Moderate and severe protein energy malnutrition in childhood: Effects on jejunal mucosal morphology and disaccharidase activities
Extract: The enzymatic activities of maltase, sucrase, and lactase were determined in jejunal biopsies obtained from 24 children with gastrointestinal symptoms and different degrees of protein energy malnutrition (PEM) to see if these differences were related to the extent of malnutrition or to conc...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1983-01, Vol.2 (3), p.459-464 |
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| container_end_page | 464 |
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| container_issue | 3 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Romer, Hans Urbach, Raquel Gomez, Maria A Lopez, Amadita Perozo-Ruggeri, Gladys Vegas, Maria Enriqueta |
| description | Extract: The enzymatic activities of maltase, sucrase, and lactase were determined in jejunal biopsies obtained from 24 children with gastrointestinal symptoms and different degrees of protein energy malnutrition (PEM) to see if these differences were related to the extent of malnutrition or to concomitant small intestinal mucosal injury. Even in patients with moderate PEM, lactase activities were significantly lower than control values. The decrease in lactase activity seemed to depend on the severity of malnutrition. In contrast, maltase and sucrase activities were decreased only in second and third degrees of PEM, while no significant changes were observed in first degree and marasmic kwashiorkor. Histologically, all children with PEM had grade I-II mucosal injury, which did not correlate with the degree of malnutrition. These results indicate that PEM affects each of the disaccharidases of the jejunal mucosa differently, with lactase being most sensitive to PEM and most-closely reflecting the degree of PEM. In contrast, morphological changes showed no correlation with the degree of PEM. (author/wz) |
| doi_str_mv | 10.1002/j.1536-4801.1983.tb08527.x |
| format | Article |
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Even in patients with moderate PEM, lactase activities were significantly lower than control values. The decrease in lactase activity seemed to depend on the severity of malnutrition. In contrast, maltase and sucrase activities were decreased only in second and third degrees of PEM, while no significant changes were observed in first degree and marasmic kwashiorkor. Histologically, all children with PEM had grade I-II mucosal injury, which did not correlate with the degree of malnutrition. These results indicate that PEM affects each of the disaccharidases of the jejunal mucosa differently, with lactase being most sensitive to PEM and most-closely reflecting the degree of PEM. In contrast, morphological changes showed no correlation with the degree of PEM. (author/wz)</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1983.tb08527.x</identifier><identifier>PMID: 6413668</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>alpha-Glucosidases - metabolism ; analytical methods ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Biopsy ; carbohydrate metabolism ; Child, Preschool ; children ; clinical trials ; Disaccharidases - metabolism ; enzyme deficiencies ; Female ; Humans ; Infant ; Intestinal Mucosa - enzymology ; Intestinal Mucosa - pathology ; Jejunum - pathology ; Male ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; protein energy malnutrition ; Protein-Energy Malnutrition - enzymology ; Protein-Energy Malnutrition - pathology ; Sucrase - metabolism</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1983-01, Vol.2 (3), p.459-464</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9359245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6413668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romer, Hans</creatorcontrib><creatorcontrib>Urbach, Raquel</creatorcontrib><creatorcontrib>Gomez, Maria A</creatorcontrib><creatorcontrib>Lopez, Amadita</creatorcontrib><creatorcontrib>Perozo-Ruggeri, Gladys</creatorcontrib><creatorcontrib>Vegas, Maria Enriqueta</creatorcontrib><title>Moderate and severe protein energy malnutrition in childhood: Effects on jejunal mucosal morphology and disaccharidase activities</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Extract: The enzymatic activities of maltase, sucrase, and lactase were determined in jejunal biopsies obtained from 24 children with gastrointestinal symptoms and different degrees of protein energy malnutrition (PEM) to see if these differences were related to the extent of malnutrition or to concomitant small intestinal mucosal injury. Even in patients with moderate PEM, lactase activities were significantly lower than control values. The decrease in lactase activity seemed to depend on the severity of malnutrition. In contrast, maltase and sucrase activities were decreased only in second and third degrees of PEM, while no significant changes were observed in first degree and marasmic kwashiorkor. Histologically, all children with PEM had grade I-II mucosal injury, which did not correlate with the degree of malnutrition. These results indicate that PEM affects each of the disaccharidases of the jejunal mucosa differently, with lactase being most sensitive to PEM and most-closely reflecting the degree of PEM. In contrast, morphological changes showed no correlation with the degree of PEM. (author/wz)</description><subject>alpha-Glucosidases - metabolism</subject><subject>analytical methods</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>carbohydrate metabolism</subject><subject>Child, Preschool</subject><subject>children</subject><subject>clinical trials</subject><subject>Disaccharidases - metabolism</subject><subject>enzyme deficiencies</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Jejunum - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>protein energy malnutrition</subject><subject>Protein-Energy Malnutrition - enzymology</subject><subject>Protein-Energy Malnutrition - pathology</subject><subject>Sucrase - metabolism</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtv1TAQhSMEKpfCT0BECLFLGNtJnHRXVeUhFbGAri3HGTcOvvHFdvpY8s9xuNFdjTTnzBnP5yx7T6AkAPTTVJKaNUXVAilJ17Iy9tDWlJePz7LdSXqe7YByXlBCmpfZqxAmAOBVDWfZWVMR1jTtLvv73Q3oZcRczkMe8B495gfvIpo5xxn93VO-l3ZeojfRuDlPbTUaO4zODRf5tdaoYsiTMOG0zNLm-0W5sFbnD6OzLgWs0YMJUqlRejPIkLapaO5TIobX2QstbcA3Wz3Pbj9f_7r6Wtz8-PLt6vKmULTlpKB0aLHVfVW3UHWy1RV0jeok6SrF-76uGAdWd4xKjQ3rudYqMeiB6Z5wSQk7zz4ec9N1fxYMUexNUGitnNEtQbTQcEL-Gy-ORuVdCB61OHizl_5JEBArfzGJFbJYIYuVv9j4i8c0_HbbsvR7HE6jG_Ckf9h0GZS02stZmXCydekEWtXJVh1tD85G9OG3XR7QixGljaNI_wg14U2xLgcKDIrUIevT3x3HtHRC3vmUfPuTAkmmmtYNdOwfSj6qiw</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Romer, Hans</creator><creator>Urbach, Raquel</creator><creator>Gomez, Maria A</creator><creator>Lopez, Amadita</creator><creator>Perozo-Ruggeri, Gladys</creator><creator>Vegas, Maria Enriqueta</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Moderate and severe protein energy malnutrition in childhood: Effects on jejunal mucosal morphology and disaccharidase activities</title><author>Romer, Hans ; Urbach, Raquel ; Gomez, Maria A ; Lopez, Amadita ; Perozo-Ruggeri, Gladys ; Vegas, Maria Enriqueta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2871-22d8e8fb458049a8f4096c9a194c7bb5437035932afe63b7ffc801b03fb17a213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>alpha-Glucosidases - metabolism</topic><topic>analytical methods</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>carbohydrate metabolism</topic><topic>Child, Preschool</topic><topic>children</topic><topic>clinical trials</topic><topic>Disaccharidases - metabolism</topic><topic>enzyme deficiencies</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Jejunum - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>protein energy malnutrition</topic><topic>Protein-Energy Malnutrition - enzymology</topic><topic>Protein-Energy Malnutrition - pathology</topic><topic>Sucrase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romer, Hans</creatorcontrib><creatorcontrib>Urbach, Raquel</creatorcontrib><creatorcontrib>Gomez, Maria A</creatorcontrib><creatorcontrib>Lopez, Amadita</creatorcontrib><creatorcontrib>Perozo-Ruggeri, Gladys</creatorcontrib><creatorcontrib>Vegas, Maria Enriqueta</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romer, Hans</au><au>Urbach, Raquel</au><au>Gomez, Maria A</au><au>Lopez, Amadita</au><au>Perozo-Ruggeri, Gladys</au><au>Vegas, Maria Enriqueta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate and severe protein energy malnutrition in childhood: Effects on jejunal mucosal morphology and disaccharidase activities</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>2</volume><issue>3</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Extract: The enzymatic activities of maltase, sucrase, and lactase were determined in jejunal biopsies obtained from 24 children with gastrointestinal symptoms and different degrees of protein energy malnutrition (PEM) to see if these differences were related to the extent of malnutrition or to concomitant small intestinal mucosal injury. Even in patients with moderate PEM, lactase activities were significantly lower than control values. The decrease in lactase activity seemed to depend on the severity of malnutrition. In contrast, maltase and sucrase activities were decreased only in second and third degrees of PEM, while no significant changes were observed in first degree and marasmic kwashiorkor. Histologically, all children with PEM had grade I-II mucosal injury, which did not correlate with the degree of malnutrition. These results indicate that PEM affects each of the disaccharidases of the jejunal mucosa differently, with lactase being most sensitive to PEM and most-closely reflecting the degree of PEM. In contrast, morphological changes showed no correlation with the degree of PEM. (author/wz)</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>6413668</pmid><doi>10.1002/j.1536-4801.1983.tb08527.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 1983-01, Vol.2 (3), p.459-464 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | alpha-Glucosidases - metabolism analytical methods beta-Galactosidase - metabolism Biological and medical sciences Biopsy carbohydrate metabolism Child, Preschool children clinical trials Disaccharidases - metabolism enzyme deficiencies Female Humans Infant Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Jejunum - pathology Male Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) protein energy malnutrition Protein-Energy Malnutrition - enzymology Protein-Energy Malnutrition - pathology Sucrase - metabolism |
| title | Moderate and severe protein energy malnutrition in childhood: Effects on jejunal mucosal morphology and disaccharidase activities |
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