Substance P innervation of spleen in rats: Nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen
We investigated the distribution of SP+ nerve fibers in the spleen of adult male Fischer 344 rats. SP+ nerve fibers entered the spleen with the splenic artery in the hilar region, arborized along the venous sinuses, and extended from these larger plexuses into trabeculae and the surrounding red pulp...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 1991-03, Vol.5 (1), p.29-40 |
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| creator | Lorton, D. Bellinger, D.L. Felten, S.Y. Felten, D.L. |
| description | We investigated the distribution of SP+ nerve fibers in the spleen of adult male Fischer 344 rats. SP+ nerve fibers entered the spleen with the splenic artery in the hilar region, arborized along the venous sinuses, and extended from these larger plexuses into trabeculae and the surrounding red pulp. In the white pulp, SP+ nerve fibers were found in the marginal zone, and in the outer regions of the PALS among T lymphocytes. No SP+ nerve fibers were observed in association with the splenic capsule, the central arteries of the white pulp, or the follicles. SP levels in rat spleen were 5.7 ± 0.4 ng/g wet wt. On the basis of the present findings of SP presence in nerve fibers in the spleen, and published evidence for SP receptors on lymphocytes and macrophages, we suggest that SP derived from nerve fibers in the spleen can act as a neurotransmitter with cells of the immune system as targets. These SP nerve fibers may be an important neural link between the nervous system and the immune system and may participate in modulation of immune reactivity and inflammatory responses. |
| doi_str_mv | 10.1016/0889-1591(91)90005-U |
| format | Article |
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SP+ nerve fibers entered the spleen with the splenic artery in the hilar region, arborized along the venous sinuses, and extended from these larger plexuses into trabeculae and the surrounding red pulp. In the white pulp, SP+ nerve fibers were found in the marginal zone, and in the outer regions of the PALS among T lymphocytes. No SP+ nerve fibers were observed in association with the splenic capsule, the central arteries of the white pulp, or the follicles. SP levels in rat spleen were 5.7 ± 0.4 ng/g wet wt. On the basis of the present findings of SP presence in nerve fibers in the spleen, and published evidence for SP receptors on lymphocytes and macrophages, we suggest that SP derived from nerve fibers in the spleen can act as a neurotransmitter with cells of the immune system as targets. These SP nerve fibers may be an important neural link between the nervous system and the immune system and may participate in modulation of immune reactivity and inflammatory responses.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/0889-1591(91)90005-U</identifier><identifier>PMID: 1712652</identifier><identifier>CODEN: BBIMEW</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; Lymphoid organs: ontogeny, organization, homing phenomenon ; Macrophages ; Male ; Nerve Fibers - chemistry ; Neuroimmunomodulation - physiology ; Rats ; Rats, Inbred F344 ; Rats, Inbred Strains ; Spleen - cytology ; Spleen - innervation ; Spleen - ultrastructure ; Substance P - analysis ; Substance P - physiology ; T-Lymphocytes</subject><ispartof>Brain, behavior, and immunity, 1991-03, Vol.5 (1), p.29-40</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-5e9cbe4937e02814d214accfaa8d8a8d0615d915daf814f2ab94fd7386abdbfe3</citedby><cites>FETCH-LOGICAL-c464t-5e9cbe4937e02814d214accfaa8d8a8d0615d915daf814f2ab94fd7386abdbfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0889-1591(91)90005-U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19665173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1712652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorton, D.</creatorcontrib><creatorcontrib>Bellinger, D.L.</creatorcontrib><creatorcontrib>Felten, S.Y.</creatorcontrib><creatorcontrib>Felten, D.L.</creatorcontrib><title>Substance P innervation of spleen in rats: Nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>We investigated the distribution of SP+ nerve fibers in the spleen of adult male Fischer 344 rats. SP+ nerve fibers entered the spleen with the splenic artery in the hilar region, arborized along the venous sinuses, and extended from these larger plexuses into trabeculae and the surrounding red pulp. In the white pulp, SP+ nerve fibers were found in the marginal zone, and in the outer regions of the PALS among T lymphocytes. No SP+ nerve fibers were observed in association with the splenic capsule, the central arteries of the white pulp, or the follicles. SP levels in rat spleen were 5.7 ± 0.4 ng/g wet wt. On the basis of the present findings of SP presence in nerve fibers in the spleen, and published evidence for SP receptors on lymphocytes and macrophages, we suggest that SP derived from nerve fibers in the spleen can act as a neurotransmitter with cells of the immune system as targets. These SP nerve fibers may be an important neural link between the nervous system and the immune system and may participate in modulation of immune reactivity and inflammatory responses.