Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats
: Changes in brain amino acid uptake and metabolism have been proposed as a possible etiological factor in hepatic encephalopathy. By use of a brain dialysis technique (a thin tube implanted in the brain of the living animal), the extracellular amino acid concentrations in the striatum of portacaval...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 1983-04, Vol.41 (4), p.1046-1051 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1051 |
|---|---|
| container_issue | 4 |
| container_start_page | 1046 |
| container_title | Journal of neurochemistry |
| container_volume | 41 |
| creator | Tossman, Ulf Eriksson, Siw Delin, Anders Hagenfeldt, Lars Law, David Ungerstedt, Urban |
| description | : Changes in brain amino acid uptake and metabolism have been proposed as a possible etiological factor in hepatic encephalopathy. By use of a brain dialysis technique (a thin tube implanted in the brain of the living animal), the extracellular amino acid concentrations in the striatum of portacaval (PC)‐shunted and shamoperated rats were measured. Leucine, phenylalanine, methionine, and glutamine were increased two‐ to sixfold in the PC‐shunted rats, whilst no changes were seen for GABA, valine, glutamate, or isoleucine, confirming previous reports. Aspartate levels were 350% higher in the PC‐shunted rats, and this rise, as well as that of phenylalanine, was significantly correlated with the lower motor activity observed in the PC‐shunted rats, suggesting a possible importance of these amino acids in the etiology of hepatic encephalopathy. The amino acid concentrations measured in whole blood demonstrated the well‐known pattern of low levels of branched‐chain amino acids and increased concentrations of phenylalanine, glutamine, and histidine. |
| doi_str_mv | 10.1111/j.1471-4159.1983.tb09049.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80669794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>13812533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4966-e6ea7df92fd44576023db0327cc77ba00d688c5c0d25d6cd306ac2d6426bf8973</originalsourceid><addsrcrecordid>eNqVkF2L1DAUhoMo6-zqTxCKiHetJx9NGm9kHFddWV3x4zqcJilm6LS7Sas7_94MU-ZWzM2BvM97Eh5CnlOoaD6vthUVipaC1rqiuuHV1IIGoav7B2R1ih6SFQBjJQfBHpPzlLYAVApJz8iZlLknxIrcvI0YhmK9C8NYrG1wqfjsMc3Ru6LdF1fDFNH66NuIffEuYL9PIRW58XWME1r8na-__5qHKfPfcEpPyKMO--SfLvOC_Hx_-WPzsby--XC1WV-XVmgpSy89Ktdp1jkhaiWBcdcCZ8papVoEcLJpbG3BsdpJ6zhItMxJwWTbNVrxC_LyuPc2jnezT5PZhWR93-PgxzmZBqTUSot_gpQ3lNWcZ_D1EbRxTCn6ztzGsMO4NxTMQbvZmoNbc3BrDtrNot3c5_Kz5ZW53Xl3qi6ec_5iyTFZ7LuIgw3phGnBqKppxt4csT-h9_v_-ID59GVDQUj-F6jQnoY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13812533</pqid></control><display><type>article</type><title>Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Tossman, Ulf ; Eriksson, Siw ; Delin, Anders ; Hagenfeldt, Lars ; Law, David ; Ungerstedt, Urban</creator><creatorcontrib>Tossman, Ulf ; Eriksson, Siw ; Delin, Anders ; Hagenfeldt, Lars ; Law, David ; Ungerstedt, Urban</creatorcontrib><description>: Changes in brain amino acid uptake and metabolism have been proposed as a possible etiological factor in hepatic encephalopathy. By use of a brain dialysis technique (a thin tube implanted in the brain of the living animal), the extracellular amino acid concentrations in the striatum of portacaval (PC)‐shunted and shamoperated rats were measured. Leucine, phenylalanine, methionine, and glutamine were increased two‐ to sixfold in the PC‐shunted rats, whilst no changes were seen for GABA, valine, glutamate, or isoleucine, confirming previous reports. Aspartate levels were 350% higher in the PC‐shunted rats, and this rise, as well as that of phenylalanine, was significantly correlated with the lower motor activity observed in the PC‐shunted rats, suggesting a possible importance of these amino acids in the etiology of hepatic encephalopathy. The amino acid concentrations measured in whole blood demonstrated the well‐known pattern of low levels of branched‐chain amino acids and increased concentrations of phenylalanine, glutamine, and histidine.