Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants
Sixteen healthy very low birth weight infants (VLBWI) were studied in a serial fashion over a 3-week period. Subjects were evaluated for lymphocyte phenotype, phytohemagglutinin (PHA) response, and metabolic status including weight, blood urea nitrogen, creatinine, albumin, pH, calcium, phosphorus,...
Gespeichert in:
| Veröffentlicht in: | Clinical immunology and immunopathology 1991-08, Vol.60 (2), p.268-277 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 277 |
|---|---|
| container_issue | 2 |
| container_start_page | 268 |
| container_title | Clinical immunology and immunopathology |
| container_volume | 60 |
| creator | Herrod, Henry G. Cooke, Richard J. Valenski, William R. Herman, Jeanne Dockter, Michael E. |
| description | Sixteen healthy very low birth weight infants (VLBWI) were studied in a serial fashion over a 3-week period. Subjects were evaluated for lymphocyte phenotype, phytohemagglutinin (PHA) response, and metabolic status including weight, blood urea nitrogen, creatinine, albumin, pH, calcium, phosphorus, and ammonia. Lymphocyte phenotype determination showed a decreased proportion of CD3+ cells (66.8 ± 10.4 vs 75.9 ± 6.1,
P < 0.02) in VLBWI. When subsets of the CD4+ population were examined, VLBWI had a lower proportion of
CD4+
CD29+
cells (8.2 ± 5.8% vs 23.5 ± 8.0%,
P < 0.0001) than adults and a higher proportion of
CD4+
CD45R+
cells (35.6 ± 12.4% vs 22.2 ± 7.4%,
P < 0.03). The CD4+ subsets in VLBWI were similar to those seen in term infants. The peak PHA response in VLBWI was greater than that of adults (
P < 0.01). There was little change in the immune measurements over the 3-week study period. There were no strong correlations between any of the immunological measurements and the metabolic measurements except that the proportion of CD8+ cells increased with birth weight. Our findings demonstrate that immune measurements in healthy VLBWI differ from values found in adults but are similar to those of full-term infants. Lower proportions of the
CD4+
CD29+
cells (the helper/inducer subset for antibody production) may contribute to some of the differences in immune function reported in neonates. |
| doi_str_mv | 10.1016/0090-1229(91)90069-M |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80681082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>009012299190069M</els_id><sourcerecordid>80681082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-88e7d49cf99c77c9fe59caf40ef2187464df907426a1b46293a930cc3c92cd1e3</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EKtvCG4DkE4JDYOx44_iCVFWlILXiAmfL64w3hsQOtrNV3p4su-qRk-2Zb_6RP0LeMPjIgDWfABRUjHP1XrEPCqBR1cMzsmHHMq8Fe042T8hLcpnzL1ghAfKCXHCQsJWwIb9vD2aYTfEx0OjosIxTH-1SkE49hliWCakJ3fpaSuxxNPv9MBcffKAJ8xRDRrreezRD6Rd6wLTQIT7SnU-lp4_o931ZAWdCya_IC2eGjK_P5xX5-eX2x83X6v773beb6_vK1ltZqrZF2QllnVJWSqscbpU1TgA6zlopGtE5BVLwxrCdaLiqjarB2toqbjuG9RV5d8qdUvwzYy569NniMJiAcc66haZl0PIVFCfQpphzQqen5EeTFs1AHx3ro0B9FKgV0_8c64d17O05f96N2D0NnaWu_c-nPq6fPHhMOluPwWLnE9qiu-j_v-AvNeiN2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80681082</pqid></control><display><type>article</type><title>Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Herrod, Henry G. ; Cooke, Richard J. ; Valenski, William R. ; Herman, Jeanne ; Dockter, Michael E.</creator><creatorcontrib>Herrod, Henry G. ; Cooke, Richard J. ; Valenski, William R. ; Herman, Jeanne ; Dockter, Michael E.</creatorcontrib><description>Sixteen healthy very low birth weight infants (VLBWI) were studied in a serial fashion over a 3-week period. Subjects were evaluated for lymphocyte phenotype, phytohemagglutinin (PHA) response, and metabolic status including weight, blood urea nitrogen, creatinine, albumin, pH, calcium, phosphorus, and ammonia. Lymphocyte phenotype determination showed a decreased proportion of CD3+ cells (66.8 ± 10.4 vs 75.9 ± 6.1,
P < 0.02) in VLBWI. When subsets of the CD4+ population were examined, VLBWI had a lower proportion of
CD4+
CD29+
cells (8.2 ± 5.8% vs 23.5 ± 8.0%,
P < 0.0001) than adults and a higher proportion of
CD4+
CD45R+
cells (35.6 ± 12.4% vs 22.2 ± 7.4%,
P < 0.03). The CD4+ subsets in VLBWI were similar to those seen in term infants. The peak PHA response in VLBWI was greater than that of adults (
