Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium

Posttranslational modification of a structural protein by limited proteolysis is demonstrated for the first time in the nervous system. The 145,000 dalton subunit of neurofilaments in mouse retinal ganglion cell (RGC) axons is selectively converted in vitro to the major 143,000 and 140,000 dalton ne...

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Veröffentlicht in:	Brain research 1983-09, Vol.275 (2), p.384-388
Hauptverfasser:	Nixon, Ralph A., Brown, Beverly A., Marotta, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences calcium Calcium - metabolism Cell structures and functions cytoskeletal proteins Cytoskeleton, cytoplasm. Intracellular movements Electrophoresis, Polyacrylamide Gel Enzyme Activation Fundamental and applied biological sciences. Psychology Intermediate Filament Proteins - genetics Intermediate Filament Proteins - isolation & purification Kinetics Mice Mice, Inbred C57BL Molecular and cellular biology Molecular Weight mouse Neurofilament Proteins neurofilaments optic pathway Peptide Hydrolases - metabolism posttranslational modification Protein Processing, Post-Translational proteolysis retinal ganglion cells
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