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1983.tb09049.x</identifier><identifier>PMID: 6619844</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino acids ; Amino Acids - blood ; Amino Acids - metabolism ; Animals ; Biological and medical sciences ; Brain - metabolism ; Brain dialysis ; Dialysis ; Extracellular ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatic encephalopathy ; Hepatic Encephalopathy - metabolism ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Malformations ; Medical sciences ; Motor Activity ; Portacaval Shunt, Surgical ; Rats ; Rats, Inbred Strains</subject><ispartof>Journal of neurochemistry, 1983-04, Vol.41 (4), p.1046-1051</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4966-e6ea7df92fd44576023db0327cc77ba00d688c5c0d25d6cd306ac2d6426bf8973</citedby><cites>FETCH-LOGICAL-c4966-e6ea7df92fd44576023db0327cc77ba00d688c5c0d25d6cd306ac2d6426bf8973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1983.tb09049.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1983.tb09049.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9421751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6619844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tossman, Ulf</creatorcontrib><creatorcontrib>Eriksson, Siw</creatorcontrib><creatorcontrib>Delin, Anders</creatorcontrib><creatorcontrib>Hagenfeldt, Lars</creatorcontrib><creatorcontrib>Law, David</creatorcontrib><creatorcontrib>Ungerstedt, Urban</creatorcontrib><title>Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Changes in brain amino acid uptake and metabolism have been proposed as a possible etiological factor in hepatic encephalopathy. By use of a brain dialysis technique (a thin tube implanted in the brain of the living animal), the extracellular amino acid concentrations in the striatum of portacaval (PC)‐shunted and shamoperated rats were measured. Leucine, phenylalanine, methionine, and glutamine were increased two‐ to sixfold in the PC‐shunted rats, whilst no changes were seen for GABA, valine, glutamate, or isoleucine, confirming previous reports. Aspartate levels were 350% higher in the PC‐shunted rats, and this rise, as well as that of phenylalanine, was significantly correlated with the lower motor activity observed in the PC‐shunted rats, suggesting a possible importance of these amino acids in the etiology of hepatic encephalopathy. The amino acid concentrations measured in whole blood demonstrated the well‐known pattern of low levels of branched‐chain amino acids and increased concentrations of phenylalanine, glutamine, and histidine.</description><subject>Amino acids</subject><subject>Amino Acids - blood</subject><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain dialysis</subject><subject>Dialysis</subject><subject>Extracellular</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatic encephalopathy</subject><subject>Hepatic Encephalopathy - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Malformations</subject><subject>Medical sciences</subject><subject>Motor Activity</subject><subject>Portacaval Shunt, Surgical</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2L1DAUhoMo6-zqTxCKiHetJx9NGm9kHFddWV3x4zqcJilm6LS7Sas7_94MU-ZWzM2BvM97Eh5CnlOoaD6vthUVipaC1rqiuuHV1IIGoav7B2R1ih6SFQBjJQfBHpPzlLYAVApJz8iZlLknxIrcvI0YhmK9C8NYrG1wqfjsMc3Ru6LdF1fDFNH66NuIffEuYL9PIRW58XWME1r8na-__5qHKfPfcEpPyKMO--SfLvOC_Hx_-WPzsby--XC1WV-XVmgpSy89Ktdp1jkhaiWBcdcCZ8papVoEcLJpbG3BsdpJ6zhItMxJwWTbNVrxC_LyuPc2jnezT5PZhWR93-PgxzmZBqTUSot_gpQ3lNWcZ_D1EbRxTCn6ztzGsMO4NxTMQbvZmoNbc3BrDtrNot3c5_Kz5ZW53Xl3qi6ec_5iyTFZ7LuIgw3phGnBqKppxt4csT-h9_v_-ID59GVDQUj-F6jQnoY</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Tossman, Ulf</creator><creator>Eriksson, Siw</creator><creator>Delin, Anders</creator><creator>Hagenfeldt, Lars</creator><creator>Law, David</creator><creator>Ungerstedt, Urban</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats</title><author>Tossman, Ulf ; Eriksson, Siw ; Delin, Anders ; Hagenfeldt, Lars ; Law, David ; Ungerstedt, Urban</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4966-e6ea7df92fd44576023db0327cc77ba00d688c5c0d25d6cd306ac2d6426bf8973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Amino acids</topic><topic>Amino Acids - blood</topic><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain dialysis</topic><topic>Dialysis</topic><topic>Extracellular</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatic encephalopathy</topic><topic>Hepatic Encephalopathy - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Malformations</topic><topic>Medical sciences</topic><topic>Motor Activity</topic><topic>Portacaval Shunt, Surgical</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tossman, Ulf</creatorcontrib><creatorcontrib>Eriksson, Siw</creatorcontrib><creatorcontrib>Delin, Anders</creatorcontrib><creatorcontrib>Hagenfeldt, Lars</creatorcontrib><creatorcontrib>Law, David</creatorcontrib><creatorcontrib>Ungerstedt, Urban</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tossman, Ulf</au><au>Eriksson, Siw</au><au>Delin, Anders</au><au>Hagenfeldt, Lars</au><au>Law, David</au><au>Ungerstedt, Urban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1983-04</date><risdate>1983</risdate><volume>41</volume><issue>4</issue><spage>1046</spage><epage>1051</epage><pages>1046-1051</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Changes in brain amino acid uptake and metabolism have been proposed as a possible etiological factor in hepatic encephalopathy. By use of a brain dialysis technique (a thin tube implanted in the brain of the living animal), the extracellular amino acid concentrations in the striatum of portacaval (PC)‐shunted and shamoperated rats were measured. Leucine, phenylalanine, methionine, and glutamine were increased two‐ to sixfold in the PC‐shunted rats, whilst no changes were seen for GABA, valine, glutamate, or isoleucine, confirming previous reports. Aspartate levels were 350% higher in the PC‐shunted rats, and this rise, as well as that of phenylalanine, was significantly correlated with the lower motor activity observed in the PC‐shunted rats, suggesting a possible importance of these amino acids in the etiology of hepatic encephalopathy. The amino acid concentrations measured in whole blood demonstrated the well‐known pattern of low levels of branched‐chain amino acids and increased concentrations of phenylalanine, glutamine, and histidine.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6619844</pmid><doi>10.1111/j.1471-4159.1983.tb09049.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1983-04, Vol.41 (4), p.1046-1051 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80669794 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Amino acids Amino Acids - blood Amino Acids - metabolism Animals Biological and medical sciences Brain - metabolism Brain dialysis Dialysis Extracellular Gastroenterology. Liver. Pancreas. Abdomen Hepatic encephalopathy Hepatic Encephalopathy - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Malformations Medical sciences Motor Activity Portacaval Shunt, Surgical Rats Rats, Inbred Strains |
| title | Brain Amino Acids Measured by Intracerebral Dialysis in Portacaval Shunted Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T05%3A32%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20Amino%20Acids%20Measured%20by%20Intracerebral%20Dialysis%20in%20Portacaval%20Shunted%20Rats&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Tossman,%20Ulf&rft.date=1983-04&rft.volume=41&rft.issue=4&rft.spage=1046&rft.epage=1051&rft.pages=1046-1051&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1111/j.1471-4159.1983.tb09049.x&rft_dat=%3Cproquest_cross%3E13812533%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13812533&rft_id=info:pmid/6619844&rfr_iscdi=true |