Paternal inheritance of mitochondrial DNA in mice
For nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals. Using the polymerase chain reaction, paternally inherited mtDNA molecules have now been...
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| Veröffentlicht in: | Nature (London) 1991-07, Vol.352 (6332), p.255-257 |
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| creator | GYLLENSTEN, U WHARTON, D JOSEFSSON, A WILSON, A. C |
| description | For nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals. Using the polymerase chain reaction, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10(-4), relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission. |
| doi_str_mv | 10.1038/352255a0 |
| format | Article |
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C</creator><creatorcontrib>GYLLENSTEN, U ; WHARTON, D ; JOSEFSSON, A ; WILSON, A. C</creatorcontrib><description>For nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals. Using the polymerase chain reaction, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10(-4), relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/352255a0</identifier><identifier>PMID: 1857422</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Crosses, Genetic ; Deoxyribonucleic acid ; DNA ; DNA, Mitochondrial - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Genetics ; Hybrids ; Male ; Mice ; Mice, Inbred C57BL - genetics ; Mitochondrial DNA ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Muridae - genetics ; Oligonucleotide Probes ; Polymerase Chain Reaction - methods ; Sequence Homology, Nucleic Acid</subject><ispartof>Nature (London), 1991-07, Vol.352 (6332), p.255-257</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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C</creatorcontrib><title>Paternal inheritance of mitochondrial DNA in mice</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>For nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals. Using the polymerase chain reaction, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10(-4), relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Crosses, Genetic</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Genetics</subject><subject>Hybrids</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - genetics</subject><subject>Mitochondrial DNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Muridae - genetics</subject><subject>Oligonucleotide Probes</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0U1LAzEQBuAgSq1V8A8IRUS9rE6SyWb2WOonFPWg5yXNZumW7W5Ntgf_vSmtCh70FJj3YWDyMnbM4YqDpGuphFDKwA7rc9RpginpXdYHEJQAyXSfHYQwBwDFNfZYj5PSKESf8RfTOd-Yelg1M-erzjTWDdtyuKi61s7apvBVDG-eRhHEoXWHbK80dXBH23fA3u5uX8cPyeT5_nE8miQWU9kl6KgQRguLMJVacAQLJjMpIp-iM1OytjRlDFInSAgslHaUFpoySdpJIQfsfLN36dv3lQtdvqiCdXVtGteuQk6gIZ4AEV78CTVKmRES_ruSq4xIcB7h6S84b1frXwq5AESpFa3R5QZZ34bgXZkvfbUw_iPnkK9byb9aifRku281XbjiB25qiPnZNjfBmrr0sYUqfDMVD80wk5-GHI-N</recordid><startdate>19910718</startdate><enddate>19910718</enddate><creator>GYLLENSTEN, U</creator><creator>WHARTON, D</creator><creator>JOSEFSSON, A</creator><creator>WILSON, A. 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| ispartof | Nature (London), 1991-07, Vol.352 (6332), p.255-257 |
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| subjects | Animals Base Sequence Biological and medical sciences Crosses, Genetic Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Female Fundamental and applied biological sciences. Psychology Genes. Genome Genetics Hybrids Male Mice Mice, Inbred C57BL - genetics Mitochondrial DNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Muridae - genetics Oligonucleotide Probes Polymerase Chain Reaction - methods Sequence Homology, Nucleic Acid |
| title | Paternal inheritance of mitochondrial DNA in mice |
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