Inhibition of polyamine biosynthesis in Crithidia fasciculata by d,l-α-difluoromethylornithine and d,l-α-difluoromethylarginine

Using Crithidia fasciculata as a model organism for Trypanosoma cruzi, we have examined the effects of d,l-α-difluoromethylornithine (DFMO) and d,l-α-difluoromethylarginine (DFMA) on growth and polyamine synthesis. In a defined, polyamine-free medium growth was markedly inhibited by DFMO (94% at 50...

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Veröffentlicht in:	Molecular and biochemical parasitology 1991-05, Vol.46 (1), p.35-43
Hauptverfasser:	Hunter, Karl J., Strobos, Carolyn A.M., Fairlamb, Alan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine - pharmacology Amidinotransferases - metabolism Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Arginase - metabolism Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Carboxy-Lyases - metabolism Crithidia - drug effects Crithidia - enzymology Crithidia - metabolism Eflornithine - pharmacology Kinetics Medical sciences Ornithine Decarboxylase - metabolism Ornithine Decarboxylase Inhibitors Pharmacology. Drug treatments Polyamine Polyamines - metabolism Putrescine - pharmacology Trypanosomatid Trypanothione α-Difluoromethylarginine α-Difluoromethylornithine
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