PGI2-induced activation and sensitization of articular mechanonociceptors
The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulati...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 1991-03, Vol.124 (1), p.5-8 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8 |
|---|---|
| container_issue | 1 |
| container_start_page | 5 |
| container_title | Neuroscience letters |
| container_volume | 124 |
| creator | BIRRELL, G. J MCQUEEN, D. S IGGO, A COLEMAN, R. A GRUBB, B. D |
| description | The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulation and excitation of the majority of mechanonociceptors, whereas PGE2 (0.03-3 micrograms) had only weak effects on a small number of nociceptive units. These results suggest the existence of specific PGI2 sensitive receptors (IP receptors) on rat sensory afferent nerves, and support the hypothesis that in the rat endogenous PGI2 plays an important role in the lowering of nociceptive thresholds in inflamed joints. |
| doi_str_mv | 10.1016/0304-3940(91)90809-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80703175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80703175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-dc7636d839f7570cbb383cee7d41cc6d47714bc5fdcc0791f602a1d3aff10b833</originalsourceid><addsrcrecordid>eNpFkE1LAzEURYMotVb_gcJsFF2MvkxmJslSitZCQRe6DpmXBCPzUZMZQX-9U1vs6sG7597FIeScwi0FWt4BgzxlModrSW8kCJCpOCBTKniWcsmzQzL9R47JSYwfAFDQIp-QCRUFL3I2JcuXxTJLfWsGtCbR2Psv3fuuTXRrkmjb6Hv_s_10LtGh9zjUOiSNxXfddm2HHu2670I8JUdO19Ge7e6MvD0-vM6f0tXzYjm_X6XIWNanBnnJSiOYdLzggFXFBENruckpYmlyzmleYeEMInBJXQmZpoZp5yhUgrEZudrurkP3OdjYq8ZHtHWtW9sNUQngwCgvRjDfghi6GIN1ah18o8O3oqA2BtVGj9roUZKqP4NKjLWL3f5QNdbsS1tlY365y3VEXbugW_Rxj8mR4yVlv7hBeZE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80703175</pqid></control><display><type>article</type><title>PGI2-induced activation and sensitization of articular mechanonociceptors</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>BIRRELL, G. J ; MCQUEEN, D. S ; IGGO, A ; COLEMAN, R. A ; GRUBB, B. D</creator><creatorcontrib>BIRRELL, G. J ; MCQUEEN, D. S ; IGGO, A ; COLEMAN, R. A ; GRUBB, B. D</creatorcontrib><description>The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulation and excitation of the majority of mechanonociceptors, whereas PGE2 (0.03-3 micrograms) had only weak effects on a small number of nociceptive units. These results suggest the existence of specific PGI2 sensitive receptors (IP receptors) on rat sensory afferent nerves, and support the hypothesis that in the rat endogenous PGI2 plays an important role in the lowering of nociceptive thresholds in inflamed joints.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(91)90809-8</identifier><identifier>PMID: 1857543</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Dinoprostone - pharmacology ; Epoprostenol - analogs & derivatives ; Epoprostenol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Male ; Mechanoreceptors - drug effects ; Neural Conduction - drug effects ; Nociceptors - drug effects ; Rats ; Rats, Inbred Strains ; Sensory Thresholds - drug effects ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Tarsus, Animal - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1991-03, Vol.124 (1), p.5-8</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-dc7636d839f7570cbb383cee7d41cc6d47714bc5fdcc0791f602a1d3aff10b833</citedby><cites>FETCH-LOGICAL-c332t-dc7636d839f7570cbb383cee7d41cc6d47714bc5fdcc0791f602a1d3aff10b833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19857761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1857543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BIRRELL, G. J</creatorcontrib><creatorcontrib>MCQUEEN, D. S</creatorcontrib><creatorcontrib>IGGO, A</creatorcontrib><creatorcontrib>COLEMAN, R. A</creatorcontrib><creatorcontrib>GRUBB, B. D</creatorcontrib><title>PGI2-induced activation and sensitization of articular mechanonociceptors</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulation and excitation of the majority of mechanonociceptors, whereas PGE2 (0.03-3 micrograms) had only weak effects on a small number of nociceptive units. These results suggest the existence of specific PGI2 sensitive receptors (IP receptors) on rat sensory afferent nerves, and support the hypothesis that in the rat endogenous PGI2 plays an important role in the lowering of nociceptive thresholds in inflamed joints.