On the pharmacokinetics of pengitoxin and its cardioactive derivative 16-acetyl-gitoxin

The pharmacokinetics of pengitoxin has been studied in 28 healthy subjects after intravenous and oral administration. The mean plasma concentration 24 h after 0.5 mg i.v. was 5.2 ng X ml-1. Following an open two-compartment model a mean elimination half-life of 60.5 h (24.9 to 103.5 h) and a mean vo...

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Veröffentlicht in:	European journal of clinical pharmacology 1983-01, Vol.25 (3), p.369-373
Hauptverfasser:	HAUSTEIN, K.-O, ALKEN, R. G, LACH, H. J, BECKER, U, RIETBROCK, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyldigoxins - metabolism Adult Biological and medical sciences Cardiotonic agents Cardiovascular system Digoxin - analogs & derivatives Female Humans Kinetics Male Medical sciences Pharmacology. Drug treatments Radioimmunoassay
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