Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides
Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from perip...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1991-07, Vol.253 (5017), p.317-320 |
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| creator | Hall, William W. Liu, Chunren R. Schneewind, Olaf Takahashi, Hidehiro Kaplan, Mark H. Röupe, Gosta Vahlne, Anders |
| description | Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides. |
| doi_str_mv | 10.1126/science.1857968 |
| format | Article |
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Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1857968</identifier><identifier>PMID: 1857968</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>AIDS/HIV ; Base Sequence ; Biological and medical sciences ; Blood ; Causes of ; Cell lines ; Chromosome Deletion ; DNA ; DNA probes ; DNA, Neoplasm - genetics ; DNA, Neoplasm - isolation & purification ; DNA, Viral - genetics ; DNA, Viral - isolation & purification ; Genes, Viral ; HTLV-I infections ; Human T lymphotropic virus 1 ; Human T-lymphotropic virus 1 - genetics ; Human T-lymphotropic virus 1 - isolation & purification ; Human viral diseases ; Humans ; Infectious diseases ; Lesions ; Leukemia ; Lymphocytes ; Lymphocytes - microbiology ; Medical research ; Medical sciences ; Molecular Sequence Data ; Mycosis fungoides ; Mycosis Fungoides - blood ; Mycosis Fungoides - microbiology ; Oligonucleotide Probes ; Polymerase Chain Reaction ; Proviruses ; Proviruses - genetics ; Proviruses - isolation & purification ; Restriction Mapping ; Sequence Homology, Nucleic Acid ; Skin - microbiology ; Skin Neoplasms - blood ; Skin Neoplasms - microbiology ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1991-07, Vol.253 (5017), p.317-320</ispartof><rights>Copyright 1991 American Association for the Advancement of Science</rights><rights>1992 INIST-CNRS</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 19, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c737t-54838f50df0a2d945bed0c46113ee296b8b5ec37adc8553cd211836c281cd06f3</citedby><cites>FETCH-LOGICAL-c737t-54838f50df0a2d945bed0c46113ee296b8b5ec37adc8553cd211836c281cd06f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2879079$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2879079$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2883,2884,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5070455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1857968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, William W.</creatorcontrib><creatorcontrib>Liu, Chunren R.</creatorcontrib><creatorcontrib>Schneewind, Olaf</creatorcontrib><creatorcontrib>Takahashi, Hidehiro</creatorcontrib><creatorcontrib>Kaplan, Mark H.</creatorcontrib><creatorcontrib>Röupe, Gosta</creatorcontrib><creatorcontrib>Vahlne, Anders</creatorcontrib><title>Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.</description><subject>AIDS/HIV</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Causes of</subject><subject>Cell lines</subject><subject>Chromosome Deletion</subject><subject>DNA</subject><subject>DNA probes</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>DNA, Viral - genetics</subject><subject>DNA, Viral - isolation & purification</subject><subject>Genes, Viral</subject><subject>HTLV-I infections</subject><subject>Human T lymphotropic virus 1</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Leukemia</subject><subject>Lymphocytes</subject><subject>Lymphocytes - microbiology</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - blood</subject><subject>Mycosis Fungoides - microbiology</subject><subject>Oligonucleotide Probes</subject><subject>Polymerase Chain Reaction</subject><subject>Proviruses</subject><subject>Proviruses - genetics</subject><subject>Proviruses - isolation & purification</subject><subject>Restriction Mapping</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Skin - microbiology</subject><subject>Skin Neoplasms - blood</subject><subject>Skin Neoplasms - microbiology</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the 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HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides</title><author>Hall, William W. ; Liu, Chunren R. ; Schneewind, Olaf ; Takahashi, Hidehiro ; Kaplan, Mark H. ; Röupe, Gosta ; Vahlne, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c737t-54838f50df0a2d945bed0c46113ee296b8b5ec37adc8553cd211836c281cd06f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>AIDS/HIV</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Causes of</topic><topic>Cell lines</topic><topic>Chromosome Deletion</topic><topic>DNA</topic><topic>DNA probes</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>DNA, Viral - genetics</topic><topic>DNA, Viral - isolation & purification</topic><topic>Genes, Viral</topic><topic>HTLV-I infections</topic><topic>Human T lymphotropic virus 1</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Human T-lymphotropic virus 1 - isolation & purification</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Leukemia</topic><topic>Lymphocytes</topic><topic>Lymphocytes - microbiology</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - blood</topic><topic>Mycosis Fungoides - microbiology</topic><topic>Oligonucleotide Probes</topic><topic>Polymerase Chain Reaction</topic><topic>Proviruses</topic><topic>Proviruses - genetics</topic><topic>Proviruses - isolation & purification</topic><topic>Restriction Mapping</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Skin - microbiology</topic><topic>Skin Neoplasms - blood</topic><topic>Skin Neoplasms - microbiology</topic><topic>Viral diseases</topic><topic>Viral 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Science)</jtitle><addtitle>Science</addtitle><date>1991-07-19</date><risdate>1991</risdate><volume>253</volume><issue>5017</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>1857968</pmid><doi>10.1126/science.1857968</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1991-07, Vol.253 (5017), p.317-320 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80707006 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | AIDS/HIV Base Sequence Biological and medical sciences Blood Causes of Cell lines Chromosome Deletion DNA DNA probes DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification DNA, Viral - genetics DNA, Viral - isolation & purification Genes, Viral HTLV-I infections Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - isolation & purification Human viral diseases Humans Infectious diseases Lesions Leukemia Lymphocytes Lymphocytes - microbiology Medical research Medical sciences Molecular Sequence Data Mycosis fungoides Mycosis Fungoides - blood Mycosis Fungoides - microbiology Oligonucleotide Probes Polymerase Chain Reaction Proviruses Proviruses - genetics Proviruses - isolation & purification Restriction Mapping Sequence Homology, Nucleic Acid Skin - microbiology Skin Neoplasms - blood Skin Neoplasms - microbiology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Viruses |
| title | Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A53%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deleted%20HTLV-I%20Provirus%20in%20Blood%20and%20Cutaneous%20Lesions%20of%20Patients%20with%20Mycosis%20Fungoides&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Hall,%20William%20W.&rft.date=1991-07-19&rft.volume=253&rft.issue=5017&rft.spage=317&rft.epage=320&rft.pages=317-320&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1857968&rft_dat=%3Cgale_proqu%3EA11145360%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213573363&rft_id=info:pmid/1857968&rft_galeid=A11145360&rft_jstor_id=2879079&rfr_iscdi=true |