P < 0.01). There was little change in the immune measurements over the 3-week study period. There were no strong correlations between any of the immunological measurements and the metabolic measurements except that the proportion of CD8+ cells increased with birth weight. Our findings demonstrate that immune measurements in healthy VLBWI differ from values found in adults but are similar to those of full-term infants. Lower proportions of the
CD4+
CD29+
cells (the helper/inducer subset for antibody production) may contribute to some of the differences in immune function reported in neonates.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(91)90069-M</identifier><identifier>PMID: 2070570</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ammonia - blood ; Antigens, CD - analysis ; Birth Weight ; Blood Proteins - analysis ; Blood Urea Nitrogen ; Creatinine - blood ; Humans ; Immunophenotyping ; Infant, Low Birth Weight - immunology ; Infant, Low Birth Weight - metabolism ; Infant, Newborn ; Lymphocyte Activation ; Lymphocyte Subsets - immunology ; Phosphorus - blood ; Phytohemagglutinins - pharmacology</subject><ispartof>Clinical immunology and immunopathology, 1991-08, Vol.60 (2), p.268-277</ispartof><rights>1991</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-88e7d49cf99c77c9fe59caf40ef2187464df907426a1b46293a930cc3c92cd1e3</citedby><cites>FETCH-LOGICAL-c357t-88e7d49cf99c77c9fe59caf40ef2187464df907426a1b46293a930cc3c92cd1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2070570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrod, Henry G.</creatorcontrib><creatorcontrib>Cooke, Richard J.</creatorcontrib><creatorcontrib>Valenski, William R.</creatorcontrib><creatorcontrib>Herman, Jeanne</creatorcontrib><creatorcontrib>Dockter, Michael E.</creatorcontrib><title>Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Sixteen healthy very low birth weight infants (VLBWI) were studied in a serial fashion over a 3-week period. Subjects were evaluated for lymphocyte phenotype, phytohemagglutinin (PHA) response, and metabolic status including weight, blood urea nitrogen, creatinine, albumin, pH, calcium, phosphorus, and ammonia. Lymphocyte phenotype determination showed a decreased proportion of CD3+ cells (66.8 ± 10.4 vs 75.9 ± 6.1,
P < 0.02) in VLBWI. When subsets of the CD4+ population were examined, VLBWI had a lower proportion of
CD4+
CD29+
cells (8.2 ± 5.8% vs 23.5 ± 8.0%,
P < 0.0001) than adults and a higher proportion of
CD4+
CD45R+
cells (35.6 ± 12.4% vs 22.2 ± 7.4%,
P < 0.03). The CD4+ subsets in VLBWI were similar to those seen in term infants. The peak PHA response in VLBWI was greater than that of adults (
P < 0.01). There was little change in the immune measurements over the 3-week study period. There were no strong correlations between any of the immunological measurements and the metabolic measurements except that the proportion of CD8+ cells increased with birth weight. Our findings demonstrate that immune measurements in healthy VLBWI differ from values found in adults but are similar to those of full-term infants. Lower proportions of the
CD4+
CD29+
cells (the helper/inducer subset for antibody production) may contribute to some of the differences in immune function reported in neonates.</description><subject>Ammonia - blood</subject><subject>Antigens, CD - analysis</subject><subject>Birth Weight</subject><subject>Blood Proteins - analysis</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine - blood</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Infant, Low Birth Weight - immunology</subject><subject>Infant, Low Birth Weight - metabolism</subject><subject>Infant, Newborn</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Phosphorus - blood</subject><subject>Phytohemagglutinins - pharmacology</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKtvCG4DkE4JDYOx44_iCVFWlILXiAmfL64w3hsQOtrNV3p4su-qRk-2Zb_6RP0LeMPjIgDWfABRUjHP1XrEPCqBR1cMzsmHHMq8Fe042T8hLcpnzL1ghAfKCXHCQsJWwIb9vD2aYTfEx0OjosIxTH-1SkE49hliWCakJ3fpaSuxxNPv9MBcffKAJ8xRDRrreezRD6Rd6wLTQIT7SnU-lp4_o931ZAWdCya_IC2eGjK_P5xX5-eX2x83X6v773beb6_vK1ltZqrZF2QllnVJWSqscbpU1TgA6zlopGtE5BVLwxrCdaLiqjarB2toqbjuG9RV5d8qdUvwzYy569NniMJiAcc66haZl0PIVFCfQpphzQqen5EeTFs1AHx3ro0B9FKgV0_8c64d17O05f96N2D0NnaWu_c-nPq6fPHhMOluPwWLnE9qiu-j_v-AvNeiN2Q</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Herrod, Henry G.</creator><creator>Cooke, Richard J.</creator><creator>Valenski, William R.