Dual Effects of Ascorbate on Serotonin and Spiperone Binding in Rat Cortical Membranes

: Ascorbate‐induced lipid peroxidation, as measured by malonyldialdehyde (MDA) production, caused irreversible decreases in Bmax of both [3H]5‐HT and [3H]spiperone binding. CaCl2 (4 mM) inhibited ascorbateinduced MDA formation at ascorbate concentrations >0.57 mM, but not at ≤0.57 mM. Under the s...

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Veröffentlicht in:	Journal of neurochemistry 1983-01, Vol.41 (5), p.1429-1438
Hauptverfasser:	Muakkassah‐Kelly, S. F., Andresen, J. W., Shih, J. C., Hochstein, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptamine Animals Ascorbate ascorbic acid Ascorbic Acid - pharmacology Biological and medical sciences Butylated Hydroxytoluene - pharmacology Butyrophenones - metabolism Calcium Chloride - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism cortex dopamine Edetic Acid - pharmacology Lipid peroxidation Lipid Peroxides - metabolism Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Rats, Inbred Strains Reducing agents Serotonin - metabolism Serotonin binding sites Spiperone - metabolism
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