Anaplastic carcinoma of the thyroid with osteoclast‐like giant cells
An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre‐existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicula...
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| Veröffentlicht in: | Cancer 1983-12, Vol.52 (11), p.2122-2128 |
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| container_end_page | 2128 |
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| container_issue | 11 |
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| container_title | Cancer |
| container_volume | 52 |
| creator | Esmaili, Jaleh H. Hafez, Gholam Reza Warner, Thomas F. C. S. |
| description | An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre‐existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle‐shaped cells and giant cells were accompanied by numerous osteoclast‐like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm. Cancer 52:2122‐2128, 1983. |
| doi_str_mv | 10.1002/1097-0142(19831201)52:11<2122::AID-CNCR2820521125>3.0.CO;2-3 |
| format | Article |
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Cancer 52:2122‐2128, 1983.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19831201)52:11<2122::AID-CNCR2820521125>3.0.CO;2-3</identifier><identifier>PMID: 6354425</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma - pathology ; Carcinoma - ultrastructure ; Endocrinopathies ; Female ; Giant Cell Tumors - pathology ; Giant Cell Tumors - ultrastructure ; Humans ; Malignant tumors ; Medical sciences ; Microscopy, Electron ; Osteoclasts - pathology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - ultrastructure ; Thyroid. 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C. S.</creatorcontrib><title>Anaplastic carcinoma of the thyroid with osteoclast‐like giant cells</title><title>Cancer</title><addtitle>Cancer</addtitle><description>An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre‐existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle‐shaped cells and giant cells were accompanied by numerous osteoclast‐like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm. Cancer 52:2122‐2128, 1983.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - ultrastructure</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Giant Cell Tumors - pathology</subject><subject>Giant Cell Tumors - ultrastructure</subject><subject>Humans</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Osteoclasts - pathology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - ultrastructure</subject><subject>Thyroid. 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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic carcinoma of the thyroid with osteoclast‐like giant cells</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1983-12-01</date><risdate>1983</risdate><volume>52</volume><issue>11</issue><spage>2122</spage><epage>2128</epage><pages>2122-2128</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre‐existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle‐shaped cells and giant cells were accompanied by numerous osteoclast‐like multinucleated giant cells. 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| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1983-12, Vol.52 (11), p.2122-2128 |
| issn | 0008-543X 1097-0142 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Carcinoma - pathology Carcinoma - ultrastructure Endocrinopathies Female Giant Cell Tumors - pathology Giant Cell Tumors - ultrastructure Humans Malignant tumors Medical sciences Microscopy, Electron Osteoclasts - pathology Thyroid Neoplasms - pathology Thyroid Neoplasms - ultrastructure Thyroid. Thyroid axis (diseases) |
| title | Anaplastic carcinoma of the thyroid with osteoclast‐like giant cells |
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