Impairment of Ascorbic Acid Synthesis in Liver Extracts of Magnesium-Deficient Rats
The effect of feeding a magnesium (Mg)-deficient diet for 9–34 days to weanling and young male rats on urinary and tissue ascorbate levels were studied. The concentrations of ascorbic acid in the liver and kidney were significantly reduced in the rats receiving a Mg-deficient diet as compared to tho...
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| Veröffentlicht in: | The Journal of nutrition 1983-10, Vol.113 (10), p.2041-2047 |
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| container_title | The Journal of nutrition |
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| creator | Hsu, Jeng M. Smith, J. Cecil Yunice, A.A. Kepford, G. |
| description | The effect of feeding a magnesium (Mg)-deficient diet for 9–34 days to weanling and young male rats on urinary and tissue ascorbate levels were studied. The concentrations of ascorbic acid in the liver and kidney were significantly reduced in the rats receiving a Mg-deficient diet as compared to those receiving a Mg-supplemented diet. The response to trichloro-2-methyl-2-propanol stimulation of urinary ascorbic acid was found to be considerably suppressed by dietary deficiency of Mg, suggesting that the decrease was not due to feed intake. In in vitro studies, the enzymatic synthesis of the vitamin from glucuronolactone or gulonolactone by liver extracts from Mg-deficient rats was significantly decreased as compared with Mg-supplemented rats. These results suggest that Mg-deficient rats have a reduced capacity to synthesize ascorbate which in turn produces a decrease in ascorbic acid concentrations in the liver. |
| doi_str_mv | 10.1093/jn/113.10.2041 |
| format | Article |
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Cecil ; Yunice, A.A. ; Kepford, G.</creator><creatorcontrib>Hsu, Jeng M. ; Smith, J. Cecil ; Yunice, A.A. ; Kepford, G.</creatorcontrib><description>The effect of feeding a magnesium (Mg)-deficient diet for 9–34 days to weanling and young male rats on urinary and tissue ascorbate levels were studied. The concentrations of ascorbic acid in the liver and kidney were significantly reduced in the rats receiving a Mg-deficient diet as compared to those receiving a Mg-supplemented diet. The response to trichloro-2-methyl-2-propanol stimulation of urinary ascorbic acid was found to be considerably suppressed by dietary deficiency of Mg, suggesting that the decrease was not due to feed intake. In in vitro studies, the enzymatic synthesis of the vitamin from glucuronolactone or gulonolactone by liver extracts from Mg-deficient rats was significantly decreased as compared with Mg-supplemented rats. These results suggest that Mg-deficient rats have a reduced capacity to synthesize ascorbate which in turn produces a decrease in ascorbic acid concentrations in the liver.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/113.10.2041</identifier><identifier>PMID: 6619983</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; ascorbic acid ; Ascorbic Acid - biosynthesis ; Ascorbic Acid - urine ; Biological and medical sciences ; Calcium - blood ; Chlorobutanol - pharmacology ; enzymatic synthesis ; Enzymes. Coenzymes. Vitamins. Pigments ; Fundamental and applied biological sciences. Psychology ; Kidney - metabolism ; Liver - metabolism ; Magnesium - blood ; magnesium deficiency ; Magnesium Deficiency - metabolism ; Male ; Metabolisms and neurohumoral controls ; Rats ; Rats, Inbred Strains ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1983-10, Vol.113 (10), p.2041-2047</ispartof><rights>1983 American Society for Nutrition.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-4b459d226571df4b64d05f324255188fb824e5dcc667ce77eac88b893cc493c63</citedby><cites>FETCH-LOGICAL-c432t-4b459d226571df4b64d05f324255188fb824e5dcc667ce77eac88b893cc493c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9474732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6619983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Jeng M.</creatorcontrib><creatorcontrib>Smith, J. Cecil</creatorcontrib><creatorcontrib>Yunice, A.A.</creatorcontrib><creatorcontrib>Kepford, G.</creatorcontrib><title>Impairment of Ascorbic Acid Synthesis in Liver Extracts of Magnesium-Deficient Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effect of feeding a magnesium (Mg)-deficient diet for 9–34 days to weanling and young male rats on urinary and tissue ascorbate levels were studied. The concentrations of ascorbic acid in the liver and kidney were significantly reduced in the rats receiving a Mg-deficient diet as compared to those receiving a Mg-supplemented diet. The response to trichloro-2-methyl-2-propanol stimulation of urinary ascorbic acid was found to be considerably suppressed by dietary deficiency of Mg, suggesting that the decrease was not due to feed intake. In in vitro studies, the enzymatic synthesis of the vitamin from glucuronolactone or gulonolactone by liver extracts from Mg-deficient rats was significantly decreased as compared with Mg-supplemented rats. These results suggest that Mg-deficient rats have a reduced capacity to synthesize ascorbate which in turn produces a decrease in ascorbic acid concentrations in the liver.