Desciclovir permeation of the human erythrocyte membrane by nonfacilitated diffusion

The mechanism of transport of desciclovir (DCV)—a structural analogue and prodrug of acyclovir (ACV) which provides an improved oral bioavailability of ACV—was investigated in human erythrocytes with a “papaverine-stop” assay. DCV influx was nonconcentrative, linearly dependent on DCV concentration...

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Veröffentlicht in:	Biochemical pharmacology 1991-06, Vol.42 (1), p.147-152
Hauptverfasser:	Domin, Barbara A., Mahony, William B., Zimmerman, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - analogs & derivatives Acyclovir - metabolism Adenine - metabolism Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Membrane Permeability - drug effects Diffusion Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Humans Idoxuridine - metabolism Kinetics Medical sciences Papaverine - pharmacology Pharmacology. Drug treatments
Online-Zugang:	Volltext
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