The pathogenesis of rheumatoid arthritis and the immune response
The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared t...
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| Veröffentlicht in: | Semin. Arthritis Rheum.; (United States) 1983-08, Vol.13 (1), p.99-101 |
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| container_title | Semin. Arthritis Rheum.; (United States) |
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| creator | Scheinberg, Morton A. |
| description | The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation. |
| doi_str_mv | 10.1016/0049-0172(83)90027-6 |
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In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/0049-0172(83)90027-6</identifier><identifier>PMID: 6414086</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man ; Arthritis, Rheumatoid - etiology ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - therapy ; Auranofin ; Aurothioglucose - analogs & derivatives ; Aurothioglucose - therapeutic use ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; BONE JOINTS ; Cells, Cultured ; Chemotaxis - drug effects ; CHEMOTHERAPY ; COMPARATIVE EVALUATIONS ; ETIOLOGY ; Female ; GOLD ISOTOPES ; Gold Sodium Thiomalate - therapeutic use ; Humans ; INFLAMMATION ; IRRADIATION ; ISOTOPES ; Lymph Nodes - radiation effects ; LYMPHATIC SYSTEM ; Male ; MEDICINE ; Monocytes - drug effects ; Monocytes - immunology ; NUCLEAR MEDICINE ; ORGANS ; PATHOGENESIS ; PATHOLOGICAL CHANGES ; PATIENTS ; Plasmapheresis ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. 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Arthritis Rheum.; (United States)</title><addtitle>Semin Arthritis Rheum</addtitle><description>The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.</description><subject>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man</subject><subject>Arthritis, Rheumatoid - etiology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - therapy</subject><subject>Auranofin</subject><subject>Aurothioglucose - analogs & derivatives</subject><subject>Aurothioglucose - therapeutic use</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BONE JOINTS</subject><subject>Cells, Cultured</subject><subject>Chemotaxis - drug effects</subject><subject>CHEMOTHERAPY</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>ETIOLOGY</subject><subject>Female</subject><subject>GOLD ISOTOPES</subject><subject>Gold Sodium Thiomalate - therapeutic use</subject><subject>Humans</subject><subject>INFLAMMATION</subject><subject>IRRADIATION</subject><subject>ISOTOPES</subject><subject>Lymph Nodes - radiation effects</subject><subject>LYMPHATIC SYSTEM</subject><subject>Male</subject><subject>MEDICINE</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANS</subject><subject>PATHOGENESIS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PATIENTS</subject><subject>Plasmapheresis</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. 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Arthritis Rheum.; (United States)</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>1983-08</date><risdate>1983</risdate><volume>13</volume><issue>1</issue><spage>99</spage><epage>101</epage><pages>99-101</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><abstract>The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6414086</pmid><doi>10.1016/0049-0172(83)90027-6</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-0172 |
| ispartof | Semin. Arthritis Rheum.; (United States), 1983-08, Vol.13 (1), p.99-101 |
| issn | 0049-0172 1532-866X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Auranofin Aurothioglucose - analogs & derivatives Aurothioglucose - therapeutic use BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BONE JOINTS Cells, Cultured Chemotaxis - drug effects CHEMOTHERAPY COMPARATIVE EVALUATIONS ETIOLOGY Female GOLD ISOTOPES Gold Sodium Thiomalate - therapeutic use Humans INFLAMMATION IRRADIATION ISOTOPES Lymph Nodes - radiation effects LYMPHATIC SYSTEM Male MEDICINE Monocytes - drug effects Monocytes - immunology NUCLEAR MEDICINE ORGANS PATHOGENESIS PATHOLOGICAL CHANGES PATIENTS Plasmapheresis RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOLOGY RADIOTHERAPY SKELETON SYMPTOMS THERAPY |
| title | The pathogenesis of rheumatoid arthritis and the immune response |
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