Plaque-forming cells in man. II: Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders
When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days...
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| Veröffentlicht in: | Scandinavian journal of immunology 1983-09, Vol.18 (3), p.249-253 |
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| container_title | Scandinavian journal of immunology |
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| creator | TAURIS, P |
| description | When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irradiation on normal PFC responders and non-responders was also investigated; 2000-rad-irradiated non-responder T lymphocytes co-cultured with autologous untreated B lymphocytes restored the PFC response to normal levels. The evidence of a high level of suppressor activity in non-responder T lymphocytes was further demonstrated by the decreased PFC response of normal B lymphocytes co-cultured with untreated non-responder T lymphocytes. |
| doi_str_mv | 10.1111/j.1365-3083.1983.tb00864.x |
| format | Article |
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The evidence of a high level of suppressor activity in non-responder T lymphocytes was further demonstrated by the decreased PFC response of normal B lymphocytes co-cultured with untreated non-responder T lymphocytes.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.1983.tb00864.x</identifier><identifier>PMID: 6226090</identifier><identifier>CODEN: SJIMAX</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Analysis of the immune response. Humoral and cellular immunity ; Antibody-Producing Cells - immunology ; Antibody-Producing Cells - radiation effects ; B-Lymphocytes - immunology ; Biological and medical sciences ; Dose-Response Relationship, Immunologic ; Fundamental and applied biological sciences. 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II: Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irradiation on normal PFC responders and non-responders was also investigated; 2000-rad-irradiated non-responder T lymphocytes co-cultured with autologous untreated B lymphocytes restored the PFC response to normal levels. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Hemolytic Plaque Technique</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunobiology</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Middle Aged</subject><subject>Organs and cells involved in the immune response</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - radiation effects</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUU1v1DAUtBCoLIWfgGQhxC3BjpM47g1VBVaqVA5wtvzxTL1K7GBnq-WP8Htx1LAc6oOt55k38_QGoXeU1LScj4easr6rGBlYTUW5Fk3I0Lf16RnanaHnaEcYIZVoefcSvcr5QAhlDWcX6KJvmp4IskN_vo3q1xEqF9Pkw09sYBwz9gFPKtR4v7_CNw_eQjCAo8PLPWA4-bz8-1Bm8Q-A83GeE-Qc03-BGZKf7yGpEesxRrvSQ3Ep9fzUs0ChKhJzDBZSfo1eODVmeLO9l-jH55vv11-r27sv--tPt5VpCF0qy3kPwlljOO0sN6YblO60ErxtoXONbamg1jrdc02JMkqLhjnGRWudaTVhl-jDo-6cYhkpL3LyeZ1HBYjHLAfSD3wgbSFePRJNijkncHJOflLpt6RErqHIg1w3L9fNyzUUuYUiT6X57eZy1BPYc-uWQsHfb7jKRo0uqWB8PtME6-jQUfYXXq-aCg</recordid><startdate>198309</startdate><enddate>198309</enddate><creator>TAURIS, P</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198309</creationdate><title>Plaque-forming cells in man. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Hemolytic Plaque Technique</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunobiology</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Middle Aged</topic><topic>Organs and cells involved in the immune response</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAURIS, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAURIS, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plaque-forming cells in man. II: Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1983-09</date><risdate>1983</risdate><volume>18</volume><issue>3</issue><spage>249</spage><epage>253</epage><pages>249-253</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><coden>SJIMAX</coden><abstract>When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irradiation on normal PFC responders and non-responders was also investigated; 2000-rad-irradiated non-responder T lymphocytes co-cultured with autologous untreated B lymphocytes restored the PFC response to normal levels. 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| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 1983-09, Vol.18 (3), p.249-253 |
| issn | 0300-9475 1365-3083 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Analysis of the immune response. Humoral and cellular immunity Antibody-Producing Cells - immunology Antibody-Producing Cells - radiation effects B-Lymphocytes - immunology Biological and medical sciences Dose-Response Relationship, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Hemolytic Plaque Technique Humans Immune Tolerance Immunobiology Immunoglobulins - biosynthesis Middle Aged Organs and cells involved in the immune response T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects |
| title | Plaque-forming cells in man. II: Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders |
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