</creator><creator>Herman, Jeanne</creator><creator>Dockter, Michael E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910801</creationdate><title>Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants</title><author>Herrod, Henry G. ; Cooke, Richard J. ; Valenski, William R. ; Herman, Jeanne ; Dockter, Michael E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-88e7d49cf99c77c9fe59caf40ef2187464df907426a1b46293a930cc3c92cd1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Ammonia - blood</topic><topic>Antigens, CD - analysis</topic><topic>Birth Weight</topic><topic>Blood Proteins - analysis</topic><topic>Blood Urea Nitrogen</topic><topic>Creatinine - blood</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Infant, Low Birth Weight - immunology</topic><topic>Infant, Low Birth Weight - metabolism</topic><topic>Infant, Newborn</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Phosphorus - blood</topic><topic>Phytohemagglutinins - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Herrod, Henry G.</creatorcontrib><creatorcontrib>Cooke, Richard J.</creatorcontrib><creatorcontrib>Valenski, William R.</creatorcontrib><creatorcontrib>Herman, Jeanne</creatorcontrib><creatorcontrib>Dockter, Michael E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrod, Henry G.</au><au>Cooke, Richard J.</au><au>Valenski, William R.</au><au>Herman, Jeanne</au><au>Dockter, Michael E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>60</volume><issue>2</issue><spage>268</spage><epage>277</epage><pages>268-277</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><abstract>Sixteen healthy very low birth weight infants (VLBWI) were studied in a serial fashion over a 3-week period. Subjects were evaluated for lymphocyte phenotype, phytohemagglutinin (PHA) response, and metabolic status including weight, blood urea nitrogen, creatinine, albumin, pH, calcium, phosphorus, and ammonia. Lymphocyte phenotype determination showed a decreased proportion of CD3+ cells (66.8 ± 10.4 vs 75.9 ± 6.1,
P < 0.02) in VLBWI. When subsets of the CD4+ population were examined, VLBWI had a lower proportion of
CD4+
CD29+
cells (8.2 ± 5.8% vs 23.5 ± 8.0%,
P < 0.0001) than adults and a higher proportion of
CD4+
CD45R+
cells (35.6 ± 12.4% vs 22.2 ± 7.4%,
P < 0.03). The CD4+ subsets in VLBWI were similar to those seen in term infants. The peak PHA response in VLBWI was greater than that of adults (
P < 0.01). There was little change in the immune measurements over the 3-week study period. There were no strong correlations between any of the immunological measurements and the metabolic measurements except that the proportion of CD8+ cells increased with birth weight. Our findings demonstrate that immune measurements in healthy VLBWI differ from values found in adults but are similar to those of full-term infants. Lower proportions of the
CD4+
CD29+
cells (the helper/inducer subset for antibody production) may contribute to some of the differences in immune function reported in neonates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2070570</pmid><doi>10.1016/0090-1229(91)90069-M</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-1229 |
| ispartof | Clinical immunology and immunopathology, 1991-08, Vol.60 (2), p.268-277 |
| issn | 0090-1229 1090-2341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80681082 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Ammonia - blood Antigens, CD - analysis Birth Weight Blood Proteins - analysis Blood Urea Nitrogen Creatinine - blood Humans Immunophenotyping Infant, Low Birth Weight - immunology Infant, Low Birth Weight - metabolism Infant, Newborn Lymphocyte Activation Lymphocyte Subsets - immunology Phosphorus - blood Phytohemagglutinins - pharmacology |
| title | Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T15%3A37%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20lymphocyte%20phenotype%20and%20phytohemagglutinin%20response%20in%20healthy%20very%20low%20birth%20weight%20infants&rft.jtitle=Clinical%20immunology%20and%20immunopathology&rft.au=Herrod,%20Henry%20G.&rft.date=1991-08-01&rft.volume=60&rft.issue=2&rft.spage=268&rft.epage=277&rft.pages=268-277&rft.issn=0090-1229&rft.eissn=1090-2341&rft_id=info:doi/10.1016/0090-1229(91)90069-M&rft_dat=%3Cproquest_cross%3E80681082%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80681082&rft_id=info:pmid/2070570&rft_els_id=009012299190069M&rfr_iscdi=true |