt0i-PcYUrEXTj68z8xYLyHvGUwZqOSmezA3qZyyKVcvyIRxyaJUSvaSTABARqBY_Jq88f4BgMlYiStyxTKhpFATUs7LTVNvyrasK1ovaLOum3pRr2je0llebPJ1kVd0U8z-grya07Ki7bKgYaht8nV7-402xbqs52_Jq63ZeXx3ea_J7aJoZ8toVX8pZ_kqsjwRp6jLYsNiUIBgOyasQMA4ha5DTDNhrFKcQ686Y1OLW2Wh77mSvUpQyUTFWXJNPo17H93x6Yz-pPeDt7jbmQMez15nIEGqDAL8PELrjt473OpHN-yN-6UZ6D_F6VCcTqVmmqugP1zWnrs99s92bCrkHy-58dbsts4c7OCfmZIZSxIeXDS6wZ_w57_cuO_hVCKFXt7da_41FS2r7vR98GL0GDr7MaDT3g54sNgPDu1J98fhv__9DZBzkFo</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>GIN, T.</creator><creator>YAU, G.</creator><creator>JONG, W.</creator><creator>TAN, P.</creator><creator>LEUNG, R.K.W.</creator><creator>CHAN, K.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD</title><author>GIN, T. ; YAU, G. ; JONG, W. ; TAN, P. ; LEUNG, R.K.W. ; CHAN, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-b82a12090e0cb15c5e0e260bbee685ac99440d9bac6cef9c0dd497d93e9739283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Anaesthesia: obstetric</topic><topic>Anaesthetics</topic><topic>Anesthesia, Obstetrical</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - metabolism</topic><topic>Cesarean Section</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Humans</topic><topic>intravenous: propofol</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacokinetics: propofol</topic><topic>Pharmacology. Drug treatments</topic><topic>Postpartum Period - blood</topic><topic>Pregnancy</topic><topic>Propofol - blood</topic><topic>Propofol - pharmacokinetics</topic><topic>Protein Binding</topic><topic>puerperium</topic><topic>Sterilization, Tubal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIN, T.</creatorcontrib><creatorcontrib>YAU, G.</creatorcontrib><creatorcontrib>JONG, W.</creatorcontrib><creatorcontrib>TAN, P.</creatorcontrib><creatorcontrib>LEUNG, R.K.W.</creatorcontrib><creatorcontrib>CHAN, K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIN, T.</au><au>YAU, G.</au><au>JONG, W.</au><au>TAN, P.</au><au>LEUNG, R.K.W.</au><au>CHAN, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>67</volume><issue>1</issue><spage>49</spage><epage>53</epage><pages>49-53</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg−1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml min−1 kg−1, apparent volume of distribution at steady state 5.10 (2.46–6.61) litre kg−1 and mean residence time 161 (52.3–251) min; values for the postpartum group were 33.8 (21.5–47.2) ml min−1 kg−1, 5.17 (3.47–8.09) litre kg−1 and 163 (92.3–238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62–0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28–2.29%) compared with umbilical plasma (2.08–3.88%) (P<0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range 0.05–0.11 μg ml−1 at 4h.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1859759</pmid><doi>10.1093/bja/67.1.49</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 1991-07, Vol.67 (1), p.49-53 |
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| subjects | Anaesthesia: obstetric Anaesthetics Anesthesia, Obstetrical Anesthetics. Neuromuscular blocking agents Biological and medical sciences Blood Proteins - metabolism Cesarean Section Female Fetal Blood - metabolism Humans intravenous: propofol Maternal-Fetal Exchange Medical sciences Neuropharmacology Pharmacokinetics: propofol Pharmacology. Drug treatments Postpartum Period - blood Pregnancy Propofol - blood Propofol - pharmacokinetics Protein Binding puerperium Sterilization, Tubal |
| title | DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD |
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