Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently
Intracerebroventricular injection of pertussis toxin (PTX, 1 μg/rat) six days before the hot plate test abolished analgesia induced by central morphine. The toxin did not affect analgesia evoked by central neurotensin or ASU 1–7 eel calcitonin. PTX pretreatment also attenuated footshock-induced anal...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1991-03, Vol.38 (3), p.569-573 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Parolaro, Daniela Massi, Paola Patrini, Gabriela Rubino, Tiziana Parenti, Marco Gori, Enzo |
| description | Intracerebroventricular injection of pertussis toxin (PTX, 1 μg/rat) six days before the hot plate test abolished analgesia induced by central morphine. The toxin did not affect analgesia evoked by central neurotensin or ASU 1–7 eel calcitonin. PTX pretreatment also attenuated footshock-induced analgesia (FSIA) delivered to all four paws. When the shock was restricted to the front paws, PTX consistently lowered postshock tail flick latencies, but did not reduce analgesia resulting from shock delivered to the hind paws. It thus appears that PTX-sensitive G-proteins are an essential transduction step needed to initiate the molecular events underlying opiate analgesia evoked by either morphine or shock. In contrast, the signal transduction mechanism subsequent to the stimulation of neurotensin or calcitonin receptors, and to the nonopiate FSIA, appears not to involve PTX-sensitive G-proteins. |
| doi_str_mv | 10.1016/0091-3057(91)90015-T |
| format | Article |
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In contrast, the signal transduction mechanism subsequent to the stimulation of neurotensin or calcitonin receptors, and to the nonopiate FSIA, appears not to involve PTX-sensitive G-proteins.</description><subject>Analgesia</subject><subject>Animals</subject><subject>ASU 1–7 eel calcitonin</subject><subject>Calcitonin - analogs & derivatives</subject><subject>Calcitonin - antagonists & inhibitors</subject><subject>Electroshock</subject><subject>Foot shock-induced analgesia</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Microinjections</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Neurotensin</subject><subject>Neurotensin - antagonists & inhibitors</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Pertussis Toxin</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stress, Physiological - physiopathology</subject><subject>Time Factors</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQha0KRBfaf9BKOSF6CMwkTpxcKqEVpUhIcNhea3ntMTLKJluPg-Df19tdcexpRvPem9F8QnxBuETA9gqgx7KGRl30-K0HwKZcfRAL7FRdNqjUkVi8Wz6KU-ZnAJBVq07ESQVth321EL8fKaaZOXCRptcwFttIKZJJGxpTYbwnm7iYtsEkuhqncd8VZnQFZx9zGUY3W3J5ZIYn4mAKF3Is5vzw9kkcezMwfT7UM_Hrx81q-bO8f7i9W17fl7ZuVCpRoSfjnO-oarxt0UvfIHT9ukFrjPSuM66qJLXe1ZI8VGuFa4BKetX7ztZn4ny_dxunPzNx0pvAlobBjDTNrDtoFaCU2Sj3Rhsn5kheb2PYmPimEfQOq94x0ztmOtd_WPUqx74e9s_rDbn30IFj1r_vdcpPvgSKmm2gMXMJMRPUbgr_P_AXxt2J4w</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Parolaro, Daniela</creator><creator>Massi, Paola</creator><creator>Patrini, Gabriela</creator><creator>Rubino, Tiziana</creator><creator>Parenti, Marco</creator><creator>Gori, Enzo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently</title><author>Parolaro, Daniela ; Massi, Paola ; Patrini, Gabriela ; Rubino, Tiziana ; Parenti, Marco ; Gori, Enzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-171feaddf8e25fc61f4f51089b51caa4fd8ad224e6fd34ef02b71b0024f79f8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>ASU 1–7 eel calcitonin</topic><topic>Calcitonin - analogs & derivatives</topic><topic>Calcitonin - antagonists & inhibitors</topic><topic>Electroshock</topic><topic>Foot shock-induced analgesia</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Microinjections</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Neurotensin</topic><topic>Neurotensin - antagonists & inhibitors</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Pertussis Toxin</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stress, Physiological - physiopathology</topic><topic>Time Factors</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parolaro, Daniela</creatorcontrib><creatorcontrib>Massi, Paola</creatorcontrib><creatorcontrib>Patrini, Gabriela</creatorcontrib><creatorcontrib>Rubino, Tiziana</creatorcontrib><creatorcontrib>Parenti, Marco</creatorcontrib><creatorcontrib>Gori, Enzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parolaro, Daniela</au><au>Massi, Paola</au><au>Patrini, Gabriela</au><au>Rubino, Tiziana</au><au>Parenti, Marco</au><au>Gori, Enzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>38</volume><issue>3</issue><spage>569</spage><epage>573</epage><pages>569-573</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Intracerebroventricular injection of pertussis toxin (PTX, 1 μg/rat) six days before the hot plate test abolished analgesia induced by central morphine. The toxin did not affect analgesia evoked by central neurotensin or ASU 1–7 eel calcitonin. PTX pretreatment also attenuated footshock-induced analgesia (FSIA) delivered to all four paws. When the shock was restricted to the front paws, PTX consistently lowered postshock tail flick latencies, but did not reduce analgesia resulting from shock delivered to the hind paws. It thus appears that PTX-sensitive G-proteins are an essential transduction step needed to initiate the molecular events underlying opiate analgesia evoked by either morphine or shock. In contrast, the signal transduction mechanism subsequent to the stimulation of neurotensin or calcitonin receptors, and to the nonopiate FSIA, appears not to involve PTX-sensitive G-proteins.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2068192</pmid><doi>10.1016/0091-3057(91)90015-T</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1991-03, Vol.38 (3), p.569-573 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analgesia Animals ASU 1–7 eel calcitonin Calcitonin - analogs & derivatives Calcitonin - antagonists & inhibitors Electroshock Foot shock-induced analgesia Injections, Intraventricular Male Microinjections Morphine - antagonists & inhibitors Neurotensin Neurotensin - antagonists & inhibitors Pain - physiopathology Pain Measurement Pertussis Toxin Rats Rats, Inbred Strains Stress, Physiological - physiopathology Time Factors Virulence Factors, Bordetella - pharmacology |
| title | Pertussis toxin pretreatment affects opiate/nonopiate and stress-induced analgesia differently |
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