</description><subject>Animals</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - biosynthesis</subject><subject>Ascorbic Acid - urine</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Chlorobutanol - pharmacology</subject><subject>enzymatic synthesis</subject><subject>Enzymes. Coenzymes. Vitamins. Pigments</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Magnesium - blood</subject><subject>magnesium deficiency</subject><subject>Magnesium Deficiency - metabolism</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtv2zAURokiQeq6WbsF1VB0k82XKGo0HLc14KBAncwEdXWZ0LAkh5SD-t-Xgo1sXfjAd_hd4hDyhdEZo5WY77o5YyKdZ5xK9oFMWCFZrhilV2RCKee5YEp9JJ9i3FFKmaz0DblRilWVFhOyXbcH60OL3ZD1LltE6EPtIVuAb7LtqRteMPqY-S7b-DcM2ervECwMcYQf7HOX0mOb36Pz4MeOP3aIn8m1s_uIt5d9Sp5-rB6Xv_LN75_r5WKTgxR8yGUti6rhXBUla5yslWxo4QSXvCiY1q7WXGLRAChVApYlWtC61pUAkGlRYkq-n3sPoX89YhxM6yPgfm877I_RaKpKKTRP4OwMQuhjDOjMIfjWhpNh1IwWza4zyeJ4HS2mB3eX5mPdYvOOX7Sl_NsltxHs3gXbgY_vWCVLWYpx7tcz5mxv7HNIyNOWUyYoV5wXVZkIfSYweXrzGEwcPQI2PiAMpun9__74D_TZlQo</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>Hsu, Jeng M.</creator><creator>Smith, J. Cecil</creator><creator>Yunice, A.A.</creator><creator>Kepford, G.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198310</creationdate><title>Impairment of Ascorbic Acid Synthesis in Liver Extracts of Magnesium-Deficient Rats</title><author>Hsu, Jeng M. ; Smith, J. Cecil ; Yunice, A.A. ; Kepford, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-4b459d226571df4b64d05f324255188fb824e5dcc667ce77eac88b893cc493c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - biosynthesis</topic><topic>Ascorbic Acid - urine</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Chlorobutanol - pharmacology</topic><topic>enzymatic synthesis</topic><topic>Enzymes. Coenzymes. Vitamins. Pigments</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Magnesium - blood</topic><topic>magnesium deficiency</topic><topic>Magnesium Deficiency - metabolism</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Jeng M.</creatorcontrib><creatorcontrib>Smith, J. Cecil</creatorcontrib><creatorcontrib>Yunice, A.A.</creatorcontrib><creatorcontrib>Kepford, G.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Jeng M.</au><au>Smith, J. Cecil</au><au>Yunice, A.A.</au><au>Kepford, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impairment of Ascorbic Acid Synthesis in Liver Extracts of Magnesium-Deficient Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1983-10</date><risdate>1983</risdate><volume>113</volume><issue>10</issue><spage>2041</spage><epage>2047</epage><pages>2041-2047</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effect of feeding a magnesium (Mg)-deficient diet for 9–34 days to weanling and young male rats on urinary and tissue ascorbate levels were studied. The concentrations of ascorbic acid in the liver and kidney were significantly reduced in the rats receiving a Mg-deficient diet as compared to those receiving a Mg-supplemented diet. The response to trichloro-2-methyl-2-propanol stimulation of urinary ascorbic acid was found to be considerably suppressed by dietary deficiency of Mg, suggesting that the decrease was not due to feed intake. In in vitro studies, the enzymatic synthesis of the vitamin from glucuronolactone or gulonolactone by liver extracts from Mg-deficient rats was significantly decreased as compared with Mg-supplemented rats. These results suggest that Mg-deficient rats have a reduced capacity to synthesize ascorbate which in turn produces a decrease in ascorbic acid concentrations in the liver.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6619983</pmid><doi>10.1093/jn/113.10.2041</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals ascorbic acid Ascorbic Acid - biosynthesis Ascorbic Acid - urine Biological and medical sciences Calcium - blood Chlorobutanol - pharmacology enzymatic synthesis Enzymes. Coenzymes. Vitamins. Pigments Fundamental and applied biological sciences. Psychology Kidney - metabolism Liver - metabolism Magnesium - blood magnesium deficiency Magnesium Deficiency - metabolism Male Metabolisms and neurohumoral controls Rats Rats, Inbred Strains Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Impairment of Ascorbic Acid Synthesis in Liver Extracts of Magnesium-Deficient Rats |
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