A mouse model for β-thalassemia

A mutation that produces an absolute deficiency of normal β-major globin polypeptides has been recovered from a DBA/2J male mouse. Most mice homozygous for the deficiency survived to adulthood and reproduced but were smaller at birth than their littermates and demonstrated a hypochromic, microcytic...

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Veröffentlicht in:	Cell 1983-01, Vol.34 (3), p.1043-1052
Hauptverfasser:	Skow, L.C., Burkhart, B.A., Johnson, F.M., Popp, R.A., Popp, D.M., Goldberg, S.Z., Anderson, W.F., Barnett, L.B., Lewis, S.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromosome Deletion Classical genetics, quantitative genetics, hybrids Disease Models, Animal DNA - analysis DNA Restriction Enzymes - metabolism Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Globins - genetics Hemoglobins - analysis Human Male Mice Mice, Inbred C57BL Mice, Inbred DBA Thalassemia - genetics
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