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dinoprostone - pharmacology</subject><subject>Epoprostenol - analogs & derivatives</subject><subject>Epoprostenol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mechanoreceptors - drug effects</subject><subject>Neural Conduction - drug effects</subject><subject>Nociceptors - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sensory Thresholds - drug effects</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Tarsus, Animal - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEURYMotVb_gcJsFF2MvkxmJslSitZCQRe6DpmXBCPzUZMZQX-9U1vs6sG7597FIeScwi0FWt4BgzxlModrSW8kCJCpOCBTKniWcsmzQzL9R47JSYwfAFDQIp-QCRUFL3I2JcuXxTJLfWsGtCbR2Psv3fuuTXRrkmjb6Hv_s_10LtGh9zjUOiSNxXfddm2HHu2670I8JUdO19Ge7e6MvD0-vM6f0tXzYjm_X6XIWNanBnnJSiOYdLzggFXFBENruckpYmlyzmleYeEMInBJXQmZpoZp5yhUgrEZudrurkP3OdjYq8ZHtHWtW9sNUQngwCgvRjDfghi6GIN1ah18o8O3oqA2BtVGj9roUZKqP4NKjLWL3f5QNdbsS1tlY365y3VEXbugW_Rxj8mR4yVlv7hBeZE</recordid><startdate>19910311</startdate><enddate>19910311</enddate><creator>BIRRELL, G. J</creator><creator>MCQUEEN, D. S</creator><creator>IGGO, A</creator><creator>COLEMAN, R. A</creator><creator>GRUBB, B. D</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910311</creationdate><title>PGI2-induced activation and sensitization of articular mechanonociceptors</title><author>BIRRELL, G. J ; MCQUEEN, D. S ; IGGO, A ; COLEMAN, R. A ; GRUBB, B. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-dc7636d839f7570cbb383cee7d41cc6d47714bc5fdcc0791f602a1d3aff10b833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dinoprostone - pharmacology</topic><topic>Epoprostenol - analogs & derivatives</topic><topic>Epoprostenol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mechanoreceptors - drug effects</topic><topic>Neural Conduction - drug effects</topic><topic>Nociceptors - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sensory Thresholds - drug effects</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Tarsus, Animal - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BIRRELL, G. J</creatorcontrib><creatorcontrib>MCQUEEN, D. S</creatorcontrib><creatorcontrib>IGGO, A</creatorcontrib><creatorcontrib>COLEMAN, R. A</creatorcontrib><creatorcontrib>GRUBB, B. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BIRRELL, G. J</au><au>MCQUEEN, D. S</au><au>IGGO, A</au><au>COLEMAN, R. A</au><au>GRUBB, B. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PGI2-induced activation and sensitization of articular mechanonociceptors</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-03-11</date><risdate>1991</risdate><volume>124</volume><issue>1</issue><spage>5</spage><epage>8</epage><pages>5-8</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The effects of PGE2 PGI2 and the stable PGI2 analogue cicaprost on the afferent discharge of ankle joint mechanonociceptors were studied in the anaesthetized rat. Close-arterial injection of PGI2 (0.01-0.1 micrograms) or cicaprost (0.05-5 micrograms) caused both sensitization to mechanical stimulation and excitation of the majority of mechanonociceptors, whereas PGE2 (0.03-3 micrograms) had only weak effects on a small number of nociceptive units. These results suggest the existence of specific PGI2 sensitive receptors (IP receptors) on rat sensory afferent nerves, and support the hypothesis that in the rat endogenous PGI2 plays an important role in the lowering of nociceptive thresholds in inflamed joints.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>1857543</pmid><doi>10.1016/0304-3940(91)90809-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1991-03, Vol.124 (1), p.5-8 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80703175 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Dinoprostone - pharmacology Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Fundamental and applied biological sciences. Psychology Male Mechanoreceptors - drug effects Neural Conduction - drug effects Nociceptors - drug effects Rats Rats, Inbred Strains Sensory Thresholds - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tarsus, Animal - drug effects Vertebrates: nervous system and sense organs |
| title | PGI2-induced activation and sensitization of articular mechanonociceptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A13%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PGI2-induced%20activation%20and%20sensitization%20of%20articular%20mechanonociceptors&rft.jtitle=Neuroscience%20letters&rft.au=BIRRELL,%20G.%20J&rft.date=1991-03-11&rft.volume=124&rft.issue=1&rft.spage=5&rft.epage=8&rft.pages=5-8&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/0304-3940(91)90809-8&rft_dat=%3Cproquest_cross%3E80703175%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80703175&rft_id=info:pmid/1857543&rfr_iscdi=true |