Local DNA topology and gene expression: the case of the leu‐500 promoter
Summary Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important rote in gene regulation. The twin super ‐coiled‐domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu‐500 pro...
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| Veröffentlicht in: | Molecular microbiology 1991-04, Vol.5 (4), p.779-783 |
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| container_title | Molecular microbiology |
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| creator | Lilley, D. M. J. Higgins, C. F. |
| description | Summary
Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important rote in gene regulation. The twin super ‐coiled‐domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu‐500 promoter has presented a long‐standing problem to the understanding of the control of promoter function by DNA supercoiling. This promoter is activated by mutations in the gene encoding topoisomerase I, but is apparently unaffected by mutations in the genes encoding DNA gyrase. We propose a model to explain the anomalous regulation of this promoter, based on the twin super‐coiled‐domain model. This allows us to account for the unusual properties of the leu‐500 promoter, and confirms the biological importance of the twin super‐coiled‐domain model. We suggest that such topological coupling between promoters may be general, leading to co‐operativity and anti‐co‐operativity between divergent promoter pairs. |
| doi_str_mv | 10.1111/j.1365-2958.1991.tb00749.x |
| format | Article |
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Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important rote in gene regulation. The twin super ‐coiled‐domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu‐500 promoter has presented a long‐standing problem to the understanding of the control of promoter function by DNA supercoiling. This promoter is activated by mutations in the gene encoding topoisomerase I, but is apparently unaffected by mutations in the genes encoding DNA gyrase. We propose a model to explain the anomalous regulation of this promoter, based on the twin super‐coiled‐domain model. This allows us to account for the unusual properties of the leu‐500 promoter, and confirms the biological importance of the twin super‐coiled‐domain model. We suggest that such topological coupling between promoters may be general, leading to co‐operativity and anti‐co‐operativity between divergent promoter pairs.</description><identifier>ISSN: 0950-382X</identifier><identifier>EISSN: 1365-2958</identifier><identifier>DOI: 10.1111/j.1365-2958.1991.tb00749.x</identifier><identifier>PMID: 1857204</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Bacteriology ; Biological and medical sciences ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; DNA, Superhelical - chemistry ; DNA, Superhelical - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Genetics ; Microbiology ; Models, Genetic ; Mutation ; Nucleic Acid Conformation ; Promoter Regions, Genetic ; Salmonella typhimurium - genetics ; Transcription, Genetic</subject><ispartof>Molecular microbiology, 1991-04, Vol.5 (4), p.779-783</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4309-28a9b966dfeb72e8191cfac24dada20f9a059d25f8e00ac07be1c201eb6eb1dc3</citedby><cites>FETCH-LOGICAL-c4309-28a9b966dfeb72e8191cfac24dada20f9a059d25f8e00ac07be1c201eb6eb1dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2958.1991.tb00749.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2958.1991.tb00749.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19728903$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1857204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lilley, D. M. J.</creatorcontrib><creatorcontrib>Higgins, C. F.</creatorcontrib><title>Local DNA topology and gene expression: the case of the leu‐500 promoter</title><title>Molecular microbiology</title><addtitle>Mol Microbiol</addtitle><description>Summary
Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important rote in gene regulation. The twin super ‐coiled‐domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu‐500 promoter has presented a long‐standing problem to the understanding of the control of promoter function by DNA supercoiling. This promoter is activated by mutations in the gene encoding topoisomerase I, but is apparently unaffected by mutations in the genes encoding DNA gyrase. We propose a model to explain the anomalous regulation of this promoter, based on the twin super‐coiled‐domain model. This allows us to account for the unusual properties of the leu‐500 promoter, and confirms the biological importance of the twin super‐coiled‐domain model. We suggest that such topological coupling between promoters may be general, leading to co‐operativity and anti‐co‐operativity between divergent promoter pairs.</description><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Superhelical - chemistry</subject><subject>DNA, Superhelical - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genetics</subject><subject>Microbiology</subject><subject>Models, Genetic</subject><subject>Mutation</subject><subject>Nucleic Acid Conformation</subject><subject>Promoter Regions, Genetic</subject><subject>Salmonella typhimurium - genetics</subject><subject>Transcription, Genetic</subject><issn>0950-382X</issn><issn>1365-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtOwzAQhi0EKuVxBCQLCXYJYyeOYxZIiGdRgQ1I7CzHmUCqNC5xKtodR-CMnISUVrBEzMYj_d94Rh8h-wxC1tXRKGRRIgKuRBoypVjYZgAyVuFsjfR_onXSByUgiFL-tEm2vB8BsAiSqEd6LBWSQ9wnN0NnTUXP705p6yaucs9zauqcPmONFGeTBr0vXX1M2xek1nikrvjuK5x-vn8IADpp3Ni12OyQjcJUHndX7zZ5vLx4OLsOhvdXg7PTYWDjCFTAU6MylSR5gZnkmDLFbGEsj3OTGw6FMiBUzkWRIoCxIDNklgPDLMGM5TbaJofLf7vFr1P0rR6X3mJVmRrd1OsUJERKwZ8gEyoWiZQdeLwEbeO8b7DQk6Ycm2auGeiFcT3SC616oVUvjOuVcT3rhvdWW6bZGPPf0aXiLj9Y5cZ3qovG1Lb0v5iSPO2O7biTJfdWVjj_xwX69nYgpYq-AKXSnhI</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Lilley, D. 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F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4309-28a9b966dfeb72e8191cfac24dada20f9a059d25f8e00ac07be1c201eb6eb1dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Superhelical - chemistry</topic><topic>DNA, Superhelical - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Genetics</topic><topic>Microbiology</topic><topic>Models, Genetic</topic><topic>Mutation</topic><topic>Nucleic Acid Conformation</topic><topic>Promoter Regions, Genetic</topic><topic>Salmonella typhimurium - genetics</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lilley, D. M. J.</creatorcontrib><creatorcontrib>Higgins, C. 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F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local DNA topology and gene expression: the case of the leu‐500 promoter</atitle><jtitle>Molecular microbiology</jtitle><addtitle>Mol Microbiol</addtitle><date>1991-04</date><risdate>1991</risdate><volume>5</volume><issue>4</issue><spage>779</spage><epage>783</epage><pages>779-783</pages><issn>0950-382X</issn><eissn>1365-2958</eissn><abstract>Summary
Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important rote in gene regulation. The twin super ‐coiled‐domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu‐500 promoter has presented a long‐standing problem to the understanding of the control of promoter function by DNA supercoiling. This promoter is activated by mutations in the gene encoding topoisomerase I, but is apparently unaffected by mutations in the genes encoding DNA gyrase. We propose a model to explain the anomalous regulation of this promoter, based on the twin super‐coiled‐domain model. This allows us to account for the unusual properties of the leu‐500 promoter, and confirms the biological importance of the twin super‐coiled‐domain model. We suggest that such topological coupling between promoters may be general, leading to co‐operativity and anti‐co‐operativity between divergent promoter pairs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1857204</pmid><doi>10.1111/j.1365-2958.1991.tb00749.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0950-382X |
| ispartof | Molecular microbiology, 1991-04, Vol.5 (4), p.779-783 |
| issn | 0950-382X 1365-2958 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Bacteriology Biological and medical sciences DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Superhelical - chemistry DNA, Superhelical - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genetics Microbiology Models, Genetic Mutation Nucleic Acid Conformation Promoter Regions, Genetic Salmonella typhimurium - genetics Transcription, Genetic |
| title | Local DNA topology and gene expression: the case of the leu‐500 promoter |
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