PGI2-induced activation and sensitization of articular mechanonociceptors

The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulati...

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Veröffentlicht in:	Neuroscience letters 1991-03, Vol.124 (1), p.5-8
Hauptverfasser:	BIRRELL, G. J, MCQUEEN, D. S, IGGO, A, COLEMAN, R. A, GRUBB, B. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dinoprostone - pharmacology Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Fundamental and applied biological sciences. Psychology Male Mechanoreceptors - drug effects Neural Conduction - drug effects Nociceptors - drug effects Rats Rats, Inbred Strains Sensory Thresholds - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tarsus, Animal - drug effects Vertebrates: nervous system and sense organs
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