Placental transport of metoclopramide: assessment of maternal and neonatal effects
Twenty-three patients undergoing general anaesthesia for Caesarian section for healthy term pregnancies were entered into a double blind study using metoclopramide (MCP) and a normal saline placebo. Of these patients, eight received intravenous metoclopramide, 12 a normal saline placebo and three we...
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| Veröffentlicht in: | Canadian Anaesthetists' Society journal 1983-09, Vol.30 (5), p.487-492 |
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| container_end_page | 492 |
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| container_issue | 5 |
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| container_title | Canadian Anaesthetists' Society journal |
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| creator | Bylsma-Howell, M Riggs, K W McMorland, G H Rurak, D W Ongley, R McErlane, B Price, J D Axelson, J E |
| description | Twenty-three patients undergoing general anaesthesia for Caesarian section for healthy term pregnancies were entered into a double blind study using metoclopramide (MCP) and a normal saline placebo. Of these patients, eight received intravenous metoclopramide, 12 a normal saline placebo and three were lost to clinical follow-up. The maternal gastric volumes were measured and maternal and foetal MCP plasma concentrations were determined by gas-liquid chromatography. The Neurological and Adaptive Capacity Score tests of Amiel, Barrier and Schnider (NACS) were used to attempt evaluation of neonatal responses to MCP. Maternal gastric volume was significantly lower (p less than 0.05) in the treated patients. There were no marked differences in Apgar scores, cardiovascular parameters or neurobehavioural scores between the treated and untreated groups of neonates. At no time were the foetal metoclopramide plasma concentrations observed to exceed maternal values. |
| doi_str_mv | 10.1007/BF03007082 |
| format | Article |
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Of these patients, eight received intravenous metoclopramide, 12 a normal saline placebo and three were lost to clinical follow-up. The maternal gastric volumes were measured and maternal and foetal MCP plasma concentrations were determined by gas-liquid chromatography. The Neurological and Adaptive Capacity Score tests of Amiel, Barrier and Schnider (NACS) were used to attempt evaluation of neonatal responses to MCP. Maternal gastric volume was significantly lower (p less than 0.05) in the treated patients. There were no marked differences in Apgar scores, cardiovascular parameters or neurobehavioural scores between the treated and untreated groups of neonates. At no time were the foetal metoclopramide plasma concentrations observed to exceed maternal values.</description><subject>Adult</subject><subject>Anesthesia, General</subject><subject>Anesthesia, Obstetrical</subject><subject>Apgar Score</subject><subject>Cesarean Section</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Maternal-Fetal Exchange</subject><subject>Metoclopramide - therapeutic use</subject><subject>Neurologic Examination</subject><subject>Pneumonia, Aspiration - prevention & control</subject><subject>Pregnancy</subject><issn>0008-2856</issn><issn>1496-8975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLxDAQhYMo67p68S705EGoJp0mTb3p4qqwoIieyzSdwErb1CQ9-O_tuoue3mG-9xg-xs4FvxacFzf3Kw5Tcp0dsLnIS5XqspCHbM4512mmpTpmJyF8cg5Q5HLGZgpkDlrO2dtri4b6iG0SPfZhcD4mziYdRWdaN3jsNg3dJhgChdBN5O8VI_l-6mDfJD25HrcDZC2ZGE7ZkcU20Nk-F-xj9fC-fErXL4_Py7t1akDomGZWUCNFiVyAgIzXGhWQMkZrlIW0UtlGaMxJiFpTZqyVQNoANBKUqWtYsMvd7uDd10ghVt0mGGpbnD4aQ6W5KiWU2QRe7UDjXQiebDX4TYf-uxK82gqs_gVO8MV-daw7av7QvTH4AWRXa54</recordid><startdate>198309</startdate><enddate>198309</enddate><creator>Bylsma-Howell, M</creator><creator>Riggs, K W</creator><creator>McMorland, G H</creator><creator>Rurak, D W</creator><creator>Ongley, R</creator><creator>McErlane, B</creator><creator>Price, J D</creator><creator>Axelson, J E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198309</creationdate><title>Placental transport of metoclopramide: assessment of maternal and neonatal effects</title><author>Bylsma-Howell, M ; Riggs, K W ; McMorland, G H ; Rurak, D W ; Ongley, R ; McErlane, B ; Price, J D ; Axelson, J E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-2f1ed519a0131320b8a63e6cc88a575f56fd18a4e11b8e2cff53e8c33d536cbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Anesthesia, General</topic><topic>Anesthesia, Obstetrical</topic><topic>Apgar Score</topic><topic>Cesarean Section</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Maternal-Fetal Exchange</topic><topic>Metoclopramide - therapeutic use</topic><topic>Neurologic Examination</topic><topic>Pneumonia, Aspiration - prevention & control</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bylsma-Howell, M</creatorcontrib><creatorcontrib>Riggs, K W</creatorcontrib><creatorcontrib>McMorland, G H</creatorcontrib><creatorcontrib>Rurak, D W</creatorcontrib><creatorcontrib>Ongley, R</creatorcontrib><creatorcontrib>McErlane, B</creatorcontrib><creatorcontrib>Price, J D</creatorcontrib><creatorcontrib>Axelson, J E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian Anaesthetists' Society journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bylsma-Howell, M</au><au>Riggs, K W</au><au>McMorland, G H</au><au>Rurak, D W</au><au>Ongley, R</au><au>McErlane, B</au><au>Price, J D</au><au>Axelson, J E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental transport of metoclopramide: assessment of maternal and neonatal effects</atitle><jtitle>Canadian Anaesthetists' Society journal</jtitle><addtitle>Can Anaesth Soc J</addtitle><date>1983-09</date><risdate>1983</risdate><volume>30</volume><issue>5</issue><spage>487</spage><epage>492</epage><pages>487-492</pages><issn>0008-2856</issn><eissn>1496-8975</eissn><abstract>Twenty-three patients undergoing general anaesthesia for Caesarian section for healthy term pregnancies were entered into a double blind study using metoclopramide (MCP) and a normal saline placebo. 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| fulltext | fulltext |
| identifier | ISSN: 0008-2856 |
| ispartof | Canadian Anaesthetists' Society journal, 1983-09, Vol.30 (5), p.487-492 |
| issn | 0008-2856 1496-8975 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80695392 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Anesthesia, General Anesthesia, Obstetrical Apgar Score Cesarean Section Clinical Trials as Topic Double-Blind Method Female Humans Infant, Newborn Male Maternal-Fetal Exchange Metoclopramide - therapeutic use Neurologic Examination Pneumonia, Aspiration - prevention & control Pregnancy |
| title | Placental transport of metoclopramide: assessment of maternal and neonatal effects |
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