Ethanol-induced alterations in rat hepatic ammonia metabolism
Alterations in the structure and physiology of experimental alcoholic liver injury have been the subject of many studies. Nevertheless, questions on other toxic effects during ethanol metabolism remain to be answered. The scope for the formation of other toxic agents during ethanol injection cannot...
Gespeichert in:
| Veröffentlicht in: | Biochemical pharmacology 1983-09, Vol.32 (18), p.2825-2827 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2827 |
|---|---|
| container_issue | 18 |
| container_start_page | 2825 |
| container_title | Biochemical pharmacology |
| container_volume | 32 |
| creator | Mohanachari, V. Satyavelu Reddy, K. Indira, K. |
| description | Alterations in the structure and physiology of experimental alcoholic liver injury have been the subject of many studies. Nevertheless, questions on other toxic effects during ethanol metabolism remain to be answered. The scope for the formation of other toxic agents during ethanol injection cannot be ruled out and more so, recent reports indicate, without definite conclusions, the interference of ammonia causing neurotoxicity, especially in severe alcoholic liver damage besides alterations in hepatic amino acid and protein metabolism. Hence in the present study the authors report some of the changes in the metabolic profiles of ammonia as a consequence of repeated loading of high doses of ethanol. This sort of study may help in understanding the chronic damage inflicted on the liver and the possible interplay of synergistic toxic agents like ammonia during ethanol ingestion. |
| doi_str_mv | 10.1016/0006-2952(83)90100-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80694044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006295283901004</els_id><sourcerecordid>80694044</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-8d7ee8dd0451fbbe77c996780de475417e87ff7b6b885cfca8b27a6180b63cdc3</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDNWnSJD0oyLJ-wIIXPYc0mWKkH2vSCv57U7fsUU-ZzDzzMjwInRJ8TTDhNxhjnmZFnl1KelVggnHK9tCcSEFjm8t9NN8hh-gohI_xKzmZoRnnGc9yOke3q_5dt12dutYOBmyi6x687l3XhsS1SSyTd9jEhkl003St00kDvS672oXmGB1Uug5wMr0L9Pawel0-peuXx-fl_To1jIg-lVYASGsxy0lVliCEKQouJLbARB4RkKKqRMlLKXNTGS3LTGhOJC45NdbQBbrY5m589zlA6FXjgoG61i10Q1AS84Jhxv4FCRUiLyiNINuCxncheKjUxrtG-29FsBr1qlGWGt0pSdWvXjXmn035Q9mA3S1NPuP8fJrrYHRded0aF3ZYwTIqcxyxuy0GUdqXA6-CcdBG_86D6ZXt3N93_ACCDJWy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13775933</pqid></control><display><type>article</type><title>Ethanol-induced alterations in rat hepatic ammonia metabolism</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Mohanachari, V. ; Satyavelu Reddy, K. ; Indira, K.</creator><creatorcontrib>Mohanachari, V. ; Satyavelu Reddy, K. ; Indira, K.</creatorcontrib><description>Alterations in the structure and physiology of experimental alcoholic liver injury have been the subject of many studies. Nevertheless, questions on other toxic effects during ethanol metabolism remain to be answered. The scope for the formation of other toxic agents during ethanol injection cannot be ruled out and more so, recent reports indicate, without definite conclusions, the interference of ammonia causing neurotoxicity, especially in severe alcoholic liver damage besides alterations in hepatic amino acid and protein metabolism. Hence in the present study the authors report some of the changes in the metabolic profiles of ammonia as a consequence of repeated loading of high doses of ethanol. This sort of study may help in understanding the chronic damage inflicted on the liver and the possible interplay of synergistic toxic agents like ammonia during ethanol ingestion.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(83)90100-4</identifier><identifier>PMID: 6626253</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alcoholism and acute alcohol poisoning ; ammonia ; Ammonia - metabolism ; Animals ; Biological and medical sciences ; Body Weight - drug effects ; Energy Intake ; Ethanol - pharmacology ; Glutamine - metabolism ; Kinetics ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; Organ Size - drug effects ; Rats ; Rats, Inbred Strains ; Toxicology ; Urea - metabolism</subject><ispartof>Biochemical pharmacology, 1983-09, Vol.32 (18), p.2825-2827</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8d7ee8dd0451fbbe77c996780de475417e87ff7b6b885cfca8b27a6180b63cdc3</citedby><cites>FETCH-LOGICAL-c417t-8d7ee8dd0451fbbe77c996780de475417e87ff7b6b885cfca8b27a6180b63cdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(83)90100-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9423850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6626253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohanachari, V.</creatorcontrib><creatorcontrib>Satyavelu Reddy, K.</creatorcontrib><creatorcontrib>Indira, K.