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Lymphoid organs: ontogeny, organization, homing phenomenon</subject><subject>Macrophages</subject><subject>Male</subject><subject>Nerve Fibers - chemistry</subject><subject>Neuroimmunomodulation - physiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Strains</subject><subject>Spleen - cytology</subject><subject>Spleen - innervation</subject><subject>Spleen - ultrastructure</subject><subject>Substance P - analysis</subject><subject>Substance P - physiology</subject><subject>T-Lymphocytes</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduKFDEQhoMo67j6Bgq5UdaL1qQP6Y4XgiyeYFFB5zpUJxUn0qdNZXaZR_CtTTODe6eQIlT-r6qS_Iw9leKVFFK9Fl2nC9loeaHlSy2EaIrtPbaRQouilJW-zzZ_kYfsEdGvlalkd8bOZCtL1ZQb9vv7vqcEk0X-jYdpwngDKcwTnz2nZUCc8imPkOgN_5JF5D70GIkD0WwDJOS3Ie34cBiX3WwPCbM0OT6CjfOyg585zw1oQRt8sNzO4wIxjTglWmekHZ7mPGYPPAyET077Odt-eP_j8lNx9fXj58t3V4WtVZ2KBrXtsdZVi6LsZO1KWYO1HqBzXQ6hZON0DvBZ9SX0uvaurToFves9VufsxbHvEufrPVIyYyCLwwATznsynVCt1rr9LyhVLaqmqTJYH8H8ZKKI3iwxjBAPRgqzWmVWH8zqg1nXaoPZ5rJnp_77fkR3V3T0JuvPTzqQhcHH7FKgO0wr1ch2Hf_2yGH-tZuA0ZANmB11IaJNxs3h3xf5A1Gns2c</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Lorton, D.</creator><creator>Bellinger, D.L.</creator><creator>Felten, S.Y.</creator><creator>Felten, D.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>Substance P innervation of spleen in rats: Nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen</title><author>Lorton, D. ; Bellinger, D.L. ; Felten, S.Y. ; Felten, D.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-5e9cbe4937e02814d214accfaa8d8a8d0615d915daf814f2ab94fd7386abdbfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Lymphoid organs: ontogeny, organization, homing phenomenon</topic><topic>Macrophages</topic><topic>Male</topic><topic>Nerve Fibers - chemistry</topic><topic>Neuroimmunomodulation - physiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Strains</topic><topic>Spleen - cytology</topic><topic>Spleen - innervation</topic><topic>Spleen - ultrastructure</topic><topic>Substance P - analysis</topic><topic>Substance P - physiology</topic><topic>T-Lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorton, D.</creatorcontrib><creatorcontrib>Bellinger, D.L.</creatorcontrib><creatorcontrib>Felten, S.Y.</creatorcontrib><creatorcontrib>Felten, D.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorton, D.</au><au>Bellinger, D.L.</au><au>Felten, S.Y.</au><au>Felten, D.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substance P innervation of spleen in rats: Nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>5</volume><issue>1</issue><spage>29</spage><epage>40</epage><pages>29-40</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><coden>BBIMEW</coden><abstract>We investigated the distribution of SP+ nerve fibers in the spleen of adult male Fischer 344 rats. SP+ nerve fibers entered the spleen with the splenic artery in the hilar region, arborized along the venous sinuses, and extended from these larger plexuses into trabeculae and the surrounding red pulp. In the white pulp, SP+ nerve fibers were found in the marginal zone, and in the outer regions of the PALS among T lymphocytes. No SP+ nerve fibers were observed in association with the splenic capsule, the central arteries of the white pulp, or the follicles. SP levels in rat spleen were 5.7 ± 0.4 ng/g wet wt. On the basis of the present findings of SP presence in nerve fibers in the spleen, and published evidence for SP receptors on lymphocytes and macrophages, we suggest that SP derived from nerve fibers in the spleen can act as a neurotransmitter with cells of the immune system as targets. These SP nerve fibers may be an important neural link between the nervous system and the immune system and may participate in modulation of immune reactivity and inflammatory responses.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1712652</pmid><doi>10.1016/0889-1591(91)90005-U</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Lymphoid organs: ontogeny, organization, homing phenomenon Macrophages Male Nerve Fibers - chemistry Neuroimmunomodulation - physiology Rats Rats, Inbred F344 Rats, Inbred Strains Spleen - cytology Spleen - innervation Spleen - ultrastructure Substance P - analysis Substance P - physiology T-Lymphocytes |
| title | Substance P innervation of spleen in rats: Nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen |
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