Apoptosis in pancreatic allograft rejection - ultrastructural observations
Transplantation of pancreaticoduodenal allografts in the PVG.RT1c---PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma...
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| Veröffentlicht in: | Experimental pathology (1981) 1991, Vol.41 (4), p.219-224 |
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| container_end_page | 224 |
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| container_issue | 4 |
| container_start_page | 219 |
| container_title | Experimental pathology (1981) |
| container_volume | 41 |
| creator | KNOOP, M MCMAHON, R. F. T JONES, C. J. P HUTCHINSON, I. V |
| description | Transplantation of pancreaticoduodenal allografts in the PVG.RT1c---PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model. |
| doi_str_mv | 10.1016/S0232-1513(11)80099-X |
| format | Article |
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Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.</description><identifier>ISSN: 0232-1513</identifier><identifier>DOI: 10.1016/S0232-1513(11)80099-X</identifier><identifier>PMID: 2070844</identifier><language>eng</language><publisher>Limerick: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Cell Survival ; Graft Rejection ; Liver, biliary tract, pancreas, portal circulation, spleen ; Macrophages - pathology ; Macrophages - ultrastructure ; Male ; Medical sciences ; Microscopy, Electron ; Monocytes - pathology ; Monocytes - ultrastructure ; Pancreas - pathology ; Pancreas - ultrastructure ; Pancreas Transplantation - pathology ; Rats ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Graft Rejection</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Macrophages - pathology</subject><subject>Macrophages - ultrastructure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Monocytes - pathology</subject><subject>Monocytes - ultrastructure</subject><subject>Pancreas - pathology</subject><subject>Pancreas - ultrastructure</subject><subject>Pancreas Transplantation - pathology</subject><subject>Rats</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Transplantation, Homologous</topic><toplevel>online_resources</toplevel><creatorcontrib>KNOOP, M</creatorcontrib><creatorcontrib>MCMAHON, R. F. T</creatorcontrib><creatorcontrib>JONES, C. J. P</creatorcontrib><creatorcontrib>HUTCHINSON, I. V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental pathology (1981)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KNOOP, M</au><au>MCMAHON, R. F. T</au><au>JONES, C. J. P</au><au>HUTCHINSON, I. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis in pancreatic allograft rejection - ultrastructural observations</atitle><jtitle>Experimental pathology (1981)</jtitle><addtitle>Exp Pathol</addtitle><date>1991</date><risdate>1991</risdate><volume>41</volume><issue>4</issue><spage>219</spage><epage>224</epage><pages>219-224</pages><issn>0232-1513</issn><abstract>Transplantation of pancreaticoduodenal allografts in the PVG.RT1c---PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. 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| identifier | ISSN: 0232-1513 |
| ispartof | Experimental pathology (1981), 1991, Vol.41 (4), p.219-224 |
| issn | 0232-1513 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Cell Survival Graft Rejection Liver, biliary tract, pancreas, portal circulation, spleen Macrophages - pathology Macrophages - ultrastructure Male Medical sciences Microscopy, Electron Monocytes - pathology Monocytes - ultrastructure Pancreas - pathology Pancreas - ultrastructure Pancreas Transplantation - pathology Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Transplantation, Homologous |
| title | Apoptosis in pancreatic allograft rejection - ultrastructural observations |
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