Studies on Antiatherosclerotic Agents. Synthesis of 7-Ethoxycarbonyl-4-formyl-6, 8-dimethyl-1(2H)-phthalazinone Derivatives and Related Compounds

Derivatives of 7-ethoxycarbonyl-4-formyl-6, 8-dimethyl-1(2H)-phthalazinone and closely related compounds were synthesized using Wittig and epoxidation reactions. Ring opening amination of the epoxides were carried out using dimethylaluminum amide reagents under mild reaction conditions. β-Keto ester...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/03/25, Vol.39(3), pp.795-797
Hauptverfasser:	EGUCHI, Yukuo, SASAKI, Fujinori, TAKASHIMA, Yoshimi, NAKAJIMA, Masako, ISHIKAWA, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	7-ethoxycarbonyl-4-formyl-6, 8-dimethyl-1(2H)-phthalazinone Animals Arteriosclerosis - drug therapy Chemistry dimethylaluminum amide reagent epoxidation Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings inhibitory effect Organic chemistry Phthalazines - chemical synthesis Phthalazines - pharmacology platelet aggregation Platelet Aggregation Inhibitors - chemical synthesis Preparations and properties Rats rhodium(II) acetate synthesis Wittig reaction
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