On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients
Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. We found also a negative associati...
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| Veröffentlicht in: | Journal of investigative dermatology 1991-08, Vol.97 (2), p.269-272 |
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| container_title | Journal of investigative dermatology |
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| creator | Bavinck, Jan N Bouwes Kootte, Antoinette M M Woude, Fokko J Van Der Vandenbroucke, Jan P Vermeer, Bert J Claas, Frans H J |
| description | Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens. |
| doi_str_mv | 10.1111/1523-1747.ep12480376 |
| format | Article |
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We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12480376</identifier><identifier>PMID: 1649229</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Alleles ; Biological and medical sciences ; Carcinoma, Basal Cell - immunology ; Carcinoma, Basal Cell - microbiology ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - microbiology ; Cervical carcinoma ; Cervix ; Cytotoxicity ; Dermatology ; Histocompatibility antigen HLA ; HLA-A Antigens - genetics ; HLA-A Antigens - immunology ; HLA-A11 Antigen ; Human papillomavirus ; Humans ; Keratosis - immunology ; Keratosis - microbiology ; Kidney transplantation ; Kidney Transplantation - immunology ; Kidney Transplantation - physiology ; Lymphocytes T ; Medical sciences ; Papillomaviridae ; Risk assessment ; Skin cancer ; Skin diseases ; Skin Neoplasms - immunology ; Skin Neoplasms - microbiology ; squamous cell carcinoma ; Tumors of the skin and soft tissue. 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We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens.</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Basal Cell - immunology</subject><subject>Carcinoma, Basal Cell - microbiology</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - microbiology</subject><subject>Cervical carcinoma</subject><subject>Cervix</subject><subject>Cytotoxicity</subject><subject>Dermatology</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-A Antigens - genetics</subject><subject>HLA-A Antigens - immunology</subject><subject>HLA-A11 Antigen</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Keratosis - immunology</subject><subject>Keratosis - microbiology</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - immunology</subject><subject>Kidney Transplantation - physiology</subject><subject>Lymphocytes T</subject><subject>Medical sciences</subject><subject>Papillomaviridae</subject><subject>Risk assessment</subject><subject>Skin cancer</subject><subject>Skin diseases</subject><subject>Skin Neoplasms - immunology</subject><subject>Skin Neoplasms - microbiology</subject><subject>squamous cell carcinoma</subject><subject>Tumors of the skin and soft tissue. 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Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bavinck, Jan N Bouwes</creatorcontrib><creatorcontrib>Kootte, Antoinette M M</creatorcontrib><creatorcontrib>Woude, Fokko J Van Der</creatorcontrib><creatorcontrib>Vandenbroucke, Jan P</creatorcontrib><creatorcontrib>Vermeer, Bert J</creatorcontrib><creatorcontrib>Claas, Frans H J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bavinck, Jan N Bouwes</au><au>Kootte, Antoinette M M</au><au>Woude, Fokko J Van Der</au><au>Vandenbroucke, Jan P</au><au>Vermeer, Bert J</au><au>Claas, Frans H J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>97</volume><issue>2</issue><spage>269</spage><epage>272</epage><pages>269-272</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. 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| ispartof | Journal of investigative dermatology, 1991-08, Vol.97 (2), p.269-272 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alleles Biological and medical sciences Carcinoma, Basal Cell - immunology Carcinoma, Basal Cell - microbiology Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - microbiology Cervical carcinoma Cervix Cytotoxicity Dermatology Histocompatibility antigen HLA HLA-A Antigens - genetics HLA-A Antigens - immunology HLA-A11 Antigen Human papillomavirus Humans Keratosis - immunology Keratosis - microbiology Kidney transplantation Kidney Transplantation - immunology Kidney Transplantation - physiology Lymphocytes T Medical sciences Papillomaviridae Risk assessment Skin cancer Skin diseases Skin Neoplasms - immunology Skin Neoplasms - microbiology squamous cell carcinoma Tumors of the skin and soft tissue. Premalignant lesions |
| title | On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients |
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