</creatorcontrib><title>Ethanol-induced alterations in rat hepatic ammonia metabolism</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>Alterations in the structure and physiology of experimental alcoholic liver injury have been the subject of many studies. Nevertheless, questions on other toxic effects during ethanol metabolism remain to be answered. The scope for the formation of other toxic agents during ethanol injection cannot be ruled out and more so, recent reports indicate, without definite conclusions, the interference of ammonia causing neurotoxicity, especially in severe alcoholic liver damage besides alterations in hepatic amino acid and protein metabolism. Hence in the present study the authors report some of the changes in the metabolic profiles of ammonia as a consequence of repeated loading of high doses of ethanol. This sort of study may help in understanding the chronic damage inflicted on the liver and the possible interplay of synergistic toxic agents like ammonia during ethanol ingestion.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>ammonia</subject><subject>Ammonia - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Energy Intake</subject><subject>Ethanol - pharmacology</subject><subject>Glutamine - metabolism</subject><subject>Kinetics</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicology</subject><subject>Urea - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDNWnSJD0oyLJ-wIIXPYc0mWKkH2vSCv57U7fsUU-ZzDzzMjwInRJ8TTDhNxhjnmZFnl1KelVggnHK9tCcSEFjm8t9NN8hh-gohI_xKzmZoRnnGc9yOke3q_5dt12dutYOBmyi6x687l3XhsS1SSyTd9jEhkl003St00kDvS672oXmGB1Uug5wMr0L9Pawel0-peuXx-fl_To1jIg-lVYASGsxy0lVliCEKQouJLbARB4RkKKqRMlLKXNTGS3LTGhOJC45NdbQBbrY5m589zlA6FXjgoG61i10Q1AS84Jhxv4FCRUiLyiNINuCxncheKjUxrtG-29FsBr1qlGWGt0pSdWvXjXmn035Q9mA3S1NPuP8fJrrYHRded0aF3ZYwTIqcxyxuy0GUdqXA6-CcdBG_86D6ZXt3N93_ACCDJWy</recordid><startdate>19830915</startdate><enddate>19830915</enddate><creator>Mohanachari, V.</creator><creator>Satyavelu Reddy, K.</creator><creator>Indira, K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19830915</creationdate><title>Ethanol-induced alterations in rat hepatic ammonia metabolism</title><author>Mohanachari, V. ; Satyavelu Reddy, K. ; Indira, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8d7ee8dd0451fbbe77c996780de475417e87ff7b6b885cfca8b27a6180b63cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>ammonia</topic><topic>Ammonia - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Energy Intake</topic><topic>Ethanol - pharmacology</topic><topic>Glutamine - metabolism</topic><topic>Kinetics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicology</topic><topic>Urea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohanachari, V.</creatorcontrib><creatorcontrib>Satyavelu Reddy, K.</creatorcontrib><creatorcontrib>Indira, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohanachari, V.</au><au>Satyavelu Reddy, K.</au><au>Indira, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol-induced alterations in rat hepatic ammonia metabolism</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1983-09-15</date><risdate>1983</risdate><volume>32</volume><issue>18</issue><spage>2825</spage><epage>2827</epage><pages>2825-2827</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>Alterations in the structure and physiology of experimental alcoholic liver injury have been the subject of many studies. Nevertheless, questions on other toxic effects during ethanol metabolism remain to be answered. The scope for the formation of other toxic agents during ethanol injection cannot be ruled out and more so, recent reports indicate, without definite conclusions, the interference of ammonia causing neurotoxicity, especially in severe alcoholic liver damage besides alterations in hepatic amino acid and protein metabolism. Hence in the present study the authors report some of the changes in the metabolic profiles of ammonia as a consequence of repeated loading of high doses of ethanol. This sort of study may help in understanding the chronic damage inflicted on the liver and the possible interplay of synergistic toxic agents like ammonia during ethanol ingestion.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6626253</pmid><doi>10.1016/0006-2952(83)90100-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1983-09, Vol.32 (18), p.2825-2827 |
| issn | 0006-2952 1873-2968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80694044 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alcoholism and acute alcohol poisoning ammonia Ammonia - metabolism Animals Biological and medical sciences Body Weight - drug effects Energy Intake Ethanol - pharmacology Glutamine - metabolism Kinetics Liver - drug effects Liver - metabolism Male Medical sciences Organ Size - drug effects Rats Rats, Inbred Strains Toxicology Urea - metabolism |
| title | Ethanol-induced alterations in rat hepatic ammonia metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T15%3A56%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ethanol-induced%20alterations%20in%20rat%20hepatic%20ammonia%20metabolism&rft.jtitle=Biochemical%20pharmacology&rft.au=Mohanachari,%20V.&rft.date=1983-09-15&rft.volume=32&rft.issue=18&rft.spage=2825&rft.epage=2827&rft.pages=2825-2827&rft.issn=0006-2952&rft.eissn=1873-2968&rft.coden=BCPCA6&rft_id=info:doi/10.1016/0006-2952(83)90100-4&rft_dat=%3Cproquest_cross%3E80694044%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13775933&rft_id=info:pmid/6626253&rft_els_id=0006295283901004&rfr_iscdi=true |