The Pharmacology and Clinical Use of Methotrexate

METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer. 1 It has also become an import...

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Veröffentlicht in:	The New England journal of medicine 1983-11, Vol.309 (18), p.1094-1104
Hauptverfasser:	Jolivet, Jacques, Cowan, Kenneth H, Curt, Gregory A, Clendeninn, Neil J, Chabner, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Administration, Oral Animals Antineoplastic agents Biological and medical sciences Biological Transport - drug effects Cancer Cancer therapies Cell division Central Nervous System - metabolism Chemotherapy Dihydrofolate reductase Drug dosages Drug Resistance Enzymes Folic Acid - metabolism Folic Acid Antagonists Gene Amplification Head and Neck Neoplasms - drug therapy Humans Kinetics Leucovorin - administration & dosage Leukemia, Lymphoid - drug therapy Lung Neoplasms - drug therapy Medical sciences Methotrexate - metabolism Methotrexate - pharmacology Methotrexate - therapeutic use Neoplasms - drug therapy Neoplasms - enzymology Osteoma, Osteoid - drug therapy Pharmacology. Drug treatments Thymidylate Synthase - metabolism Tissue Distribution Vitamin B
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