Inhibition of the growth of Plasmodium falciparum and Plasmodium berghei by the DNA polymerase inhibitor HPMPA

The acyclic adenosine analogue ( S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [HPMPA] belongs to a class of nucleoside analogues originally described as having potent activity against a broad spectrum of DNA viruses. We examined the effects of this class of drugs on the growth of cultured Plasm...

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Veröffentlicht in:	Molecular and biochemical parasitology 1991-07, Vol.47 (1), p.43-50
Hauptverfasser:	de Vries, Erik, Stam, Jeanette G., Franssen, Frits F.J., Nieuwenhuijs, Hans, Chavalitshewinkoon, Porntip, de Clercq, Erik, Prosper Overdulve, J., van der Vliet, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclic nucleoside Adenine - analogs & derivatives Adenine - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Binding, Competitive Biological and medical sciences Cell Line Deoxyadenine Nucleotides - pharmacology DNA polymerase inhibitor Erythrocytes - drug effects Erythrocytes - parasitology HPMPA Humans Malaria Malaria - drug therapy Medical sciences Mice Mice, Inbred BALB C Nucleic Acid Synthesis Inhibitors Organophosphonates Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments Plasmodium berghei Plasmodium berghei - drug effects Plasmodium berghei - enzymology Plasmodium berghei - growth & development Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - growth & development Tropical medicine
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