Regulation by glucocorticoids of rat-liver phenylalanine hydroxylase In Vivo
Phenylalanine hydroxylase, a liver-associated enzyme, is induced markedly by glucocorticoids in two permanent rat-hepatoma cell lines. In order to gain evidence that this phenomenon also occurs in vivo, we examined the effect of adrenalectomy and/or hormone supplementation on the levels of phenylala...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1983-09, Vol.115 (3), p.965-970 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Haggerty, Donald F. Chiappelli, Francesco Kern, Rita Scully, Sheila Lynch, Maureen |
| description | Phenylalanine hydroxylase, a liver-associated enzyme, is induced markedly by glucocorticoids in two permanent rat-hepatoma cell lines. In order to gain evidence that this phenomenon also occurs
in vivo, we examined the effect of adrenalectomy and/or hormone supplementation on the levels of phenylalanine hydroxylase in the livers of adult rats: glucocorticoid administration increases, and adrenal ablation reduces, the activity of the hepatic enzyme, and the diminution occurring in the latter instance is entirely prevented by concurrent hormone replacement. These results thus corroborate earlier findings from a single experiment and are consistent with the hypothesis that adrenal corticosteroid hormones participate in modulating phenylalanine-hydroxylase levels within the diploid hepatocyte. |
| doi_str_mv | 10.1016/S0006-291X(83)80029-1 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1983-09, Vol.115 (3), p.965-970 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenalectomy Animals Brain - enzymology Enzyme Induction Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Hydrocortisone - pharmacology Kinetics Liver - drug effects Liver - enzymology Male Phenylalanine Hydroxylase - genetics Rats Rats, Inbred Strains |
| title | Regulation by glucocorticoids of rat-liver phenylalanine hydroxylase In Vivo |
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